ID A0A2R9AHJ6_PANPA Unreviewed; 881 AA.
AC A0A2R9AHJ6;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=RAS p21 protein activator 1 {ECO:0000313|Ensembl:ENSPPAP00000016822.1};
GN Name=RASA1 {ECO:0000313|Ensembl:ENSPPAP00000016822.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000016822.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000016822.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000016822.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AJFE02079536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02079537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02079538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02079539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9AHJ6; -.
DR SMR; A0A2R9AHJ6; -.
DR Ensembl; ENSPPAT00000039521.1; ENSPPAP00000016822.1; ENSPPAG00000031210.1.
DR GeneTree; ENSGT00940000155846; -.
DR Proteomes; UP000240080; Chromosome 5.
DR Bgee; ENSPPAG00000031210; Expressed in placenta and 6 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd08400; C2_Ras_p21A1; 1.
DR CDD; cd05391; RasGAP_p120GAP; 1.
DR CDD; cd10354; SH2_Cterm_RasGAP; 1.
DR CDD; cd11788; SH3_RasGAP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR035842; RasGAP_C_SH2.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR035652; RasGAP_SH3.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10194:SF146; RAS GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF00017; SH2; 2.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00252; SH2; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS50001; SH2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 15..106
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 113..175
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 185..275
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 308..411
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 411..524
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 582..776
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
SQ SEQUENCE 881 AA; 101790 MW; E6000EFADBBB469E CRC64;
MCLVKSWFLS IRSRWYHGKL DRTIAEERLR QAGKSGSYLI RESDRRPGSF VLSFLSQMNV
VNHFRIIAMC GDYYIGGRRF SSLSDLIGYY SHVSCLLKGE KLLYPVAPPE PVEDRRRVRA
ILPYTKVPDT DEISFLKGDM FIVHNELEDG WMWVTNLRTD EQGLIVEDLV EEVGREEDPH
EGKIWFHGKI SKQEAYNLLM TVGQVCSFLV RPSDNTPGDY SLYFRTNENI QRFKICPTPN
NQFMMGGRYY NSIGDIIDHY RKEQIVEGYY LKEPVPMQDQ EQVLNDTVDG KEIYNTIRRK
TKDAFYKNIV KKGYLLKKGK GKRWKNLYFI LEGSDAQLIY FESEKRATKP KGLIDLSVCS
VYVVHDSLFG RPNCFQIVVQ HFSEEHYIFY FAGETPEQAE DWMKGLQAFC NLRKSSPGTS
NKRLRQVSSL VLHIEEAHKL PVKHFTNPYC NIYLNSVQVA KTHAREGQNP VWSEEFVFDD
LPPDINRFEI TLSNKTKKSK DPDILFMRCQ LSRLQKGHAT DEWFLLSSHI PLKGIEPGSL
RVRARYSMEK IMPEEEYSEF KELILQKELH VVYALSHVCG QDRTLLASIL LRIFLHEKLE
SLLLCTLNDR EISMEDEATT LFRATTLAST LMEQYMKATA TQFVHHALKD SILKIMESKQ
SCELSPSKLE KNEDVNTNLT HLLNILSELV EKIFMASEIL PPTLRYIYGC LQKSVQHKWP
TNTTMRTRVV SGFVFLRLIC PAILNPRMFN IISDSPSPIA ARTLILVAKS VQNLANLVEF
GAKEPYMEGV NPFIKSNKHR MIMFLDELGN VPELPDTTEH SRTDLSRDLA ALHEICVAHS
DELRTLSNER GAQQHVLKKL LAITELLQQK QNQYTKTNDV R
//
