ID A0A2R8ZAX0_PANPA Unreviewed; 435 AA.
AC A0A2R8ZAX0;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=IF rod domain-containing protein {ECO:0000259|PROSITE:PS51842};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000002184.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000002184.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000002184.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; AJFE02109902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02109903; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R8ZAX0; -.
DR Ensembl; ENSPPAT00000010767.1; ENSPPAP00000002184.1; ENSPPAG00000007869.1.
DR GeneTree; ENSGT00940000161838; -.
DR Proteomes; UP000240080; Chromosome 12.
DR Bgee; ENSPPAG00000007869; Expressed in placenta.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF52; KERATIN, TYPE II CUTICULAR HB6; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT DOMAIN 106..403
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 173..235
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 308..381
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 435 AA; 48138 MW; C7999B1E04793BA4 CRC64;
MSCLYSRLSA PCGVRAVSCI SACGPRPGRC CITAAPYRGV FCYRGLTGGF GSHSVCGGFR
AGSCGRSFGY RSGGTPCITT VSVNESLLTP LNLEIDPNAQ CVKQEEKEQI KSLNSRFAAF
IDKVRFLEQQ NKLLETKLQF FQNRECCESN LEPLFEADSG RLASELNHVQ EVLEGYKKKY
EEEVALRATA ENEFVALKKD VDCAYLRKSD LEANVEALTQ EIDFLRRLYE EEIRVLQSHI
SDTSVVVKMD NSRDLNMHCV VTKIKAQYDD IATRSRAEAE SWYRSKCEEM KATVIRHGET
LCRTKEEINE VNRMIQRLTA EVENAKCQNS KLEAAVAQSE QQGEAALSDA CCKLAELEGT
LQKAKQDMAC LIREYQKVMN SKLGLDIEIA TYRRLLEGEE QSSSCGGVLC GDLCVSGSRP
VTGSVCSAPC SGNVA
//
