ID A0A2R8ZEZ9_PANPA Unreviewed; 458 AA.
AC A0A2R8ZEZ9;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=GDNF family receptor alpha-2 {ECO:0000256|ARBA:ARBA00016726, ECO:0000256|PIRNR:PIRNR038071};
DE Short=GDNF receptor alpha-2 {ECO:0000256|PIRNR:PIRNR038071};
GN Name=GFRA2 {ECO:0000313|Ensembl:ENSPPAP00000001196.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000001196.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000001196.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000001196.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for neurturin. Mediates the NRTN-induced
CC autophosphorylation and activation of the RET receptor. Also able to
CC mediate GDNF signaling through the RET tyrosine kinase receptor.
CC {ECO:0000256|ARBA:ARBA00025392, ECO:0000256|PIRNR:PIRNR038071}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609};
CC Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Membrane
CC {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00004589}.
CC -!- SIMILARITY: Belongs to the GDNFR family.
CC {ECO:0000256|ARBA:ARBA00005961, ECO:0000256|PIRNR:PIRNR038071}.
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DR EMBL; AJFE02083220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02083221; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02083222; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02083223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02083224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02083225; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R8ZEZ9; -.
DR Ensembl; ENSPPAT00000005700.1; ENSPPAP00000001196.1; ENSPPAG00000004816.1.
DR GeneTree; ENSGT00940000156168; -.
DR Proteomes; UP000240080; Chromosome 8.
DR Bgee; ENSPPAG00000004816; Expressed in prefrontal cortex and 5 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098552; C:side of membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.220.110; GDNF binding domain; 1.
DR InterPro; IPR016017; GDNF/GAS1.
DR InterPro; IPR037193; GDNF_alpha.
DR InterPro; IPR003438; GDNF_rcpt.
DR InterPro; IPR003504; GDNF_rcpt_a2.
DR InterPro; IPR017372; Glial_neurotroph_fac_rcpt_a1/2.
DR PANTHER; PTHR10269:SF4; GDNF FAMILY RECEPTOR ALPHA-2; 1.
DR PANTHER; PTHR10269; GDNF RECEPTOR ALPHA; 1.
DR Pfam; PF02351; GDNF; 3.
DR PIRSF; PIRSF038071; GDNF_family_receptor_alpha; 1.
DR PRINTS; PR01318; GDNFRALPHA2.
DR PRINTS; PR01316; GDNFRECEPTOR.
DR SMART; SM00907; GDNF; 3.
DR SUPFAM; SSF110035; GDNF receptor-like; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|PIRNR:PIRNR038071};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor {ECO:0000256|ARBA:ARBA00022622};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR038071};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR038071};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 34..111
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT DOMAIN 155..235
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT DOMAIN 245..341
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT REGION 357..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 458 AA; 50669 MW; 0A738764F8C28D40 CRC64;
PRLANAAHET LRSLASPSSL QGPELHGWRP PVDCVRANEL CAAESNCSSR YRTLRQCLAG
RDRNTMLANK ECQAALEVLQ ESPLYDCRCK RGMKKELQCL QIYWSIHLGL TEGEEFYEAS
PYEPVTSRLS DIFRLASIFS GTGADPVVSA KSNHCLDAAK ACNLNDNCKK LRSSYISICN
REISPTERCN RRKCHKALRQ FFDRVPSEYT YRMLFCSCQD QACAERRRQT ILPSCSYEDK
EKPNCLDLRG VCRTDHLCRS RLADFHANCR ASYQTVTSCP ADNYQACLGS YAGMIGFDMT
PNYVDSSPAG IVVSPWCSCR GSGNMEEECE KFLRDFTENP CLRNAIQAFG NGTDVNVSPK
GPSFQATQAP RVEKTPSLPD DLSDSTSLGT SVITTCTSVQ EQGLKANNSK ELSMCFTELT
TNIIPGSNKV IKPNSGPSRA RPSAALTVLS VLMLKLAL
//
