UniProt: A0A2R8ZGR9

Database: UniProt
Entry: A0A2R8ZGR9_PANPA

LinkDB:  A0A2R8ZGR9_PANPA 
Original site:  A0A2R8ZGR9_PANPA

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Ontology (4)   
   GO (4)   
Chemical reaction (2)   
   KEGG ENZYME (2)   
Gene (5)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (5)   
   EMBL (5)   
Protein domain (10)   
   InterPro (7)   
   Pfam (2)   
   SMART (1)   
Literature (1)   
   PubMed (1)   
All databases (29)   

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ID   A0A2R8ZGR9_PANPA        Unreviewed;       329 AA.
AC   A0A2R8ZGR9;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=Prostaglandin reductase 1 {ECO:0000256|ARBA:ARBA00020651};
DE            EC=1.3.1.48 {ECO:0000256|ARBA:ARBA00011981};
DE            EC=1.3.1.74 {ECO:0000256|ARBA:ARBA00012410};
DE   AltName: Full=15-oxoprostaglandin 13-reductase {ECO:0000256|ARBA:ARBA00033119};
DE   AltName: Full=Dithiolethione-inducible gene 1 protein {ECO:0000256|ARBA:ARBA00032255};
DE   AltName: Full=Leukotriene B4 12-hydroxydehydrogenase {ECO:0000256|ARBA:ARBA00031851};
DE   AltName: Full=NAD(P)H-dependent alkenal/one oxidoreductase {ECO:0000256|ARBA:ARBA00032297};
GN   Name=PTGR1 {ECO:0000313|Ensembl:ENSPPAP00000001844.1};
OS   Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000001844.1, ECO:0000313|Proteomes:UP000240080};
RN   [1] {ECO:0000313|Ensembl:ENSPPAP00000001844.1, ECO:0000313|Proteomes:UP000240080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22722832; DOI=10.1038/nature11128;
RA   Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA   Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA   Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA   Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA   Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA   Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA   Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA   Paabo S.;
RT   "The bonobo genome compared with the chimpanzee and human genomes.";
RL   Nature 486:527-531(2012).
RN   [2] {ECO:0000313|Ensembl:ENSPPAP00000001844.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate +
CC         NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate +
CC         H(+) + NADPH; Xref=Rhea:RHEA:51212, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133974,
CC         ChEBI:CHEBI:133975; Evidence={ECO:0000256|ARBA:ARBA00023498};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51213;
CC         Evidence={ECO:0000256|ARBA:ARBA00023498};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin
CC         F2alpha + H(+) + NADPH; Xref=Rhea:RHEA:50588, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133374,
CC         ChEBI:CHEBI:133409; Evidence={ECO:0000256|ARBA:ARBA00023548};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50590;
CC         Evidence={ECO:0000256|ARBA:ARBA00023548};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-
CC         oxoprostaglandin E1 + H(+) + NADPH; Xref=Rhea:RHEA:50584,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57401, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:133408;
CC         Evidence={ECO:0000256|ARBA:ARBA00023544};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50586;
CC         Evidence={ECO:0000256|ARBA:ARBA00023544};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-
CC         oxoprostaglandin F1alpha + H(+) + NADPH; Xref=Rhea:RHEA:50592,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:79072, ChEBI:CHEBI:133411;
CC         Evidence={ECO:0000256|ARBA:ARBA00023543};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50594;
CC         Evidence={ECO:0000256|ARBA:ARBA00023543};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=20-hydroxy-leukotriene B4 + NADP(+) = 12-oxo-20-hydroxy-
CC         leukotriene B4 + H(+) + NADPH; Xref=Rhea:RHEA:51208,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57460, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:133346;
CC         Evidence={ECO:0000256|ARBA:ARBA00023517};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51209;
CC         Evidence={ECO:0000256|ARBA:ARBA00023517};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-hydroxynonanal + NADP(+) = (E)-4-hydroxynon-2-enal + H(+) +
CC         NADPH; Xref=Rhea:RHEA:64736, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:58968, ChEBI:CHEBI:156112;
CC         Evidence={ECO:0000256|ARBA:ARBA00023553};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:64738;
CC         Evidence={ECO:0000256|ARBA:ARBA00023553};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=6-trans-leukotriene B4 + NADP(+) = 12-oxo-(5S)-hydroxy-
CC         (6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH;
CC         Xref=Rhea:RHEA:51204, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:90723, ChEBI:CHEBI:133974;
CC         Evidence={ECO:0000256|ARBA:ARBA00023496};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51205;
CC         Evidence={ECO:0000256|ARBA:ARBA00023496};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NADP(+) + nonan-2-one = (3E)-nonen-2-one + H(+) + NADPH;
CC         Xref=Rhea:RHEA:50616, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:77927, ChEBI:CHEBI:133457;
CC         Evidence={ECO:0000256|ARBA:ARBA00023696};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50618;
CC         Evidence={ECO:0000256|ARBA:ARBA00023696};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NADP(+) + octanal = (2E)-octenal + H(+) + NADPH;
CC         Xref=Rhea:RHEA:50780, ChEBI:CHEBI:15378, ChEBI:CHEBI:17935,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:61748;
CC         Evidence={ECO:0000256|ARBA:ARBA00023504};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50782;
CC         Evidence={ECO:0000256|ARBA:ARBA00023504};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NADP(+) + pentan-2-one = (E)-pent-3-en-2-one + H(+) + NADPH;
CC         Xref=Rhea:RHEA:50788, ChEBI:CHEBI:15378, ChEBI:CHEBI:16472,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:145276;
CC         Evidence={ECO:0000256|ARBA:ARBA00024160};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50790;
CC         Evidence={ECO:0000256|ARBA:ARBA00024160};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an n-alkanal + NADP(+) = an alk-2-enal + H(+) + NADPH;
CC         Xref=Rhea:RHEA:13737, ChEBI:CHEBI:12834, ChEBI:CHEBI:13757,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.74;
CC         Evidence={ECO:0000256|ARBA:ARBA00023507};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:13739;
CC         Evidence={ECO:0000256|ARBA:ARBA00023507};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=decanal + NADP(+) = (2E)-decenal + H(+) + NADPH;
CC         Xref=Rhea:RHEA:50612, ChEBI:CHEBI:15378, ChEBI:CHEBI:31457,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133455;
CC         Evidence={ECO:0000256|ARBA:ARBA00023691};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50614;
CC         Evidence={ECO:0000256|ARBA:ARBA00023691};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dodecanal + NADP(+) = (2E)-dodecenal + H(+) + NADPH;
CC         Xref=Rhea:RHEA:50784, ChEBI:CHEBI:15378, ChEBI:CHEBI:27836,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133741;
CC         Evidence={ECO:0000256|ARBA:ARBA00023530};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50786;
CC         Evidence={ECO:0000256|ARBA:ARBA00023530};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hexanal + NADP(+) = (E)-hex-2-enal + H(+) + NADPH;
CC         Xref=Rhea:RHEA:50776, ChEBI:CHEBI:15378, ChEBI:CHEBI:28913,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:88528;
CC         Evidence={ECO:0000256|ARBA:ARBA00034052};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50778;
CC         Evidence={ECO:0000256|ARBA:ARBA00034052};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + H(+) +
CC         NADPH; Xref=Rhea:RHEA:50608, ChEBI:CHEBI:15378, ChEBI:CHEBI:57461,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133309;
CC         Evidence={ECO:0000256|ARBA:ARBA00023545};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50609;
CC         Evidence={ECO:0000256|ARBA:ARBA00023545};
CC   -!- SUBUNIT: Monomer or homodimer. {ECO:0000256|ARBA:ARBA00011852}.
CC   -!- SIMILARITY: Belongs to the NADP-dependent oxidoreductase L4BD family.
CC       {ECO:0000256|ARBA:ARBA00010460}.
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DR   EMBL; AJFE02033672; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJFE02033673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJFE02033674; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJFE02033675; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJFE02033676; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003810914.1; XM_003810866.1.
DR   RefSeq; XP_003810915.1; XM_003810867.2.
DR   AlphaFoldDB; A0A2R8ZGR9; -.
DR   Ensembl; ENSPPAT00000009150.1; ENSPPAP00000001844.1; ENSPPAG00000008355.1.
DR   GeneID; 100979208; -.
DR   KEGG; pps:100979208; -.
DR   CTD; 22949; -.
DR   GeneTree; ENSGT00940000154810; -.
DR   OMA; PIKNIHN; -.
DR   OrthoDB; 179761at2759; -.
DR   Proteomes; UP000240080; Chromosome 9.
DR   Bgee; ENSPPAG00000008355; Expressed in liver and 6 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0036132; F:13-prostaglandin reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0047522; F:15-oxoprostaglandin 13-oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0035798; F:2-alkenal reductase (NADP+) activity; IEA:Ensembl.
DR   CDD; cd08294; leukotriene_B4_DH_like; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR041694; ADH_N_2.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR045010; MDR_fam.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR014190; PTGR1.
DR   NCBIfam; TIGR02825; B4_12hDH; 1.
DR   PANTHER; PTHR43205; PROSTAGLANDIN REDUCTASE; 1.
DR   PANTHER; PTHR43205:SF33; PROSTAGLANDIN REDUCTASE 1; 1.
DR   Pfam; PF16884; ADH_N_2; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022501};
KW   Hydroxylation {ECO:0000256|ARBA:ARBA00023278};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022501};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Prostaglandin metabolism {ECO:0000256|ARBA:ARBA00022501};
KW   Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT   DOMAIN          17..327
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   329 AA;  35874 MW;  9BB5084D903289B9 CRC64;
     MVRTKTWTLK KHFVGYPTNS DFELKTAELP PLKNGEVLLE ALFLTVDPYM RMAAKRLKEG
     DTMMGQQVAK VVESKNAALP KGTIVLASPG WTTHSISDGK DLEKLLTEWP DTIPLSLALG
     TVGMPGLTAY FGLLEICGVK GGETVMVNAA AGAVGSVVGQ IAKLKGCKVV GAVGSDEKVA
     YLQKLGFDVV FNYKTVESLE ETLKKASPDG YDCYFDNVGG EFSNTVIGQM KKFGRIAICG
     AISTYNRTGP LPPGPPPEIV IYQELRMEAF VVYRWQGDAR QKALKDLLKW VLEGKIQYKE
     YIIEGFENMP AAFMGMLKGD NLGKTIVKA
//

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