ID A0A2R8ZMY4_PANPA Unreviewed; 481 AA.
AC A0A2R8ZMY4;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=L3MBTL histone methyl-lysine binding protein 4 {ECO:0008006|Google:ProtNLM};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000004143.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000004143.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000004143.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AJFE02061195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02061196; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R8ZMY4; -.
DR STRING; 9597.ENSPPAP00000004143; -.
DR Ensembl; ENSPPAT00000019285.1; ENSPPAP00000004143.1; ENSPPAG00000017617.1.
DR GeneTree; ENSGT00940000158264; -.
DR OMA; MNYLKAC; -.
DR Proteomes; UP000240080; Chromosome 18.
DR Bgee; ENSPPAG00000017617; Expressed in testis and 5 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd20136; MBT_L3MBTL4_rpt2; 1.
DR Gene3D; 2.30.30.140; -; 3.
DR Gene3D; 4.10.320.30; -; 1.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR002515; Znf_C2H2C.
DR InterPro; IPR036060; Znf_C2H2C_sf.
DR PANTHER; PTHR12247:SF78; LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE PROTEIN 4; 1.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR Pfam; PF02820; MBT; 3.
DR Pfam; PF01530; zf-C2HC; 1.
DR SMART; SM00561; MBT; 3.
DR SUPFAM; SSF103637; CCHHC domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 3.
DR PROSITE; PS51079; MBT; 3.
DR PROSITE; PS51802; ZF_CCHHC; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01143}.
FT REPEAT 52..152
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 160..260
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 269..364
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 481 AA; 55209 MW; 7B31804A7427C3C8 CRC64;
MKQPNRKRKL NMDSKERLDQ DGRLEQAEEE KKPKDSTTPL SHVPSAAAQG AWSWEWYLKE
QKAVAAPVEL FSKDQSFPEH ENGFQIGMRL EGIDPRHPSV FCVLSVAEVC GYRLRLHFDG
YLSCYDFWTN AGSPDIHPVG WCEKTKHELH IPKGYRKDKF VWMDYLKACK LQNAPKKLFR
NRSPNGPMSK EFQVGMKLEA VDRKNPSLVC VATIADIVED RLLVHFDNWD DSYDYWCDVN
SPYVQPVGWC QENGRTLIAP QGYPNPENFS WTEYLEATQT NAVPAKVFKM RLPHGFLPNM
KLEVVDKRNP RLIRVATIVD VDDQRVKVHF DGWDHKYDYW VEADSPDIHP IGWCDVTGHP
LEVPQRTNDL KILPGQAVCP TPGCRGIGHI RGPRYSGHHS AFGCPYSDMN LKKEATLHDR
LREQTQANLE SDSSHSKSKS LCSLNFNGKH EKVNSQPRLV QQAKCLKIKG KEDIDLDNLF
R
//
