ID A0A2R9AE15_PANPA Unreviewed; 874 AA.
AC A0A2R9AE15;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Active breakpoint cluster region-related protein {ECO:0000256|ARBA:ARBA00019427};
GN Name=ABR {ECO:0000313|Ensembl:ENSPPAP00000013662.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000013662.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000013662.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000013662.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendritic spine
CC {ECO:0000256|ARBA:ARBA00004552}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
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DR EMBL; AJFE02057300; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02057301; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02057302; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02057303; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02057304; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02057305; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02057306; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02057307; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02057308; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02057309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9AE15; -.
DR STRING; 9597.ENSPPAP00000013662; -.
DR Ensembl; ENSPPAT00000036335.1; ENSPPAP00000013662.1; ENSPPAG00000029873.1.
DR GeneTree; ENSGT00940000153491; -.
DR Proteomes; UP000240080; Chromosome 17.
DR Bgee; ENSPPAG00000029873; Expressed in prefrontal cortex and 6 other cell types or tissues.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08686; C2_ABR; 1.
DR CDD; cd13366; PH_ABR; 1.
DR CDD; cd04387; RhoGAP_Bcr; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR037769; Abr/Bcr.
DR InterPro; IPR037865; ABR_PH.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23182:SF5; ACTIVE BREAKPOINT CLUSTER REGION-RELATED PROTEIN; 1.
DR PANTHER; PTHR23182; BREAKPOINT CLUSTER REGION PROTEIN BCR; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT DOMAIN 103..299
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 316..474
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 499..628
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 662..860
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 39..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 874 AA; 98965 MW; DD83830B3D88EB1D CRC64;
MAAGGRRRRP LRYQSLAALV EDSQWPFLFL VSDFSYGTDE YDGEGNEEQK GPPEGSETMP
YIDESPTMSP QLSARSQGGG DGVSPTPPEG LAPGVEAGKG LEMRKLVLSG FLASEEIYIN
QLEALLLPMK PLKATATTSQ PVLTIQQIET IFYKIQDIYE IHKEFYDNLC PKVQQWDSQV
TMGHLFQKLA SQLGVYKAFV DNYKVALETA EKCSQSNNQF QKISELVSGV LGCPRPSSSS
SFSLSPPTAL LYKPIDRVTR STLVLHDLLK HTPVDHPDYP LLQDALRISQ NFLSSINEDI
DPRRTAVTTP KGETRQLVKD GFLVEVSESS RKLRHVFLFT DVLLCAKLKK TSAGKHQQYD
CKWYIPLADL VFPSPEESEA SPQVHPFPDH ELEDMKMKIS ALKSEIQKEK ANKGQSRAIE
RLKKKMFENE FLLLLNSPTI PFRIHNRNGK SYLFLLSSDY ERSEWREAIQ KLQKKDLQAF
VLSSVELQVL TGSCFKLRTV HNIPVTSNKD DDESPGLYGF LHVIVHSAKG FKQSANLYCT
LEVDSFGYFV SKAKTRVFRD TAEPKWDEEF EIELEGSQSL RILCYEKCYD KTKVNKDNNE
IVDKIMGKGQ IQLDPQTVET KNWHTDVIEM NGIKVEFSMK FTSRDMSLKR TPSKKQTGVF
GVKISVVTKR ERSKVPYIVR QCVEEVEKRG IEEVGIYRIS GVATDIQALK AVFDANNKDI
LLMLSDMDIN AIAGTLKLYF RELPEPLLTD RLYPAFMEGI ALSDPAAKEN CMMHLLRSLP
DPNLITFLFL LEHLKRVAEK EPINKMSLHN LATVFGPTLL RPSEVESKAH LTSAADIWSH
DVMAQVQVLL YYLQHPPISF AELKRNTLYF STDV
//
