ID A0A2R9A610_PANPA Unreviewed; 1531 AA.
AC A0A2R9A610;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Deleted in malignant brain tumors 1 protein {ECO:0000256|ARBA:ARBA00014650};
DE AltName: Full=Hensin {ECO:0000256|ARBA:ARBA00030560};
GN Name=DMBT1 {ECO:0000313|Ensembl:ENSPPAP00000012329.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000012329.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000012329.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000012329.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DMBT1 family.
CC {ECO:0000256|ARBA:ARBA00009931}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJFE02055358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02055359; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02055360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02090507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02090508; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPPAT00000034993.1; ENSPPAP00000012329.1; ENSPPAG00000029246.1.
DR GeneTree; ENSGT00950000183145; -.
DR OMA; IYHYGGQ; -.
DR Proteomes; UP000240080; Chromosome 10.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 2.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR Gene3D; 3.10.250.10; SRCR-like domain; 7.
DR Gene3D; 2.60.40.4100; Zona pellucida, ZP-C domain; 1.
DR Gene3D; 2.60.40.3210; Zona pellucida, ZP-N domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR InterPro; IPR042235; ZP-C.
DR InterPro; IPR001507; ZP_dom.
DR InterPro; IPR017977; ZP_dom_CS.
DR PANTHER; PTHR19331:SF22; DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN; 1.
DR PANTHER; PTHR19331; SCAVENGER RECEPTOR DOMAIN-CONTAINING; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF00530; SRCR; 7.
DR Pfam; PF00100; Zona_pellucida; 1.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00202; SR; 7.
DR SMART; SM00241; ZP; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR SUPFAM; SSF56487; SRCR-like; 7.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS00420; SRCR_1; 6.
DR PROSITE; PS50287; SRCR_2; 7.
DR PROSITE; PS00682; ZP_1; 1.
DR PROSITE; PS51034; ZP_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00196}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1531
FT /note="Deleted in malignant brain tumors 1 protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015361604"
FT DOMAIN 102..202
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 234..334
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 363..463
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 494..594
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 634..734
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 765..865
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 891..1002
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1008..1111
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 1133..1242
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1251..1499
FT /note="ZP"
FT /evidence="ECO:0000259|PROSITE:PS51034"
FT REGION 604..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 127..191
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 140..201
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 171..181
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 259..323
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 272..333
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 303..313
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 388..452
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 401..462
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 432..442
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 519..583
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 532..593
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 563..573
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 659..723
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 672..733
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 703..713
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 790..854
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 803..864
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 834..844
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1036..1100
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1049..1110
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 1080..1090
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ SEQUENCE 1531 AA; 167119 MW; 59D73DD88581425A CRC64;
MGISTVILEM CLLWGQVLST GGWIPRATDY ASLIPSEVPL DTTVAEGSPF PSKLTLESTV
AEGSPISLES TLESTVAEGS LIPSESTLES TVAEGSDSGL ALRLVNGDGR CQGRVEILYR
GSWGTVCDDS WDTNDANVVC RQLGCGWAMS APGNARFGQG SGPIVLDDVR CSGHESYLWS
CPHNGWLSHN CGHGEDAGVI CSAAQPQSTL RPESWPVSIS PPVPTEGSES SLALRLVNGG
DRCRGRVEVL YRGSWGTVCD DYWDTNDANV VCRQLGCGWA MSAPGNAQFG QGSGPIVLDD
VRCSGHESYL WSCPHNGWLT HNCGHSEDAG VICSVSQSRP TPSPDTWPTS RASTAGSESS
LALRLVNGGD RCQGRVEVLY RGSWGTVCDD SWDTSDANVV CRQLGCGWAT SAPGNARFGQ
GSGPIVLDDV RCSGYESYLW SCPHNGWLSH NCQHSEDAGV ICSAAHSWST PRPDTLPTIT
LPASTVGSES TLALRLVNGG DRCQGRVEVL YRGSWGTVCD DYWDTNDANV VCRQLGCGWA
MSAPGNARFG QGSGPIVLDD VRCSGHESYL WSCPHNGWLT HNCGHSEDAG VICLASQSRL
TPSPETWPTS RASTADTWPT SRASTAGSES TLALRLVNGG DRCRGRVEVL YRGSWGTVCD
DYWDTNDANV VCRQLGCGWA TSAPGNARFG QGSGPIVLDD VRCSGHEFYL WSCPHNGWLS
HNCGHHEDAG VICSAAQSQS TPRPDTWLTT NLPAPPIGSE SSLALRLVNG GDRCRGRVEV
LYRGSWGTVC DDSWDTNDAN VVCRQLGCGW AMSAPGNARF GQGSGPIVLD DVRCSGNESY
LWSCPHNGWL THNCGHHEDA GVICSATQIN STTTDWWHPT TTTTARPSSN CGGFLFYASG
TLSSPSYPAY YPNNAKCVWE IEVNSGYRIN LGFSNLKLEA HHNCSFDYVE IFDGSLNSSL
LLGKICNDTR QIFTSSYNRM TIHFRSDISF QNTGFLAWYN SFPSDATLRL VNLNSSYGLC
AGRVEIYHGG TWGTVCDDSW TIQEAEVVCR QLGCGRAVSA LGNAYFGSGS GPITLDDVEC
SGTESTLWQC RNRGWFSHNC NHREDAGVIC SGNQLSTPAP FLNITRPNTD YSCGGFLSQP
SGGFSSPFYP GNYPNNAKCV WDIEVQNNYR VTVIFRDVQL EGGCNYDYIE VFDGPYRNSP
LIARVCDGAR GSFTSSSNFM SIRFISDHSI TRRGFRAEYY SSPSNDSTNL LCLPNHMQAS
VSRSYLQSLG FSASDLVIST WNGYYECRPQ ITPNLVIFTI PYSGCGTFKQ ADNDTIDYSN
FLTAAVSGGI IKRRTDLRIH VSCRMLHNTW VDTMYIANDT IQVEEVQYGN FDVNISFYTS
SSFLYPVTSR PYYVDLNQDL YVQAEILHSD AVLTLFVDTC VASPYSNDFT SLTYDLIRSG
CVRDDTYGPY SSPSLRIARF RFRAFHFLNR FPSVYLRCKM VVCRAYDPSS RCYRGCVLRS
KRDVGSYQEK VDVVLGPIQL QTPPRREEEP R
//
