ID A0A2R8ZKP4_PANPA Unreviewed; 171 AA.
AC A0A2R8ZKP4;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Granulocyte colony-stimulating factor {ECO:0000256|ARBA:ARBA00019452};
GN Name=CSF3 {ECO:0000313|Ensembl:ENSPPAP00000005199.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000005199.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000005199.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000005199.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Granulocyte/macrophage colony-stimulating factors are
CC cytokines that act in hematopoiesis by controlling the production,
CC differentiation, and function of 2 related white cell populations of
CC the blood, the granulocytes and the monocytes-macrophages. This CSF
CC induces granulocytes. {ECO:0000256|ARBA:ARBA00024794}.
CC -!- SIMILARITY: Belongs to the IL-6 superfamily.
CC {ECO:0000256|ARBA:ARBA00007432}.
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DR EMBL; AJFE02111225; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R8ZKP4; -.
DR Ensembl; ENSPPAT00000023698.1; ENSPPAP00000005199.1; ENSPPAG00000021596.1.
DR GeneTree; ENSGT00390000017328; -.
DR Proteomes; UP000240080; Chromosome 17.
DR Bgee; ENSPPAG00000021596; Expressed in placenta and 2 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0045639; P:positive regulation of myeloid cell differentiation; IEA:InterPro.
DR Gene3D; 1.20.1250.10; -; 2.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR040117; GCSF/MGF.
DR InterPro; IPR030474; IL-6/GCSF/MGF.
DR PANTHER; PTHR10511; GRANULOCYTE COLONY-STIMULATING FACTOR; 1.
DR PANTHER; PTHR10511:SF2; GRANULOCYTE COLONY-STIMULATING FACTOR; 1.
DR Pfam; PF16647; GCSF; 1.
DR PRINTS; PR00433; IL6GCSFMGF.
DR SMART; SM00126; IL6; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..171
FT /note="Granulocyte colony-stimulating factor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015356722"
SQ SEQUENCE 171 AA; 18404 MW; 6D9B277632A1D1A2 CRC64;
MAGPAAQSPM KLMALQLLLW HSALWTVQEA TPLGPASSLP QSFLLKCLEQ VRKIQGDGAA
LQEKLVSEAG CLSQLHSGLF LYQGLLQALE GISPELGPTL DTLQLDVADF ATTIWQQMEE
LGMAPALQPT QGAMPAFASA FQRRAGGVLV ASHLQSFLEV SYRVLRHLAQ P
//
