ID A0A2R8ZWN6_PANPA Unreviewed; 687 AA.
AC A0A2R8ZWN6;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Adhesion G-protein coupled receptor G1 {ECO:0000256|ARBA:ARBA00019701};
DE AltName: Full=G-protein coupled receptor 56 {ECO:0000256|ARBA:ARBA00033134};
GN Name=ADGRG1 {ECO:0000313|Ensembl:ENSPPAP00000009381.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000009381.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000009381.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000009381.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC raft {ECO:0000256|ARBA:ARBA00004285}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7
CC subfamily. {ECO:0000256|ARBA:ARBA00010933}.
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DR EMBL; AJFE02083812; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02083813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02083814; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003823780.1; XM_003823732.2.
DR RefSeq; XP_003823782.1; XM_003823734.2.
DR RefSeq; XP_008975651.1; XM_008977403.1.
DR RefSeq; XP_008975652.1; XM_008977404.1.
DR RefSeq; XP_014197258.1; XM_014341772.1.
DR AlphaFoldDB; A0A2R8ZWN6; -.
DR STRING; 9597.ENSPPAP00000009381; -.
DR Ensembl; ENSPPAT00000032022.1; ENSPPAP00000009381.1; ENSPPAG00000027907.1.
DR GeneID; 100974258; -.
DR CTD; 9289; -.
DR GeneTree; ENSGT00940000160843; -.
DR OMA; NLLWAIF; -.
DR OrthoDB; 5477252at2759; -.
DR Proteomes; UP000240080; Chromosome 16.
DR Bgee; ENSPPAG00000027907; Expressed in adult mammalian kidney and 6 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0097451; C:glial limiting end-foot; IEA:Ensembl.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005518; F:collagen binding; IEA:Ensembl.
DR GO; GO:0050840; F:extracellular matrix binding; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0021796; P:cerebral cortex regionalization; IEA:Ensembl.
DR GO; GO:0061484; P:hematopoietic stem cell homeostasis; IEA:Ensembl.
DR GO; GO:0021819; P:layer formation in cerebral cortex; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:2001223; P:negative regulation of neuron migration; IEA:Ensembl.
DR GO; GO:0061351; P:neural precursor cell proliferation; IEA:Ensembl.
DR GO; GO:0045785; P:positive regulation of cell adhesion; IEA:Ensembl.
DR GO; GO:2000179; P:positive regulation of neural precursor cell proliferation; IEA:Ensembl.
DR GO; GO:0035025; P:positive regulation of Rho protein signal transduction; IEA:Ensembl.
DR GO; GO:0070528; P:protein kinase C signaling; IEA:Ensembl.
DR GO; GO:0007266; P:Rho protein signal transduction; IEA:Ensembl.
DR GO; GO:0072520; P:seminiferous tubule development; IEA:Ensembl.
DR GO; GO:0010573; P:vascular endothelial growth factor production; IEA:Ensembl.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR040950; ADGRG1_GAIN_A.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR003910; GPR1/GPR3/GPR5.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR040679; PLL.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF318; ADHESION G-PROTEIN COUPLED RECEPTOR G1; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF18619; GAIN_A; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF18587; PLL; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01422; GPR56ORPHANR.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..687
FT /note="Adhesion G-protein coupled receptor G1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015331670"
FT TRANSMEM 405..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 439..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 471..489
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 509..531
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 569..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 603..625
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 631..653
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 403..656
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 664..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 687 AA; 77063 MW; CBA85ECF967896A1 CRC64;
MTAQSLLQTT LFLLSLLFLV QGAHGRGHRE DFRFCSQRNQ THRSSLHYKP TPDLRISIEN
SEEALTVHAP FPAAHPASRS FPDPRGLYHF CLYWNRHAGR LHLLYGKRDF LLSDKASSLL
CFQHQEESLA QGPLLLATSV TSWWSPQNIS LPSAASFTFS FHSPPHTAAH NASVDMCELK
RDLQLLSQFL KHPQKASRRP SAAPASQQLQ SLESKLTSVR FTGDTVSFEE DRINATVWKL
QPTAGLQDLH IHSRQEEEQS EILEYSVLLP RTLFQRTKGR RGEAEKRLLL VDFSSQALFQ
DKNSSQVLGE KVLGIVVQNT KVDNLTEPVV LTFQHQLQPK NVTLQCVFWV EDPTLSSPGH
WSSAGCETVR RETQTSCLCN HLTYFAVLMV SSVEVDAVHK HYLSLLSYVG CVVSALACVV
TIAAYLCSRR KPRDYTIKVH MNLLLTVFLL DTSFLLSEPV ALTGSEAGCR ASAIFLHFSL
LACLSWMGLE GYNLYRLVVE VFGTYVPGYL LKLSAMGWGF PIFLVTLVAL VDVDNYGPII
LAVHRTPEGV IYPSMCWIRD SLVSYITNLG LFSLVFLFNM AMLATMVVQI LRLRPHTQKW
SHVLTLLGLS LVLGLPWALI FFSFASGTFQ LVILYLFSII TSFQGFLIFI WYWSMRLQAR
GGPSPLKSNS DSARLPISSG STSSSRI
//
