ID A0A2R9A6R7_PANPA Unreviewed; 398 AA.
AC A0A2R9A6R7;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Lymphocyte transmembrane adaptor 1 {ECO:0000313|Ensembl:ENSPPAP00000012984.1};
GN Name=LAX1 {ECO:0000313|Ensembl:ENSPPAP00000012984.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000012984.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000012984.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000012984.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AJFE02080251; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02080252; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02080253; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003823030.1; XM_003822982.3.
DR AlphaFoldDB; A0A2R9A6R7; -.
DR STRING; 9597.ENSPPAP00000012984; -.
DR Ensembl; ENSPPAT00000035652.1; ENSPPAP00000012984.1; ENSPPAG00000029666.1.
DR GeneID; 100988164; -.
DR KEGG; pps:100988164; -.
DR CTD; 54900; -.
DR GeneTree; ENSGT00390000014063; -.
DR OMA; RDYINVP; -.
DR OrthoDB; 4630544at2759; -.
DR Proteomes; UP000240080; Chromosome 1.
DR Bgee; ENSPPAG00000029666; Expressed in heart and 2 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0042169; F:SH2 domain binding; IEA:Ensembl.
DR GO; GO:0050851; P:antigen receptor-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0042113; P:B cell activation; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
DR GO; GO:0050868; P:negative regulation of T cell activation; IEA:Ensembl.
DR InterPro; IPR031393; LAX.
DR PANTHER; PTHR24091; LYMPHOCYTE TRANSMEMBRANE ADAPTER 1; 1.
DR PANTHER; PTHR24091:SF0; LYMPHOCYTE TRANSMEMBRANE ADAPTER 1; 1.
DR Pfam; PF15681; LAX; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 38..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 228..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..330
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 398 AA; 44058 MW; 3BFD427966CEADAA CRC64;
MDGVTPTLST IRGRTLESST LHVTPRSLDR NKDQITNIFS GFAGLLAILL VVAVFCILWN
WNKRKKRQVP YLRVTVMPLL TLPQTRQRAK NIYDILPWRQ EDLGRHESRS MRIFSTESLL
SRNSESPEHV PSQAGSAFQE HTAHIHATEY AVGIYDNAMV PQMCGNLTPS AHCINVRASR
DCASISSEDS HDYVNVPTAE EIAETLASTK SPSRNLFVLP STQKLEFTEE RDEGCGDAGD
CTSLYSPGAE DSDSLSNGEG SSQISNDYVN MTGLDLSAIQ ERQLWVAFQC CRDYENVPAA
DPSGSQQQAE KDVPSSNIGH VEDKTDDPGT HVQCVKRTFL ASGDYADFQP FTQSEDSQMK
HREEMSNEDS SDYENVLTAK LGGRDSEQGP GTQLLPDE
//
