ID A0A2R8ZGM4_PANPA Unreviewed; 1408 AA.
AC A0A2R8ZGM4;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Dispatched RND transporter family member 1 {ECO:0000313|Ensembl:ENSPPAP00000004140.1};
GN Name=DISP1 {ECO:0000313|Ensembl:ENSPPAP00000004140.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000004140.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000004140.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000004140.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the dispatched family.
CC {ECO:0000256|ARBA:ARBA00038046}.
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DR EMBL; AJFE02049019; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02049020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPPAT00000019278.1; ENSPPAP00000004140.1; ENSPPAG00000017626.1.
DR GeneTree; ENSGT00940000157407; -.
DR OMA; NGLLAMC; -.
DR Proteomes; UP000240080; Chromosome 1.
DR Bgee; ENSPPAG00000017626; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR45951:SF4; PROTEIN DISPATCHED HOMOLOG 1; 1.
DR PANTHER; PTHR45951; PROTEIN DISPATCHED-RELATED; 1.
DR Pfam; PF02460; Patched; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 72..94
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 408..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 481..505
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 517..538
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 603..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 869..888
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 894..916
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 923..943
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 963..980
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 992..1011
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 408..542
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 1302..1321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1408 AA; 158824 MW; 119D7727D2A60538 CRC64;
MQPHSEYSAS LCPNHSPVYQ TTCCLQPSPS FCLHHPWPDH FQHQPVQQHI ANIRPSRPFK
LPKSYAALIA DWPVVVLGMC TMFIVVCALV GVLVPELPDF SDPLLGFEPR GTAIGQRLVT
WNNMVKNTGY KATLANYPFK YADEQAKSHR DDRWSDDHYE REKREVDWNF HKDSFFCDVP
SDRYSRVVFT SSGGETLWNL PAIKSMCNVD NSRIRSHPQF GDLCQRTTAA SCCPSWTLGN
YIAILNNRSS CQKIVERDVS HTLKLLRTCA KHYQNGTLGP DCWDMAARRK DQLKCTNVPR
KCTKYNAVYQ ILHYLVDKDF MTPKTADYAT PALKYSMLFS PTEKGESMMN IYLDNFENWN
SSDGVTTITG IEFGIKHSLF QDYLLMDTVY PAIAIVIVLL VMCVYTKSMF ITLMTMFAII
SSLIVSYFLY RVVFHFEFFP FMNLTALIIL VGIGADDAFV LCDVWNYTKF DKPHAETSET
VSITLQHAAL SMFVTSFTTA AAFYANYVSN ITAIRCFGVY AGTAILVNYV LMVTWLPAVV
VLHERYLLNI FTCFKKPQQQ IYDNKSCWTV ACQKCHKVLF AISEASRIFF EKVLPCIVIK
FRYLWLFWFL ALTVGGAYIV CINPKMKLPS LELSEFQVFR SSHPFERYDA EYKKLFMFER
VHHGEELHMP ITVIWGVSPE DNGNPLNPKS KGKLTLDSSF NIASPASQAW ILHFCQKLRN
QTFFYQTDEQ DFTSCFIETF KQWMENQDCD EPALYPCCSH WSFPYKQEIF ELCIKRAIME
LERSTGYHLD SKTPGPRFDI NDTIRAVVLE FQSTYLFTLA YEKMHQFYKE VDSWISSELS
SAPEGLSNGW FVSNLEFYDL QDSLSDGTLI AMGLSVAVAF SVMLLTTWNI IISLYAIISI
AGTIFVTVGS LVLLGWELNV LESVTISVAV GLSVDFAVHY GVAYRLAPDP DREGKVIFSL
SRMGSAIAMA ALTTFVAGAM MMPSTVLAYT QLGTFMMLIM CISWAFATFF FQCMCRCLGP
QGTCGQIPLP KKLQCSAFSH ALSTSPSDKG QSKTHTINAY HLDPRGPKSE LEHEFYELEP
LASHSCTSSE KTTYEETHIC SEFFNSQAKN LGMPVHAAYN SELSKSTKND TGSALLQPPL
EQHTVCHFFS LNQRCSCPNA YKHLKYGPHS CQQMGDCLCH QCAPTTSSFV QIQNGVAPLK
ATHQAAEGFV HPITHIHHCP CLQGRVKPAG MQNSLPRNFF LHPVQHIQAQ EKIGKTNVHS
LQRSIEEHLP KMAEPSSFVC RSTGSLLKTC CDPENKQREL CKNRDMSNLE SSGGTENKAG
GKVELSLSQT DASVNSEHFN QNEPKVLFNH LMGEAGCRSC PNNSQSCGRI VRVKCNSVDC
QMPNMEANVP AVLTHSELSG ESLLIKTL
//
