ID A0A2R8ZR78_PANPA Unreviewed; 432 AA.
AC A0A2R8ZR78;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=ETS variant transcription factor 4 {ECO:0000313|Ensembl:ENSPPAP00000006411.1};
GN Name=ETV4 {ECO:0000313|Ensembl:ENSPPAP00000006411.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000006411.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000006411.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000006411.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJFE02016576; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02016577; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R8ZR78; -.
DR STRING; 9597.ENSPPAP00000006411; -.
DR Ensembl; ENSPPAT00000027643.1; ENSPPAP00000006411.1; ENSPPAG00000024983.1.
DR GeneTree; ENSGT00940000158142; -.
DR OMA; DPCVPYL; -.
DR Proteomes; UP000240080; Chromosome 17.
DR Bgee; ENSPPAG00000024983; Expressed in placenta and 4 other cell types or tissues.
DR GO; GO:0005694; C:chromosome; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0045618; P:positive regulation of keratinocyte differentiation; IEA:Ensembl.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR006715; ETS_PEA3_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF181; ETS TRANSLOCATION VARIANT 4; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF04621; ETS_PEA3_N; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT DOMAIN 289..369
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 36..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 432 AA; 48295 MW; EAE60D567A3BD5A8 CRC64;
LFQDLSHFQE TWLAEAQVPD SDEQFVPDFH SENLAFHSPT TRIKKEPQSP RTDPALSCSR
KPPLPYHHGE QCLYSSAYDP PRQIAIKSPA PGALGQSPLQ PFPRAEQRNF LRSSGTSQPH
PGHGYLGEHS SVFQQPLDIC HSFTSQGGGR EPLPAPYQHQ LSEPCPPYPQ QSFKQEYHDP
LYEQAGQPAV DQGGVNGHRY PGAGVVIKQE QTDFAYDSDV TGCASMYLHT EGFSGPSPGD
GAMGYGYEKS LRPFPDDVCV VPEKFEGDIK QEGVGAFREG PPYQRRGALQ LWQFLVALLD
DPTNAHFIAW TGRGMEFKLI EPEEVARLWG IQKNRPAMNY DKLSRSLRYY YEKGIMQKVA
GERYVYKFVC EPEALFSLAF PDNQRPALKA EFDRPVSEED TVPLSHLDES PAYLPELAGP
AQPFGPKGGY SY
//
