ID A0A2R8ZYR5_PANPA Unreviewed; 1744 AA.
AC A0A2R8ZYR5;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=A-kinase anchoring protein 12 {ECO:0000313|Ensembl:ENSPPAP00000008097.1};
GN Name=AKAP12 {ECO:0000313|Ensembl:ENSPPAP00000008097.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000008097.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000008097.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000008097.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AJFE02036267; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02036268; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02036269; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02036270; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02036271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02036272; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02036273; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02036274; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02036275; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02036276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPPAT00000030732.1; ENSPPAP00000008097.1; ENSPPAG00000027286.1.
DR GeneTree; ENSGT00730000111244; -.
DR Proteomes; UP000240080; Chromosome 6.
DR Bgee; ENSPPAG00000027286; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051018; F:protein kinase A binding; IEA:InterPro.
DR GO; GO:0010739; P:positive regulation of protein kinase A signaling; IEA:InterPro.
DR GO; GO:0090036; P:regulation of protein kinase C signaling; IEA:InterPro.
DR InterPro; IPR028540; AKAP12.
DR InterPro; IPR001573; AKAP_WSK.
DR InterPro; IPR018459; RII-bd_1.
DR PANTHER; PTHR23209; A-KINASE ANCHOR PROTEIN 12; 1.
DR PANTHER; PTHR23209:SF4; A-KINASE ANCHOR PROTEIN 12; 1.
DR Pfam; PF10522; RII_binding_1; 1.
DR Pfam; PF03832; WSK; 3.
DR PROSITE; PS51893; AKAP_CAM_BD; 3.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|PROSITE-ProRule:PRU01241};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT DOMAIN 571..591
FT /note="A kinase-anchoring proteins AKAP-5 and AKAP-12
FT calmodulin (CaM)-binding"
FT /evidence="ECO:0000259|PROSITE:PS51893"
FT DOMAIN 720..740
FT /note="A kinase-anchoring proteins AKAP-5 and AKAP-12
FT calmodulin (CaM)-binding"
FT /evidence="ECO:0000259|PROSITE:PS51893"
FT DOMAIN 765..785
FT /note="A kinase-anchoring proteins AKAP-5 and AKAP-12
FT calmodulin (CaM)-binding"
FT /evidence="ECO:0000259|PROSITE:PS51893"
FT REGION 39..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 153..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 904..1096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1120..1235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1285..1326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1416..1442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1543..1744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 571..591
FT /note="AKAP CaM-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01241"
FT MOTIF 720..740
FT /note="AKAP CaM-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01241"
FT MOTIF 765..785
FT /note="AKAP CaM-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01241"
FT COMPBIAS 46..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..215
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..243
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..344
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..400
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..433
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..543
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..573
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..604
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..639
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..687
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..749
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 758..773
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 958..980
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 991..1009
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1030..1059
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1069..1083
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1194..1212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1298..1326
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1550..1565
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1567..1590
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1604..1619
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1641..1669
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1672..1691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1692..1717
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1728..1744
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1744 AA; 187643 MW; 766DA6685116B633 CRC64;
APDTTADPAI AASDPATKLL QKNGQLSTIN GVAEQDELSL QEGDLNGQKG ALNGQGALNS
QEEEEVIVTE VGQRDSEDVS ERDSDKEMAA KSAVVHDVTD DGQEETPEII EQIPSSESNL
EELTQPTESQ ANDIGFKKVF KFVGFKFTVK KDKTEKPDTV QLLTVKKDEG EEAAGAGDHQ
DSSLGAGEAA SKESEPKQST EKPEETLKRE QSHAEISPPA ESGQAVEECK VEGEEKQEKE
PSKSAESPTS PVTSETGSTF KKFFTQGWAG WRKKTSFRKP KEDEMEASEK KKEQEPEKVD
TEEDGKAEVA SEKLTASEQA HPREPAESAH EPRLSAEYEK VELPSEEQVS GSQGPSEEKP
APLATEVFDE KIEVHQEEVV AEVHVSTVEE RTEEQKTEVE ETAGSVPAEE LVEMDAEPQE
AEPAKELVKL KETCVSGEDP TQGADLSPDE KVLSKAPEGI VSEVEMLSSQ ERMKVQGSPL
KKLFTSTGLK KLSGKKQKGK RGGGDEESGE HTQVPADSPD SHEEQKGESS ASSPEEPEEI
TCLEKGLAEV QQDGEAEEGA TSDGEKKREG VTPWASFKKM VTPKKRVRRP SESDKEDELD
KVKSATLSST ESAASEMQEE MKGSVEEPKP EEPKRKVDTS VSWEALICVG SSKKRARKGS
SSDEEGGPKA MGGDHHKADE AGKDKETGTD GILAGSQEHD PGQGSSSPEQ AGSPTEGEGV
STWESFKRLV TPRKKSKSKL EEKSEDSIAG SGVDHSTPDT EPGKEESWVS IKKFIPGRRK
KRPDGKQEQA PVEDAGPTGA NEDDSDVPAV VPLSEYDAVE REKMEAQQAQ KSAEQPEQKA
AAEVSKELSE SQVHMMAAAV VDGTRAATII EERSPSWISA SVTEPLEQVE AEAALLTEEV
LEREVIAEEE PPTVTEPLPE NREARGDTVV SEAELTPEAV TAAGPLGAEE GTEASAAEET
TEMVSAVSQL TDSPDTTEEA TPVQEVEGGV PDIEEQERRT QEVLQAVAEK VKEESQLPGT
GGPEDALQPV QRAEAERPEE QAEAPGLKKD TDVVLKVDAQ EAKTEPFTQG KVVGQTTPES
FEKAPQVAES IESSELVTTC QAETLAGVKS QEMVMEQAIP PDSVETPTDS ETDGSTPVAD
FDAPGTTQKD EIVEIHEENE VASGTQSGGT EAEAVPAQKE RPPAPSSFVF QEETKEQSKM
EDTLEHTDKE VSVETVSILS KTEGTQEADQ YADEKTKDVP FVEGLERSID TGITVSREKV
TEVALKGEGT EEAECKKDDA LELQSHAKSA PSPMEREMVV QVEREKTEAE PTHVNEEKLE
HETAVTVSEE VSKQLLQTVN VPIIDGAKEV SSLEGSPPPC LGQEEAVCTK IQVQSSEASF
TLTAAAEEEK VLGETANILE TGETLEPAGA HLVLEEKSSE KNEDFAAHPG EDAVPTGPDC
QAKSTPVIVS ATTKKVLSSD LEGGKTTSLK WKSDEVDEQV ACQEVKVSVA IEEDLEPENG
ILELETKSSK LVQNIIQTAV DQFVRTEGTA TEMLTSELQT QAHVIKADSQ DAGQETEKEG
EEPQASAQDE TPITSAKEES ESTAVGQAHS DISKDMSEAS EKTVTVEVEG STVNDQQLEE
VVLPSEEEGG GAGTKSVPED DGHALLAERI EKSLVEPKGD EKGDDVDDPE NQNSALADTD
ASGGLTKESP DTNGPKQKEK EDAQEVELQE GKVHSESDKA ITPQAQEELQ KQERESAKSE
LTES
//
