ID A0A2R9A170_PANPA Unreviewed; 902 AA.
AC A0A2R9A170;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=SH3 and PX domains 2B {ECO:0000313|Ensembl:ENSPPAP00000010588.1};
GN Name=SH3PXD2B {ECO:0000313|Ensembl:ENSPPAP00000010588.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000010588.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000010588.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000010588.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the SH3PXD2 family.
CC {ECO:0000256|ARBA:ARBA00009628}.
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DR EMBL; AJFE02044915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02044916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02044917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02044918; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02044919; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9A170; -.
DR STRING; 9597.ENSPPAP00000010588; -.
DR Ensembl; ENSPPAT00000033240.1; ENSPPAP00000010588.1; ENSPPAG00000028491.1.
DR GeneTree; ENSGT00940000158396; -.
DR Proteomes; UP000240080; Chromosome 5.
DR Bgee; ENSPPAG00000028491; Expressed in placenta and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0060348; P:bone development; IEA:Ensembl.
DR GO; GO:0022617; P:extracellular matrix disassembly; IEA:Ensembl.
DR GO; GO:0001654; P:eye development; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0072657; P:protein localization to membrane; IEA:Ensembl.
DR GO; GO:0006801; P:superoxide metabolic process; IEA:Ensembl.
DR CDD; cd06888; PX_FISH; 1.
DR CDD; cd12075; SH3_Tks4_1; 1.
DR CDD; cd12076; SH3_Tks4_2; 1.
DR CDD; cd12078; SH3_Tks4_3; 1.
DR CDD; cd12018; SH3_Tks4_4; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 4.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR037961; SH3PXD2_PX.
DR InterPro; IPR035477; SH3PXD2B_SH3_1.
DR InterPro; IPR035478; SH3PXD2B_SH3_2.
DR InterPro; IPR035479; SH3PXD2B_SH3_3.
DR InterPro; IPR035480; SH3PXD2B_SH3_4.
DR PANTHER; PTHR15706:SF25; SH3 AND PX DOMAIN-CONTAINING PROTEIN 2B; 1.
DR PANTHER; PTHR15706; SH3 MULTIPLE DOMAIN; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF00018; SH3_1; 3.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00326; SH3; 4.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 4.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50002; SH3; 4.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..120
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 143..202
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 212..271
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 359..418
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 841..902
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 266..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..341
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..540
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..581
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..617
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..761
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 902 AA; 100247 MW; C41725DAB937E2B9 CRC64;
MCRPPPPPLI QVGELKVYII RVTWSSGSTE AIYRRYSKFF DLQMQMLDKF PMEGGQKDPK
QRIIPFLPGK ILFRRSHIRD VAVKRLIPID EYCKALIQLP PYISQCDEVL QFFETRPEDL
NPPKECHVCF LSTGGDQTSV DPMVLEQYVV VANYQKQESS EISLSVGQVV DIIEKNESGW
WFVSTAEEQG WVPATCLEGQ DGVQDEFSLQ PEEEEKYTVI YPYTARDQDE MNLERGAVVE
VIQKNLEGWW KIRYQGKEGW APASYLKKNS GEPLPPKPGP GSPSHPGALD LDGVSRQQNA
VGREKELLSS QRDGRFEGRP VPDGDAKQRS PKMRQRPPPR RDMTIPRGLN LPKPPIPPQV
EEEYYTIAEF QTTIPDGISF QAGLKVEVIE KNLSGWWYIQ IEDKEGWAPA TFIDKYKKTS
NASRPNFLAP LPHEVTQLRL GEAAALENNT GSEATGPSRP LPDAPHGVMD SGLPWSKDWK
GSKDVLRKAS SDMSASAGYE EISDPDMEEK PSLPPRKESI IKSEGELLER ERERQRTEQL
RGPTPKPPGM ILPMMPAKHT PPARDSRRPE PKPDKSKLFQ LKNDMGLECG HKVLAKEVKK
PNLRPISKSK TDLPEEKPDA TPQNPFLKSR PQVRPKPAPS PKTEPPQGED QVDICNLRSK
LRPAKSQDKS LLDGEGPQAV GGQDVAFSRS FLPGEGSGRA QDRTGKQDGL SPKEISCRAP
PRPAKTTDPV SKSVPVPLQE APQQRPVVPP RRPPPPKKTS SSSRPLPEVR GPQCEGHESR
AAPTPGRALL VPPKAKPFLS NSLGGQDDTR GKGSLGPWGT GKIGENREKA AAASVPSADG
LKDSLYVAVA DFEGDKDTSS FQEGTVFEVR EKNSSGWWFC QVLSGAPSWE GWIPSNYLRK
KP
//
