ID A0A2R9A831_PANPA Unreviewed; 3542 AA.
AC A0A2R9A831;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Spectrin repeat containing nuclear envelope protein 2 {ECO:0000313|Ensembl:ENSPPAP00000011561.1};
GN Name=SYNE2 {ECO:0000313|Ensembl:ENSPPAP00000011561.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000011561.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000011561.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000011561.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nesprin family.
CC {ECO:0000256|ARBA:ARBA00008619}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJFE02111709; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02111710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02111711; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02111712; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02111713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02111714; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02111715; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02111716; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02111717; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPPAT00000034219.1; ENSPPAP00000011561.1; ENSPPAG00000028821.1.
DR GeneTree; ENSGT00940000154656; -.
DR OMA; THTEMGR; -.
DR Proteomes; UP000240080; Chromosome 14.
DR Bgee; ENSPPAG00000028821; Expressed in adult mammalian kidney and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProt.
DR CDD; cd00176; SPEC; 5.
DR Gene3D; 1.20.58.60; -; 10.
DR InterPro; IPR039906; Anc-1/SYNE1/2-like.
DR InterPro; IPR012315; KASH.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR21524; SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2; 1.
DR PANTHER; PTHR21524:SF6; SPECTRIN REPEAT-CONTAINING NUCLEAR ENVELOPE PROTEIN 2; 1.
DR Pfam; PF10541; KASH; 1.
DR Pfam; PF00435; Spectrin; 3.
DR SMART; SM01249; KASH; 1.
DR SMART; SM00150; SPEC; 15.
DR SUPFAM; SSF46966; Spectrin repeat; 13.
DR PROSITE; PS51049; KASH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00385}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00385}; Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT TOPO_DOM 1..3491
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT TOPO_DOM 3513..3542
FT /note="Perinuclear space"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT DOMAIN 3483..3542
FT /note="KASH"
FT /evidence="ECO:0000259|PROSITE:PS51049"
FT REGION 707..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 818..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 969..997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1051..1082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2988..3070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3121..3178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3425..3455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 326..353
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 491..539
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 632..693
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1132..1159
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1302..1329
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2446..2512
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 752..766
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..847
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..988
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2988..3020
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3136..3150
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3542 AA; 408988 MW; 04839C69800DE673 CRC64;
IEEDIYTNLS KMETVLGQSM SSLPLSYREA LERLEQSKAL VSNLISTKEE LMKLRQILRL
LRLRCTENDG ICLLKIVSAL WEKWLSLLEA AKEWEMWCEE LKQEWKFVSE EIEREAIILD
NLQEELPEIS KTKEAATTEE LSELLDCLCQ YGENVEKQQL LLTLLLQRIR SIQNVPESSG
AVETVPAFQE ITSMKERCNK LLQKVQKNKE LVQTEIQERH SFTKEIIALK NFFQQATTSF
QNMAFQDHPE KSEQFEELQS ILKKGKLTFE NIMEKLRIKY SEMYTIVPAE IESQVEECRK
ALEDIDEKIS NEVLKSSPSY AMRRKIEEIN NGLHNVEKML QQKSKNIEKA QEIQKKMWDE
LDLWHSKLNE LDSEVQDIVE QDPGQAQEWM DNLMIPFQQY QQVSQRAECR TSQLNKATVK
MEEYSDLLKS TEAWIENTSH LLANPADYDS LRTLSHHAST LQMALEDSEQ KHNLLHSIFM
DLEDLSIIFE TDELTQSIQE LSNQVTALQQ KIMESLPQIQ RMADDMVAIE SEVKSMEKRV
SKIKTILLSK EIFDFSPEEH LKHGEVILEN IRPMKKTIAE IVSYQVELRL PQTGMKPLPV
FQRTNQLLQD IKLLENMTQE QNELLKVVIK QTNECDEEIE NLKQILNNYS AQFSLEHMSP
DQADKLPQLQ GEIERMEKQI LSLNQRKEDL LVDLKATVLN LHQHLKQEQE GVERDRLPAV
TSEEGGVAER DASERKLNRR GSMSYLAAVE EEVEESSVKS ENGDEKAEPS PQSWSSLWKH
DKDMEEDRAS SSSGTIVQEA YGKISTSDNS MAQILTPDSL NTEQGPECSL RPNQTEEGTT
PPIEADTLDS SDAQGGLEPR VEKTRPEPAE VLHACKTQVA ELELWLQQAN VAVEPETLNS
DMQQVLEQQL VGCQAMLTEI EHKVAFLLET CKDQGLGDNG ATQHEAEALS LKLKTVKCNL
EKVQMMLQEK HSEDQHPTIL RKSSEPEHQE ALQPVNLSEL ESIVTERPQF SRQKDFQQQQ
VLELKPMEQK DFIKFIEFNA KKMWPQYCQH DKDTTQESSA SNQATSPEND VPDSILSPQG
QNGDKWQYLH HELSSKIKLP LPQLVEPQVS TNMGILPSVS MYNFRYPTTE ELKTYTTQLE
DLRQEASNLQ TQENMTEEAY INLDKKLFEL FLTLSQCLSS VEEMLEMPRL YREDGSGQQV
HYETLALELK KLYLALSDKK GDLLKAMTWP GKNTNLLLEC FDNLQVCLEH TQAAAVCRSK
SLKAGLDYNR SYQHEIKRLY DQLIKSKTSL QQSLNEISGQ SVAEQLQKAD AYTVELENAE
SRVAKLRDEG ERLHLPYALL QEVYKLEDVL DSMWGMLRAR YTELSGPFVT ESQQDALLQG
MVELVKIGKE KLAHGHLKQT KSKVALQAQI ENHKVFFQKL VADMLLIQAY SAKILPSLLQ
NRETFWAEQV TEVKMLEEKS RQCGMKLQSL LQKWEEFDEN YASLEKDLEI LISTLPSVSL
VEETEERLVE RISFYQQIKR NIGGKHARLY QTLNEGKQLV ASVSCPELEG QIAKLEEQWL
SLNKKIDHEL HRLQALLKHL LSYNRDSDQL TKWLESSQHT LNYWKEQSLN VSQDLDTIRS
NIDNFFEFSK EVDEKSSLKT AVISIGNQLL HLKETDTATL RASLAQFEQK WTMLITQLPD
IQEKLHQLQM EKLPSRKAIT EMISWMNNVE HQTSDEDSMH SPSSASQVKH LLQKHKEFRM
EMDYKQWIVD FVNQSLLQLS TCDVESKRYE RTEFAEHLGE MNRQWHRVHG MLNRKIQHLE
QLLESITESE NKIQILNNWM EAQEERLKTL QKPESVISVQ KLLLDCQDIE NQLAIKSRAL
DELKQSYLTL ESGAVPLLED TASQIDELFQ KRSSVLTQVN QLKTSMQSVL QEWKIYDQLY
DEVNMMTIRF WYCMEHSKPV VLSLETLRCQ VENLQSLQDE AESSEGSWEK LQEVIGKLKG
LCPSVAEIIE EKCQNTHKRW TQVNQAIADQ LQKAQSLLQL WKAYSNAHGE AAARVKQQEA
KFQQLANISM SGNNLAEILP PALQDIKELQ HDVQKTKEAF LQNSSVLDRL PQPAESSTHM
LLPGPLHSLQ RAAYLEKMLL VKANEFEFVL SQFKDFGVRL ESLKGLIMQE EENLDRLHQQ
EKENPDSFLN HVLALTAQSP DIEHLNEVSL KLPLSDVAVK TLQNMNRQWI RATATALERC
SELQGIGLNE KFLYCCEKWI QLLEKIEEAL KVDVANSLPE LLEQQKTYEM LEAEVSINQT
IADSYVTQSL QLLDTTEIEN RPEFITEFSK LTDRWQNAVQ GVRQRKGDVD GLVRQWQDFT
TSVENLFRFL TDTSHLLSAV KGQERFSLYQ TRSLIHELKN KEIHFQRRRT TYALTLEAGE
KLLLTTDLKT KESVGRRISQ LQDSWKDMEP QLAEMIKQFQ STVETWDQCE KKIKELKSRL
QVLKAQSEDP LPELHEDLHN EKELIKELEQ SLASWTQNLK ELQTMKADLT RHVLVEDVMV
LKEQIEHLHR QWEDLCLRVA IRKQEIEDRL NTWVVFNEKN KELCAWLVQM ENKVLQTADI
SIEEMIEKLQ KDCMEEINLF SENKLQLKQM GDQLIKASNK SRAAEIDDKL NKINDRWQHL
FDVIGSRVKK LKETFAFIQQ LDKNMSNLRT WLARIESELS KPVVYDVCDD QEIQKRLAEQ
QDLQRDIEQH SAGVESVFNI CDVLLHDSDA CANETECDSI QQTTRSLDRR WRNICAMSME
RRMKIEETWR LWQKFLDDYS RFEDWLKSAE RTAACPNSSE VLYTSAKEEL KRFEAFQRQI
HERLTQLELI NKQYRRLARE NRTDTASRLK QMVHEGNQRW DNLQRRVTAV LRRLRHFTNQ
REEFEGTRES ILVWLTEMDL QLTNVEHFSE SDADDKMRQL NGFQQEITLN TNKIDQLIVF
GEQLIQKSEP LDAVLIEDEL EELHRYCQEV FGRVSRFHRR LTSCTPGLED EKEASENETD
MEDPREIQTD SWRKRGESEE PSSPQSLCHL VAPGHERSGC ETPVSVDSIP LEWDHTGDVG
GSSSHEEDEE GPYYSALSDV EIPENPEAYL KMTTKTLKAS SGKSISDGHS WHVPDSPSCP
EHHYKQMEGD RNVPPVPPAS STPYKPPYGK LLLPPGTDGG KEGPRVLNGS PQQEDGGLAG
ITEQQSGAFD RWEMIQAQEL HNKLKIKQNL QQLNSDISAI TTWLKKTEAE LEMLKMAKPP
SDIQEIELRV KRLQEILKAF DTYKALVVSV NVSSKEFLQT ESPESTELQS RLRQLSLLWE
AAQGAVDSWR GGLRQSLMQC QDFHQLSQNL LLWLASAENR RQKAHVTDPK ADPRALLECR
RELMQLEKEL VERQPQVDML QEISNSLLIK GHGEDYIEAE EKVHVIEKKL KQLREQVSQD
LMALQGTQNP APPLPSFDEV DSGDQPPATS VPAPRAKVSI TEMRETWDSR SPLAISGHTR
PQRSFLSRVI RAALPLQLLL LLLLLLACLL PSSEEDYSCT QANNFARSFY PMLRYTNGPP
PT
//
