ID A0A2R9A7B1_PANPA Unreviewed; 431 AA.
AC A0A2R9A7B1;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=MEFV innate immunity regulator, pyrin {ECO:0000313|Ensembl:ENSPPAP00000011291.1};
GN Name=MEFV {ECO:0000313|Ensembl:ENSPPAP00000011291.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000011291.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000011291.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000011291.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AJFE02049897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02049898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02049899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02049900; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9A7B1; -.
DR Ensembl; ENSPPAT00000033946.1; ENSPPAP00000011291.1; ENSPPAG00000028835.1.
DR GeneTree; ENSGT00940000161955; -.
DR Proteomes; UP000240080; Chromosome 16.
DR Bgee; ENSPPAG00000028835; Expressed in testis and 5 other cell types or tissues.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08321; Pyrin_ASC-like; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000315; Znf_B-box.
DR PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR PANTHER; PTHR24103:SF606; PYRIN; 1.
DR Pfam; PF02758; PYRIN; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00024};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00024};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00024}.
FT DOMAIN 1..92
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 159..201
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT REGION 127..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 431 AA; 49146 MW; A63958FABEE72AB2 CRC64;
MAKTPSDHLL STLEELVPYD FEKFRFKLQN TSVQKEHSRI PRSQIQRARP VKMATLLVTY
YGEEYAVQLT LQVLRAINQR LLAEELHRAA IQGRPPDTAA SPRCHAQEGD PVGGTCVRDS
CSFPEAVSGH PQASGSRSPG CPRCQDSHER KSPGSLSPQP LPQCKRHLKQ VQLLFCEDHD
EPICLICSLS QEHQGHRVRP IEEVALEHKK KIQKQLEHLK KLRKSGEEQR SYGEEKAVSF
LKQTEALKQR VQRKLEQVYY FLEQQEHFFV ASLEDVGQMV GQIRKAYDTR VSQDIALLDA
LIGELEAKEC QSEWELLQVG SFVSRAKTVR VPEQWTTPQE IKQKIQLLHQ KSEFVEKSTK
YFSETLRSEM EMFNDHSPQH GLGSWEEWDY TQHSMQGPKQ GVPCLSLTVH MTYSLAVPCG
GSCLIPDSPL L
//
