ID A0A2R8ZGA8_PANPA Unreviewed; 693 AA.
AC A0A2R8ZGA8;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=NLR family pyrin domain containing 11 {ECO:0000313|Ensembl:ENSPPAP00000004044.1};
GN Name=NLRP11 {ECO:0000313|Ensembl:ENSPPAP00000004044.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000004044.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000004044.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000004044.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJFE02030585; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030586; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R8ZGA8; -.
DR Ensembl; ENSPPAT00000018795.1; ENSPPAP00000004044.1; ENSPPAG00000017134.1.
DR GeneTree; ENSGT00940000163635; -.
DR Proteomes; UP000240080; Chromosome 19.
DR GO; GO:0016715; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR020611; Cu2_ascorb_mOase_CS-1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690:SF5; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 11; 1.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS00084; CU2_MONOOXYGENASE_1; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT DOMAIN 48..180
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 645..666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 693 AA; 79850 MW; 78285ABFC47B8B10 CRC64;
MRRKFMLQWE SHTFGKFHYK FFRDVSSDVF YILQLAYDST SYYSANNLNV FLMGERASGK
TMVINLAVLR WIKGEMWQNM ISYVVHLTSH EINQMTNSSL AELIAKDWPD GQAPIADILS
DPKKLLFILE DLDNIRFELN VNESALCSNS TQKVPIPVLL VSLLKRKMAP GCWFLISSRP
TRGNNVKSFL KEVDCCTTLQ LSKEKREIYF NSFFKDRQRA SAALQLVHED EILVGLCRVA
ILCWITCTVL KRQMDKGRDF QLCCQTPTDL HAHFLADALT SEAGLTANQY HLGLLKRLCL
LAAGGLFLST LNFSGEDLRC VGFTEADVSV LQAANILLPS STHKDRYKFI HLNVQEFCTA
IAFLMAVPNY LIPSGSREYK EKREQYSDFN QVFTFIFGLL NANRRKILET SFGYQLPMVD
SFKWYSVGYM KYLDRDPEKL THHMPLFYCL YENREEEFVK TIVDALMEVT VYLRSDKDMM
VSLYCLDYCC HLRTLKLSVQ HIFQNKEPLI RPTASQMKSL VYWREICSLF YTMESLWELH
IFDNDLNGIS ERILSKALEH SSCKLRTLKL SYVSTASGFE DLLKALARNR SLTYLSINCT
SISLNMFSLL HDILHEPTCQ ISHLRIHRPT RWLTPGIPTL WEAKAGRSPE VRRSRQPDQH
GETSSLLKMQ NYPSMVARAC NPSYSGGSGR RIT
//
