ID A0A2R9A0X2_PANPA Unreviewed; 650 AA.
AC A0A2R9A0X2;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=G2/M-phase specific E3 ubiquitin protein ligase {ECO:0000313|Ensembl:ENSPPAP00000010878.1};
GN Name=G2E3 {ECO:0000313|Ensembl:ENSPPAP00000010878.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000010878.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000010878.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000010878.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AJFE02078361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9A0X2; -.
DR STRING; 9597.ENSPPAP00000010878; -.
DR Ensembl; ENSPPAT00000033532.1; ENSPPAP00000010878.1; ENSPPAG00000028644.1.
DR GeneTree; ENSGT00950000182865; -.
DR OMA; FRNQKFN; -.
DR Proteomes; UP000240080; Chromosome 14.
DR Bgee; ENSPPAG00000028644; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd15669; ePHD_PHF7_G2E3_like; 1.
DR CDD; cd15496; PHD_PHF7_G2E3_like; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR042013; PHF7/G2E3_ePHD.
DR InterPro; IPR042012; PHF7/G2E3_PHD.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12420:SF37; G2_M PHASE-SPECIFIC E3 UBIQUITIN-PROTEIN LIGASE; 1.
DR PANTHER; PTHR12420; PHD FINGER PROTEIN; 1.
DR Pfam; PF13771; zf-HC5HC2H; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS51805; EPHD; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 41..158
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
SQ SEQUENCE 650 AA; 74088 MW; 3376B8C20D0816CA CRC64;
MLIPALQISD SESVGLEDGI EQSAYLTESK MNESKPGDSQ NLACVFCRKN DDCPNKYGEK
KTKEKWNLTV HYYCLLMSSG IWQRGKEEEG VYGFLIEDIR KEVNRASKLK CCVCKKNGAS
IGCVAPRCKR SYHFPCGLQR ECIFQFTGNF ASFCWDHRPV QIITSNNYRE SLPCTICLEF
IEPIPSYNIL RSPCCKNAWF HRDCLQVQAI NAGVFFFRCT ICNNSDIFQK EMLRMGIHIP
EKDASWELEE NAYQELLQHY EHCDVRRCRC KEGRDYNAPD SKWEIKRCHC CGSSGTHLAC
SSLRSWEQNW ECLECRGIIY NSGEFQKAKK HVLPNSNNVG ITDCLLEESS PKLPRQSPGS
QSKDLLRQGS KFRRNVSTLL IELGFQIKKT KRLYINKANI WNSALDAFRN RNFNPSYAIE
VAYVIENDNF GSEHPGSKQE FLSLLMQHLE NSSLFEGSLS KNLSLNSQAL KENLYYEAGK
MLAISLVHGG PSPGFFSKTL FNCLVYGPEN TQPILDDVSD FDVAQIIIRI NTATTVADLK
SIINECYNYL ELIGCLRLIT TLSDKYMLVK DILGYHVIQR VHTPFESFKQ GLKTLGVLEK
IQAYPEAFCS ILCHKPESLS AKILSELFTV HTLPDVKALG FWNSYLQAVE
//
