ID A0A2R9ACQ8_PANPA Unreviewed; 1024 AA.
AC A0A2R9ACQ8;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Integrin subunit alpha 10 {ECO:0000313|Ensembl:ENSPPAP00000015060.1};
GN Name=ITGA10 {ECO:0000313|Ensembl:ENSPPAP00000015060.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000015060.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000015060.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000015060.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; AJFE02016903; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02016904; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9ACQ8; -.
DR Ensembl; ENSPPAT00000037748.1; ENSPPAP00000015060.1; ENSPPAG00000030681.1.
DR GeneTree; ENSGT00940000158423; -.
DR OMA; SRNITRY; -.
DR Proteomes; UP000240080; Chromosome 1.
DR Bgee; ENSPPAG00000030681; Expressed in cerebellum and 5 other cell types or tissues.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF26; INTEGRIN ALPHA-10; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 4.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 3.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 22..1024
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5015213065"
FT TRANSMEM 976..1002
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT DOMAIN 24..207
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 329..391
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 392..450
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 454..514
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1024 AA; 112629 MW; 771123F53D19C5EA CRC64;
MELPFVTHLF LPLVFLTGCP TYMDVVIVLD GSNSIYPWSE VQTFLRRLVG KLFIDPEQIQ
VGLVQYGESP VHEWSLGDFR TKEEVVRAAK NLSRREGRET KTAQAIMVAC TEGFSQSHGG
RPEAARLLVV VTDGESHDGE ELPAALKACE AGRVTRYGIA VLGHYLRRQR DPSSFLREIR
TIASDPDERF FFNVTDEAAL TDIVDALGDR IFGLEGSHAE NESSFGLEMS QIGFSTHRLK
DGILFGMVGA YDWGGSVLWL EGGHRLFPPR MALEDEFPPA LQNHAAYLGY SVSSMLLRRG
RRLFLSGAPR FRHRGKVIAF QLKKDGAVRV AQSLQGEQIG SYFGSELCPL DTDRDGTTDV
LLVAAPMFLG PQNKETGRVY VYLVGQQSLL TLQGTLQPEP PQDARFGFAM GALPDLNQDG
FADVAVGAPL EDGHQGALYL YHGTQSGVRP HPAQRIAAAS MPHALSYFGR SVDGRLDLDG
DDLVDVAVGA QGAAILLSSR PIVHLTPSLE VTPQAISVVQ RDCRRRGQEA VCLTAALCFQ
VTSRTPGRWD HQFYMRFTAS LDEWTAGARA AFDGSGQRLS PRRLRLSVGN VTCEQLHFHV
LDTSDYLRPV ALTVTFALDN TTKPGPVLNE GSPTSIQKLV PFSKDCGPDN ECVTDLVLQV
NMDIRGSRKA PFVVRGGRRK VLVSTTLENR KENAYNTSLS LIFSRNLHLA SLTPQRESPI
KVECAAPSAH ARLCSVGHPV FQTGAKVTFL LEFEFSCSSL LSQVFVKLTA SSDSLERNGT
LQDNTAQTSA YIQYEPHLLF ASESTLHRYE VHPYGTLPVG PGPEFKTTLR VQNLGCYVVS
GLIISALLPA VAHGGNYFLS LSQVITNNAS CIVQNLTEPP GPSVHPEELQ HTNRLNGSNT
QCQVVRCHLG QLAKGIEVSV GLLRLVHNEF FRRAKFKSLT VVSTFELGTE EGSVLQLTEA
SRWSESLLEV VQTRPILISL WILIGSVLGG LLLLALLVFC LWKLGFFAHK KIPEEEKREE
KLEQ
//
