ID   A0A2R8ZKA0_PANPA        Unreviewed;       695 AA.
AC   A0A2R8ZKA0;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Lebercilin LCA5 {ECO:0000313|Ensembl:ENSPPAP00000005393.1};
GN   Name=LCA5 {ECO:0000313|Ensembl:ENSPPAP00000005393.1};
OS   Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000005393.1, ECO:0000313|Proteomes:UP000240080};
RN   [1] {ECO:0000313|Ensembl:ENSPPAP00000005393.1, ECO:0000313|Proteomes:UP000240080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22722832; DOI=10.1038/nature11128;
RA   Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA   Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA   Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA   Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA   Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA   Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA   Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA   Paabo S.;
RT   "The bonobo genome compared with the chimpanzee and human genomes.";
RL   Nature 486:527-531(2012).
RN   [2] {ECO:0000313|Ensembl:ENSPPAP00000005393.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the LCA5 family.
CC       {ECO:0000256|ARBA:ARBA00010229}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJFE02015609; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003805870.1; XM_003805822.2.
DR   AlphaFoldDB; A0A2R8ZKA0; -.
DR   STRING; 9597.ENSPPAP00000005393; -.
DR   Ensembl; ENSPPAT00000024463.1; ENSPPAP00000005393.1; ENSPPAG00000022297.1.
DR   GeneID; 100987701; -.
DR   KEGG; pps:100987701; -.
DR   CTD; 167691; -.
DR   GeneTree; ENSGT00560000077266; -.
DR   OMA; SGKSNPF; -.
DR   OrthoDB; 2971757at2759; -.
DR   Proteomes; UP000240080; Chromosome 6.
DR   Bgee; ENSPPAG00000022297; Expressed in cerebellum and 6 other cell types or tissues.
DR   GO; GO:0032391; C:photoreceptor connecting cilium; IEA:Ensembl.
DR   GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR   InterPro; IPR026188; Lebercilin-like.
DR   InterPro; IPR028933; Lebercilin_dom.
DR   PANTHER; PTHR16650; C21ORF13-RELATED; 1.
DR   PANTHER; PTHR16650:SF10; LEBERCILIN; 1.
DR   Pfam; PF15619; Lebercilin; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT   DOMAIN          100..292
FT                   /note="Lebercilin"
FT                   /evidence="ECO:0000259|Pfam:PF15619"
FT   REGION          1..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          520..546
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          560..580
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          604..683
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          105..291
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          396..423
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        8..22
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..49
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        522..546
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        606..626
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        643..683
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   695 AA;  80397 MW;  36BDAF6CD5B594AD CRC64;
     MGERAGSPGT DQERKAGKHH YSYSSDFETP QSSGRSSLVS SSPASVRRKN PKRQTSDGQV
     HHQAPRKPSP KGLPNRKGVR VGFRSQSLNR EPLRKDTDLV TKRILSARLL KINELQNEVS
     ELQVKLAELL KENKSLKRLQ YRQEKALNKF EDAENEISQL IFRHNNEITA LKERLRKSQE
     KERATEKRVK DTESELFRTK FSLQKLKEIS EARHLPERDD LAKKLVSAEL KLDDTERRIK
     ELSKNLELST NSFQRQLLAE RKRAYEAHDE NKVLQKEVQR LYHKLKEKER ELDIKNIYSN
     RLPKSSPNKE LALRKNAACQ SDFADLCTKG VQTMEDFKPE EYPLTPETIM CYENKWEEPG
     HLTLDLQSQK QDRHGEAGIL NPIMEREEKF VKDEELHVVK QEVEKLEDEW EREELDKKQK
     EKASLLEREE KPEWETGRYQ LGMYPIQNMD KLQGEEEERL KREMLLAKLN EIDRELQDSR
     NLKYPVLPLL PDFESKRHSP ERSPKTYRFS ESSERLFNGH HLQDISFSTP KGEGQNSGNV
     RSPASPNEFA FGSYVPSFAK TSERSNPFSQ KSSFLDFQRN SMEKLSKDGV DLITRKEKKA
     NLMEQLFGAS GSSTISSKSS DPNSVASGKG DIDPLNFLPG NKGSRDQEHD EDEDFFLSEG
     RSFNPNRHRL KHADDKPAVK AVDSVEDEIE EVALR
//