ID A0A2R9A6D5_PANPA Unreviewed; 704 AA.
AC A0A2R9A6D5;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Aminopeptidase O (putative) {ECO:0000313|Ensembl:ENSPPAP00000011250.1};
GN Name=AOPEP {ECO:0000313|Ensembl:ENSPPAP00000011250.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000011250.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000011250.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000011250.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the peptidase M1 family.
CC {ECO:0000256|ARBA:ARBA00010136}.
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DR EMBL; AJFE02034847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02034848; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02034849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02034850; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02034851; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02034852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02034853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02034854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02034855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02034856; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9A6D5; -.
DR Ensembl; ENSPPAT00000033905.1; ENSPPAP00000011250.1; ENSPPAG00000028823.1.
DR GeneTree; ENSGT00940000155211; -.
DR Proteomes; UP000240080; Chromosome 9.
DR Bgee; ENSPPAG00000028823; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0005730; C:nucleolus; IEA:InterPro.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR Gene3D; 1.25.40.320; Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain; 1.
DR Gene3D; 2.60.40.1730; tricorn interacting facor f3 domain; 1.
DR InterPro; IPR042097; Aminopeptidase_N-like_N_sf.
DR InterPro; IPR033577; AOPep.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR038502; M1_LTA-4_hydro/amino_C_sf.
DR InterPro; IPR015211; Peptidase_M1_C.
DR InterPro; IPR014782; Peptidase_M1_dom.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR PANTHER; PTHR46627; AMINOPEPTIDASE O; 1.
DR PANTHER; PTHR46627:SF1; AMINOPEPTIDASE O; 1.
DR Pfam; PF09127; Leuk-A4-hydro_C; 1.
DR Pfam; PF01433; Peptidase_M1; 1.
DR SMART; SM01263; Leuk-A4-hydro_C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF63737; Leukotriene A4 hydrolase N-terminal domain; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT DOMAIN 557..703
FT /note="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase
FT C-terminal"
FT /evidence="ECO:0000259|SMART:SM01263"
SQ SEQUENCE 704 AA; 80375 MW; 24D9A5219136D5DF CRC64;
MDIQLDPARD DLPLMANTSH ILVKHYVLDL DVDFESQVIE GTIVLFLEDG NRFKKQNSSI
EEACQSESNK ACKFGMPEPC HIPVTNARTF SSEMEYNDFA ICSKGEKDTS DKDGNHDNQE
HASGISSSKY CCDTGNHGSE DFLLVLDCCD LSVLKVEEVD VAAVPGLEKF TRSPELTVVS
EEFRNQIVRE LVTLPANRWR EQLDYYACCS QAPGCGELLF DTDTWSLQIR KTGAQTATDF
PHAIRIWYKT KPEGRSVTWT SDQSGRPCVY TVGSPINNRA LFPCQEPPVA MSTWQATVRA
AASFVVLMSG ENSAKPTQLW EGCSSWYYYV TMPMPASTFT IAVGCWTEMK METWSSNDLA
TERPFSPSEA NFRHVGVCSH MEYPCRFQNA SATTQEIIPH RVFAPVCLTG ACQETLLRLI
PPCLSAAHSV LGTHPFSRLD VLIVPANFPS LGMARPSKDK TGHTSDSGAS VIKHGLNPEK
IFMQVHYLKG YFLLWFLAKR LGDETYFSFL RKFVHTFHGQ LILSQDFLQM LLENIPEEKR
LELSVENIHQ DWLESSGIPK QVRAEVTKWI RVNRRPRKRK RREKEEVFEK LLPDQLVLLL
EHLLEQKTLS PRTLQSLQRT YHLQDQDAEV RHRWCELIVK HKFTKAYKNV ERFLQEDQAM
GVYLYGELMV SEDARQQQLA RRCFERTKEQ MDRSSAQVVA EMLF
//
