ID A0A2R9A9T1_PANPA Unreviewed; 617 AA.
AC A0A2R9A9T1;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 4 {ECO:0000313|Ensembl:ENSPPAP00000013646.1};
GN Name=ENTPD4 {ECO:0000313|Ensembl:ENSPPAP00000013646.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000013646.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000013646.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000013646.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR EMBL; AJFE02083108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02083109; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02083110; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9A9T1; -.
DR STRING; 9597.ENSPPAP00000013646; -.
DR Ensembl; ENSPPAT00000036319.1; ENSPPAP00000013646.1; ENSPPAG00000029950.1.
DR GeneTree; ENSGT01100000263540; -.
DR Proteomes; UP000240080; Chromosome 8.
DR Bgee; ENSPPAG00000029950; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0000421; C:autophagosome membrane; IEA:Ensembl.
DR GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0036384; F:CDP phosphatase activity; IEA:Ensembl.
DR GO; GO:0043273; F:CTPase activity; IEA:Ensembl.
DR GO; GO:0004382; F:GDP phosphatase activity; IEA:Ensembl.
DR GO; GO:0045134; F:UDP phosphatase activity; IEA:Ensembl.
DR GO; GO:0046036; P:CTP metabolic process; IEA:Ensembl.
DR GO; GO:0046712; P:GDP catabolic process; IEA:Ensembl.
DR GO; GO:0034656; P:nucleobase-containing small molecule catabolic process; IEA:Ensembl.
DR GO; GO:0006256; P:UDP catabolic process; IEA:Ensembl.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF29; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 4; 1.
DR Pfam; PF01150; GDA1_CD39; 1.
DR PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Hydrolase {ECO:0000256|RuleBase:RU003833};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 566..584
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 223
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 275..279
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 617 AA; 70316 MW; E96610B8A101F462 CRC64;
MGNEIGISCL FPASWHFSIS PVGCPRILNT NLRQIMVISV LAAAVSLLYF SVVIIRNKYG
RLTRDKKFQR YLARVTDIEA TDTNNPSVNY GIVVDCGSSG SRVFVYCWPR HNGNPRDLLD
IRQMRDKNRK PVVMKIKPGI SEFATSPEKV SDYISPLLNF AAEHVPRAKH KETPLYILCT
AGMRILPESQ QKAILEDLLT DIPVHFDFLF SDSHAEVISG KQEGVYAWIG INFVLGRFEH
IEDDDEAVVE VNIPGSESSE AIVRKRTAGI LDMGGVSTQI AYEVPKTVSF ASSQQEEVAK
NLLAEFNLGC DVHQTEHVYR VYVATFLGFG GNAARQRYED RIFANTIQKN RLLGKQTGLT
PDMPYLDPCL PLDIKDEIQQ NGQTIYLRGT GDFDLCRETI QPFMNKTNET QTSLNGVYQP
PIHFQNSEFY GFSEFYYCTE DVLRIGGDYN AAKFTKAAKD YCATKWSILR ERFDRGLYAS
HADLHRLKYQ CFKSAWMFEV FHRGFSFPVN YKSLKTALQV YDKEVQWTLG AILYRTRFLP
LRDIQQEAFR ASHTHWRGVS FVYNHYLFSG CFLVVLLAIL LYLLRLRRIH RRTPRSSSAA
ALWMEEGLPA QNAPGTL
//
