ID A0A2R9A7N3_PANPA Unreviewed; 1338 AA.
AC A0A2R9A7N3;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Neurofascin {ECO:0000313|Ensembl:ENSPPAP00000011670.1};
GN Name=NFASC {ECO:0000313|Ensembl:ENSPPAP00000011670.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000011670.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000011670.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000011670.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR EMBL; AJFE02080180; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02080181; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02080182; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02080183; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02080184; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9597.ENSPPAP00000011670; -.
DR Ensembl; ENSPPAT00000034331.1; ENSPPAP00000011670.1; ENSPPAG00000028903.1.
DR GeneTree; ENSGT00940000157024; -.
DR Proteomes; UP000240080; Chromosome 1.
DR Bgee; ENSPPAG00000028903; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 5.
DR CDD; cd05731; Ig3_L1-CAM_like; 1.
DR CDD; cd05845; IgI_2_L1-CAM_like; 1.
DR CDD; cd05875; IgI_hNeurofascin_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR InterPro; IPR026965; NFASC_Ig-like.
DR PANTHER; PTHR44170:SF12; NEUROFASCIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 5.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 6.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 5.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1338
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015343137"
FT TRANSMEM 1208..1229
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..134
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 140..227
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 241..329
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 334..421
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 426..514
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 518..600
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 627..722
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 727..820
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 825..927
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 931..1030
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1105..1197
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 710..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 912..932
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1008..1038
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1081..1102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1239..1338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1239..1263
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1265..1286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1309..1323
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1324..1338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1338 AA; 149250 MW; 851F44EA7BC58740 CRC64;
MARQPPPPWV HAAFLLCLLS LGGAIEIPMD RESLTQPPTI TKQSVKDHIV DPRDNILIEC
EAKGNPAPSF HWTRNSRFFN IAKDPRVSMR RRSGTLVIDF RSGGRPEEYE GEYQCFARNK
FGTALSNRIR LQVSKSPLWP KENLDPVVVQ EGAPLTLQCN PPPGLPSPVI FWMSSSMEPI
TQDKRVSQGH NGDLYFSNVM LQDMQTDYSC NARFHFTHTI QQKNPFTLKV LTTRGVAERT
PSFMYPQGTA SSQMVLRGMD LLLECIASGV PTPDIAWYKK GGDLPSDKAK FENFNKALRI
TNVSEEDSGE YFCLASNKMG SIRHTISVRV KAAPYWLDEP KNLILAPGED GRLVCRANGN
PKPTVQWMVN GEPLQSAPPN PNREVAGDTI IFRDTQISSR AVYQCNTSNE HGYLLANAFV
SVLDVPPRML SPRNQLIRVI LYNRTRLDCP FFGSPIPTLR WFKNGQGSNL DGGNYHVYEN
GSLEIKMIRK EDQGIYTCVA TNILGKAENQ VRLEVKDPTR IYRMPEDQVA KRGTTVQLEC
RVKHDPSLKL TVSWLKDDEP LYIGNRMKKE DDSLTIFGVA ERDQGSYTCV ASTELDQDLA
KAYLTVLADQ ATPTNRLAAL PKGRPDRPRD LELTDLAERS VRLTWIPGDA NNSPITDYVV
QFEEDQFQPG VWHDHSKYPG SVNSAVLRLS PYVNYQFRVI AINEVGSSHP SLPSERYRTS
GAPPESNPGD VKGEGTRKNN MEITWTPMNA TSAFGPNLRY IVKWRRRETR EAWNNVTVWG
SRYVVGQTPV YVPYEIRVQA ENDFGKGPEP ESVIGYSGED YPRAAPTEVK VRVMNSTAIS
LQWNRVYSDT VQGQLREYRA YYWRESSLLK NLWVSQKRQQ ASFPGDRLRG MVSRLFPYSN
YKLEMVVVNG RGDGPRSETK EFTTPEGVPS APRRFRVRQP NLETINLEWD HPEHPNGIMI
GYTLKYVAFN GTKVGKQIVE NFSPNQTKFT VQRTDPVSRY RFTLSARTQV GSGEAVTEES
PAPPNEAPPT LPPTTVGATG AVSSTDATAI AATTEATTVP IIPTVAPTTI ATTTVATTTT
TTAATTTTTE SPPTTTSGTK IHESAPDEQS IWNVTVLPNS KWANITWKHN FGPGTDFVVE
YIDSNHTKKT VPVKAQAQPI QLTDLYPGMT YTLRVYSRDN EGISSTVITF MTSTAYTNNQ
ADIATQGWFI GLMCAIALLV LILLIVCFIK RSRGGKYPVR EKKDVPLGPE DPKEEDGSFD
YSDEDNKPLQ GSQTSLDGTI KQQESDDSLV DYGEGGEGQF NEDGSFIGQY TVKKDKEETE
GNESSEATSP VNAIYSLA
//
