ID A0A2R9A1A4_PANPA Unreviewed; 948 AA.
AC A0A2R9A1A4;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=PHD finger protein 8 {ECO:0000313|Ensembl:ENSPPAP00000011037.1};
GN Name=PHF8 {ECO:0000313|Ensembl:ENSPPAP00000011037.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000011037.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000011037.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000011037.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AJFE02016064; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02016065; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02016066; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02016067; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02016068; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02016069; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02016070; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02016071; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02016072; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02016073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008974777.1; XM_008976529.2.
DR AlphaFoldDB; A0A2R9A1A4; -.
DR Ensembl; ENSPPAT00000033692.1; ENSPPAP00000011037.1; ENSPPAG00000028713.1.
DR GeneTree; ENSGT00940000157847; -.
DR OMA; DIFHQNI; -.
DR OrthoDB; 2784357at2759; -.
DR Proteomes; UP000240080; Chromosome X.
DR Bgee; ENSPPAG00000028713; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0141052; F:histone H3 demethylase activity; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProt.
DR CDD; cd15642; PHD_PHF8; 1.
DR Gene3D; 1.20.58.1360; -; 1.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR InterPro; IPR041070; JHD.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR PANTHER; PTHR23123:SF11; HISTONE LYSINE DEMETHYLASE PHF8; 1.
DR PANTHER; PTHR23123; PHD/F-BOX CONTAINING PROTEIN; 1.
DR Pfam; PF17811; JHD; 1.
DR Pfam; PF02373; JmjC; 1.
DR Pfam; PF00628; PHD; 1.
DR SMART; SM00558; JmjC; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 5..56
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 195..351
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT REGION 63..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 631..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 777..904
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..673
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..741
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..895
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 948 AA; 105910 MW; 3B1CF8F097527CDF CRC64;
MASVPVYCLC RLPYDVTRFM IECDMCQDWF HGSCVGVEEE KAADIDLYHC PNCEVLHGPS
IMKKRRGSSK GHDTHKGKPV KTGSPTFVRE LRSRTFDSSD EVILKPTGNQ LTVEFLEENS
FSVPILVLKK DGLGMTLPSP SFTVRDVEHY VGSDKEIDVI DVTRQADCKM KLGDFVKYYY
SGKREKVLNV ISLEFSDTRL SNLVETPKIV RKLSWVENLW PEECVFERPN VQKYCLMSVR
DSYTDFHIDF GGTSVWYHVL KGEKIFYLIR PTNANLTLFE CWSSSSNQNE MFFGDQVDKC
YKCSVKQGQT LFIPTGWIHA VLTPVDCLAF GGNFLHSLNI EMQLKAYEIE KRLSTADLFR
FPNFETICWY VGKHILDIFR GLRENRRHPA SYLVHGGKAL NLAFRAWTRK EALPDHEDEI
PETVRTVQLI KDLAREIRLV EFNITGACLN DSDDDSPDLD LDGDESPLAL LMSNGSTKRV
KSLSKSRRTK IAKKVDKARL MAEQVMEDEF DLDSDDELQI DERLGKEKAT LIIRPKFPRK
LPRAKPCSDP NRVREPGEVE FDIEEDYTTD EDMVEGVEGK LGNGSGAGGI LDLLKASRQV
GGPDYAALTE APASPSTQEA IQGMLCMANL QSSSSSPATS SLQAWWTGGQ DRSSGSSSSG
LGTVSNSPAS QRTPGKRPIK RPAYWRTESE EEEENASLDE QDSLGACFKD AEYIYPSLES
DDDDPALKSR PKKKKNSDDA PWSPKARVTP TLPKQDRPVR EGTRVASIET GLAAAAAKLA
QQELQKAQKK KYIKKKPLLK EVEQPRPQDS NLSLTVPAPP VAATPQLVTS SSPLPPPEPK
QEALSGSLAD HEYTARPNAF GMAQANRSTT PMAPGVFLTQ RRPSVGSQSN QAGQGKRPKK
GLATAKQRLG RILKIHRNGK LLLRQVIVQA ECRQAIHEPK LKRRDAHP
//
