ID A0A2R8ZFA1_PANPA Unreviewed; 948 AA.
AC A0A2R8ZFA1;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Protein tyrosine phosphatase receptor type N2 {ECO:0000313|Ensembl:ENSPPAP00000001296.1};
GN Name=PTPRN2 {ECO:0000313|Ensembl:ENSPPAP00000001296.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000001296.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000001296.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000001296.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004212}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004212}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 8 subfamily. {ECO:0000256|ARBA:ARBA00025723}.
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DR EMBL; AJFE02055433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02055434; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02055435; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02055436; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02055437; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02055438; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02055439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02055440; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02055441; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02055442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R8ZFA1; -.
DR Ensembl; ENSPPAT00000006121.1; ENSPPAP00000001296.1; ENSPPAG00000004528.1.
DR GeneTree; ENSGT00940000154095; -.
DR Proteomes; UP000240080; Chromosome 7.
DR Bgee; ENSPPAG00000004528; Expressed in prefrontal cortex and 4 other cell types or tissues.
DR GO; GO:0030141; C:secretory granule; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14610; R-PTP-N2; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.30.70.2470; Protein-tyrosine phosphatase receptor IA-2 ectodomain; 1.
DR InterPro; IPR033522; IA-2/IA-2_beta.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR021613; Receptor_IA-2_dom.
DR InterPro; IPR038112; Receptor_IA-2_ectodomain_sf.
DR InterPro; IPR029403; RESP18_dom.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46106; IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C; 1.
DR PANTHER; PTHR46106:SF5; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE N2; 1.
DR Pfam; PF11548; Receptor_IA-2; 1.
DR Pfam; PF14948; RESP18; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SMART; SM01305; RESP18; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 678..938
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 857..929
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 82..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 383..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 608..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..254
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 948 AA; 104144 MW; 48116311BE1DADA5 CRC64;
CLLEEGLCGA SEACVNDGVF GRCQKVPAMD FYRYEVSPVA LQRLRVALQK LSGTGFTWQD
DYTQYVMDQE LADLPKTYLR RPEASSPARL SKHSVGSERR YSREGGAALA KALRRHLPFL
EALSQAPASD VLARTHTAQD RPPAEGDDRF SESILTYVAH TSALTYPPGP RTQLREDLLP
RTLGQLQPDE LSPKVDSGVD RHHLMAALGA YAAQRPPAPP GEGSLEPQYL LRAPSRMPRP
LLAPAAPQKW PSPLGDPEDP SSTGDGARIH TLLKDLQRQP AEVRGLSDLE LDGMAELMAG
LMQGVDHGVA RGSPGRAALG ESGEQADGPK ATLRGDSFPD DGVQDDDDRL YQEVHRLSAT
LGGLLQDHGS RLLPGALPFA KPLDMERKKS EHPEASLSSE EETAGVENVK SQTYSKDLLG
QQPHSEPGAV AFGELQNQMP GPSKEEQSLP AGAQEALGDG LQLEVKPSEE EARGYIVTDR
EVLGPAVTFK VSANVQNVTT EDVEKATVDN KDKLEETSGL KILQTGVGSK SKLKFLPPQA
EQEDSTKFIA LTLVSLACIL GVLLASGLIY CLRHSSQHRL KEKLSGLGGD PGADATAAYQ
ELCRQRMATR PPDRPEGPHT SRISSVSSQF SDGPIPSPSA RSSASSWSEE PVQSNMDIST
GHMILSYMED HLKNKNRLEK EWEALCAYQA EPNSSFVAQR EENVPKNRSL AVLTYDHSRV
LLKAENSHSH SDYINASPIM DHDPRNPTYI ATQGPLPATV ADFWQMVWES GCVVIVMLTP
LAENGVRQCY HYWPDEGSNL YHIYEVNLVS EHIWCEDFLV RSFYLKNLQT NETRTVTQFH
FLSWYDRGVP SSSRSLLDFR RKVNKCYRGR SCPIIVHCSD GAGRSGTYVL IDMVLNKMAK
GAKEIDIAAT LEHLRDQRPG MVQTKEQFEF ALTAVAEEVN AILKALPQ
//
