ID A0A2R9AD78_PANPA Unreviewed; 1232 AA.
AC A0A2R9AD78;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Cyclin G associated kinase {ECO:0000313|Ensembl:ENSPPAP00000015259.1};
GN Name=GAK {ECO:0000313|Ensembl:ENSPPAP00000015259.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000015259.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000015259.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000015259.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr
CC protein kinase family. PKC subfamily. {ECO:0000256|ARBA:ARBA00005490}.
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DR EMBL; AJFE02035447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02035448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02035449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9AD78; -.
DR Ensembl; ENSPPAT00000037949.1; ENSPPAP00000015259.1; ENSPPAG00000030635.1.
DR GeneTree; ENSGT00940000159527; -.
DR OMA; HYKNTNL; -.
DR Proteomes; UP000240080; Chromosome 4.
DR Bgee; ENSPPAG00000030635; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd06257; DnaJ; 1.
DR CDD; cd14564; PTP_GAK; 1.
DR Gene3D; 2.60.40.1110; -; 1.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR014020; Tensin_C2-dom.
DR InterPro; IPR029023; Tensin_phosphatase.
DR PANTHER; PTHR22967:SF105; CYCLIN G ASSOCIATED KINASE; 1.
DR PANTHER; PTHR22967; SERINE/THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF10409; PTEN_C2; 1.
DR SMART; SM00271; DnaJ; 1.
DR SMART; SM01326; PTEN_C2; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51182; C2_TENSIN; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS51181; PPASE_TENSIN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT DOMAIN 1..235
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 320..487
FT /note="Phosphatase tensin-type"
FT /evidence="ECO:0000259|PROSITE:PS51181"
FT DOMAIN 493..631
FT /note="C2 tensin-type"
FT /evidence="ECO:0000259|PROSITE:PS51182"
FT DOMAIN 1168..1232
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
FT REGION 630..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 722..956
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 968..1071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1085..1120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..743
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..917
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 985..1001
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1049
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1051..1065
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1101..1115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1232 AA; 134415 MW; 18AFA82632644C61 CRC64;
MSLLQSALDF LAGPGSLGGA SGRDQSDFVG QTVELGELRL RVRRVLAEGQ LVEFLKKMES
RGPLSCDTVL KIFYQTCRAV QHMHRQKPPI IHRDLKVENL LLSNQGTIKL CDFGSATTIS
HYPDYSWSAQ RRALVEEEIT RNTTPMYRTP EIIDLYSNFP IGEKQDIWAL GCILYLLCFR
QHPFEDGAKL RIVNGKYSIP PHDTQYTVFH SLIRAMLQVN PEERLSIAEV VHQLQEIAAA
RNVNPKSPIT ELLEQNGGYG SATLSRGPPP PVGPAGSGYS GGLALAEYDQ PYGGFLDILR
GGTERLFTNL KDTSSKVIQS VANYAKGDLD ISYITSRIAV MSFPAEGVES ALKNNIEDVR
LFLDSKHPGH YAVYNLSPRT YRPSRFHNRV SECGWAARRA PHLHTLYNIC RNMHAWLRQD
HKNVCVVHCM DGRAASAVAV CSFLCFCRLF STAEAAVYMF SMKRCPPGIW PSHKRYIEYM
CDMVAEEPIT PHSKPILVRA VVMTPVPLFS KQRSGCRPFC EVYVGDERVA STSQEYDKMR
DFKIEDGKAV IPLGVTVQGD VLIVIYHARS TLGGRLQAKM ASMKMFQIQF HTGFVPRNAT
TVKFAKYDLD ACDIQEKYPD LFQVNLEVEV EPRDRPSREA PPWENSSMRG LNPKILFSSR
EEQQDILSKF GKPELPRQPG STAQYDAGAG SPEAEPTDSD SPPSSSADAS HFLHTLDWQE
EKEAETGAEN ASPKESESAL MEDRDESEVS DDGGSPISSE GQEPRADPEP PGLAAGPVQQ
DLVFEVETPA VLPEPVPQED GVDLLGLHSE VGAGPAVPPQ ACKAPSSNTD LLSCLLGPPE
AASQGPPEDL LSEDPLLLAS PAPPLSVQST PRGGPPAAAD PFGPLLPSSG NNSQPCSNPD
LFGEFLNSDS VTVPPSFPSA HSAPPPSCSA DFLHLGDLPG EPSKMTASSS NPDLLGGWAA
WTETAASAVA PTPATEGPLF SSGGQPAPCG SQASWTKSQN PDPFADLGDL SSGLQGSPAG
FPPGGFIPKT ATTPKGSSSW QTSRPPAQGA SWPPQAKPPP KACTQPRPNY ASNFSVIGAR
EERGVRAPSF AQKPKVSEND FEDLLSNQGF SSRSDKKGPK TIAEMRKQDL AKDTDPLKLK
LLDWIEGKER NIRALLSTLH TVLWDGESRW TPVGMADLVA PEQVKKHYRR AVLAVHPDKA
AGQPYEQHAK MIFMELNDAW SEFENQGSRP LF
//