ID A0A2R9A584_PANPA Unreviewed; 805 AA.
AC A0A2R9A584;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Hypoxia-inducible factor 1-alpha {ECO:0000256|ARBA:ARBA00014446};
GN Name=HIF1A {ECO:0000313|Ensembl:ENSPPAP00000010910.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000010910.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000010910.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000010910.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
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DR EMBL; AJFE02111809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02111810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02111811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02111812; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9A584; -.
DR Ensembl; ENSPPAT00000033564.1; ENSPPAP00000010910.1; ENSPPAG00000028617.1.
DR GeneTree; ENSGT00940000156774; -.
DR Proteomes; UP000240080; Chromosome 14.
DR Bgee; ENSPPAG00000028617; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0001666; P:response to hypoxia; IEA:UniProt.
DR CDD; cd19727; bHLH-PAS_HIF1a_PASD8; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR001321; HIF-1_alpha.
DR InterPro; IPR014887; HIF-1_CTAD.
DR InterPro; IPR021537; HIF_alpha-like.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR013655; PAS_fold_3.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR PANTHER; PTHR23043:SF7; HYPOXIA-INDUCIBLE FACTOR 1-ALPHA; 1.
DR Pfam; PF11413; HIF-1; 1.
DR Pfam; PF08778; HIF-1a_CTAD; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF08447; PAS_3; 1.
DR PRINTS; PR01080; HYPOXIAIF1A.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydroxylation {ECO:0000256|ARBA:ARBA00023278};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 1..54
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 77..142
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 231..282
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 478..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..649
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 386
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000256|PIRSR:PIRSR621537-50"
FT MOD_RES 548
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000256|PIRSR:PIRSR621537-50"
FT MOD_RES 782
FT /note="(3S)-3-hydroxyasparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR621537-50"
SQ SEQUENCE 805 AA; 90580 MW; E4B655F9DA1C7C27 CRC64;
RRKEKSRDAA RSRRSKESEV FYELAHQLPL PHNVSSHLDK ASVMRLTISY LRVRKLLDAG
DLDIEDDMKA QMNCFYLKAL DGFVMVLTDD GDMIYISDNV NKYMGLTQFE LTGHSVFDFT
HPCDHEEMRE MLTHRNGLVK KGKEQNTQRS FFLRMKCTLT SRGRTMNIKS ATWKVLHCTG
HIHVYDTNSN QPQCGYKKPP MTCLVLICEP IPHPSNIEIP LDSKTFLSRH SLDMKFSYCD
ERITELMGYE PEELLGRSIY EYYHALDSDH LTKTHHDMFT KGQVTTGQYR MLAKRGGYVW
VETQATVIYN TKNSQPQCIV CVNYVVSGII QHDLIFSLQQ TECVLKPVES SDMKMTQLFT
KVESEDTSSL FDKLKKEPDA LTLLAPAAGD TIISLDFGSN DTETDDQQLE EVPLYNDVML
PSPNEKLQNI NLAMSPLPTA ETPKPLRSSA DPALNQEVAL KLEPNPESLE LSFTMPQIQD
QTPSPSDGST RQSSPEPNSP SEYCFYVDSD MVNEFKLELV EKLFAEDTEA KNPFSTQDTD
LDLEMLAPYI PMDDDFQLRS FDQLSPLESS SASPESAITV FQQTQIQEPT ANATTTTATT
DELKTVTKDR MEDIKILIAS PSPTHIHKET TSATSSPYRD TQSRTASPNR AGKGVIEQTE
KSHPRSPNVL SVALSQRTTV PEEELNPKIL ALQNAQRKRK MEHDGSLFQA VGIGTLLQQP
DDHAATTSLS WKRVKGCKSS EQNGMEQKTI ILIPSDLACR LLGQSMDESG LPQLTSYDCE
VNAPIQGSRN LLQGEELLRA LDQVN
//
