ID A0A2R9A833_PANPA Unreviewed; 303 AA.
AC A0A2R9A833;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Kazal type serine peptidase inhibitor domain 1 {ECO:0000313|Ensembl:ENSPPAP00000013419.1};
GN Name=KAZALD1 {ECO:0000313|Ensembl:ENSPPAP00000013419.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000013419.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000013419.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000013419.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AJFE02089714; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008949067.1; XM_008950819.1.
DR AlphaFoldDB; A0A2R9A833; -.
DR Ensembl; ENSPPAT00000036091.1; ENSPPAP00000013419.1; ENSPPAG00000029890.1.
DR GeneID; 100973586; -.
DR KEGG; pps:100973586; -.
DR CTD; 81621; -.
DR GeneTree; ENSGT00530000063555; -.
DR OMA; TWNITGQ; -.
DR OrthoDB; 3019991at2759; -.
DR Proteomes; UP000240080; Chromosome 10.
DR Bgee; ENSPPAG00000029890; Expressed in heart and 3 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005614; C:interstitial matrix; IEA:Ensembl.
DR GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR GO; GO:0001558; P:regulation of cell growth; IEA:InterPro.
DR CDD; cd00104; KAZAL_FS; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 4.10.40.20; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR011390; IGFBP_rP_mac25.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR PANTHER; PTHR14186; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR14186:SF21; KAZAL-TYPE SERINE PROTEASE INHIBITOR DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR PIRSF; PIRSF018239; IGFBP_rP_mac25; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00280; KAZAL; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..303
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015317128"
FT DOMAIN 48..128
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 119..169
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 171..268
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 303 AA; 32831 MW; 2AA619BB89CEB25A CRC64;
MSPPPPAAAL ALPVLLLLLV VLTPPPTGAR PSPGPDYLRR GWLRLLAEGE GCAPCRPEEC
AAPRGCLAGW VRDACGCCWE CANLEGQLCD LDPSAHFYGH CGEQLECRLD TGDDLSRGEV
PEPLCACRSQ SPLCGSDGHT YSQICRLQEA ARARPDANLT VAHPGPCESG PQIVSHPYDT
WNVTGQDVIF GCEVFAYPMA SIEWRKDGLD IQLPGDDPHI SVQFRGGPQR FEVTGWLQIQ
AVRPSDEGTY RCLARNALGQ VEAPASLTVL TPDQLNATGI PQLRSLNLVP EEEAESEEND
DYY
//
