ID A0A2R8ZR08_PANPA Unreviewed; 2022 AA.
AC A0A2R8ZR08;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Calcium voltage-gated channel subunit alpha1 I {ECO:0000313|Ensembl:ENSPPAP00000006967.1};
GN Name=CACNA1I {ECO:0000313|Ensembl:ENSPPAP00000006967.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000006967.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000006967.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000006967.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AJFE02074401; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02074402; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02074403; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02074404; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02074405; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02074406; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02074407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02074408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02074409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPPAT00000028873.1; ENSPPAP00000006967.1; ENSPPAG00000025913.1.
DR GeneTree; ENSGT00940000158594; -.
DR OMA; MMGNIGA; -.
DR Proteomes; UP000240080; Chromosome 22.
DR Bgee; ENSPPAG00000025913; Expressed in cerebellum and 2 other cell types or tissues.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR005445; VDCC_T_a1.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF209; VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR01629; TVDCCALPHA1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 118..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..229
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 724..746
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 802..824
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1133..1151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1163..1179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1199..1227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1262..1281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1361..1384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1440..1457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1477..1496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1561..1588
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1663..1684
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 83..405
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 602..830
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1131..1394
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1440..1694
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 834..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 983..1002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1709..1740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1822..1852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1891..1915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1922..1941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1986..2022
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1393..1420
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 529..543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..565
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1836..1852
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1996..2010
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2022 AA; 225014 MW; 6BC8FED8B3399B31 CRC64;
MAESASLPSS SAAAPAAEPG VTTEQPGPRS PLSSPPGLEE PLDGADPHVP HPDLAPVAFF
CLRQTTSPRN WCIKMVCNPY PPMLVILLNC VTLGMYQPCD DMDCLSDRCK ILQVFDDFIF
IFFAMEMVLK MVALGIFGKK CYLGDTWNRL DFFIVMAGMV EYSLDLQNIN LSAIRTVRVL
RPLKAINRVP SMRILVNLLL DTLPMLGNVL LLCFFVFFIF GIIGVQLWAG LLRNRCFLEE
NFTIQGDVAL PPYYQPEEDD EMPFICSLSG DNGIMGCHEI PPLKEQGREC CLSKDDVYDF
GAGRQDLNAS GLCVNWNRYY NVCRTGSANP HKGAINFDNI GYAWIVIFQV ITLEGWVEIM
YYVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE TKQREHRLML EQRQRYLSSS
TVASYAEPGD CYEEIFQYVC HILRKAKRRA LGLYQALQSR RQALGPEAPA PAKPGPHAKE
PRHYQLCPQH SPLDATPHTL VQPIPATLAS DPASCPCCQH EAGRRPSGLG STDSGQEGSG
SGSSAGGEDE ADGDGARSSE DGASSELGKE EEEEEQADGA VWLCGDVWRE TRAKLRGIVD
SKYFNRGIMM AILVNTVSMG IEHHEQPEEL TNILEICNVV FTSMFALEMI LKLAAFGLFD
YLRNPYNIFD SIIVIISIWE IVGQADGGLS VLRTFRLLRV LKLVRFMPAL RRQLVVLMKT
MDNVATFCML LMLFIFIFSI LGMHIFGCKF SLRTDTGDTV PDRKNFDSLL WAIVTVFQIL
TQEDWNVVLY NGMASTSPWA SLYFVALMTF GNYVLFNLLV AILVEGFQAE GDANRSYSDE
DQSSSNIEEF DKLQEGLDSS GDPKLCPIPM TPNGHLDPSL PLVGHLGPAG AAGPPPRLSL
QPDPMLVALG SRKSSVMSLG RMSYDQRSLS SSRSSYYGPW GRSAAWASRR SSWNSLKHKP
PSAEHESLLS AERGGGARVC EVATDEGPPR AAPLHAPHAH HVHHGPHLAH RHRHHRRTLS
LDNRDSVDLA ELVPAVGAHP RAAWRAAGPA PGHEDCNGRM PSIAKDVFTK MGDRGDRGED
EEEIDYTLCF RVRKMIDVYK PDWCEVREDW SVYLFSPENR FRVLCQTIIA HKLFDYVVLA
FIFLNCITIA LERPQIEAGS TERIFLTVSN YIFTAIFVGE MTLKVQAYLR SSWNVLDGFL
VFVSIIDIVV SLASAGGAKI LGVLRVLRLL RTLRPLRVIS RAPGLKLVVE TLISSLKPIG
NIVLICCAFF IIFGILGVQL FKGKFYHCLG VDTRNITNRS DCMAANYRWV HHKYNFDNLG
QALMSLFVLA SKDGWVNIMY NGLDAVAVDQ QPVTNHNPWM LLYFISFLLI VSFFVLNMFV
GVVVENFHKC RQHQEAEEAR RREEKRLRRL EKKRRKAQRL PYYATYCHTR LLIHSMCTSH
YLDIFITFII CLNVVTMSLE HYNQPTSLET ALKYCNYMFT TVFVLEAVLK LVAFGLRRFF
KDRRWNQLDL AIVLLSVMGI TLEEIEINAA LPINPTIIRI MRVLRIARVL KLLKMATGMR
ALLDTVVQAL PQVGNLGLLF MLLFFIYAAL GVELFGKLVC NDENPCEGMS RHATFENFGM
AFLTLFQVST GDNWNGIMKD TLRDCTHDER SCLSSLQFVS PLYFVSFVLT AQFVLINVVV
AVLMKHLDDS NKEAQEDAEM DAELELEMAH GLGPGPRLPT GSPGRPPGRG PGGAGGGGDT
EGGLCRRCYS PAQENLWLDS VSLIIKDSLE GELTIIDNLS GSIFHHYSSP AGCKKCHHDK
QEVQLAETEA FSLNSDRSSS ILLGDDLSLE DPTACPPGRK DSKGELDPPE PMRVGDLGEC
FFPLSSTAVS PDPENFLCEM EEIPFNPVRS WLKHDSSQAP PSPFSPDASS PLLPMPAEFF
HPAVSASQKG PEKGTGTGTL PKIALQGSWA SLRSPRVNCT LLRQVPTPPR PQSTGLWARA
TAPXXXXXXX APLPMGLGPL APPPQPLPGE LEPGDAASKR KR
//
