ID A0A2R9AI30_PANPA Unreviewed; 3062 AA.
AC A0A2R9AI30;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Protein prune homolog 2 {ECO:0000256|ARBA:ARBA00039860};
DE AltName: Full=BNIP2 motif-containing molecule at the C-terminal region 1 {ECO:0000256|ARBA:ARBA00042084};
GN Name=PRUNE2 {ECO:0000313|Ensembl:ENSPPAP00000014872.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000014872.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000014872.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000014872.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PPase class C family. Prune subfamily.
CC {ECO:0000256|ARBA:ARBA00010331}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJFE02036128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02036129; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02036130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02036131; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02036132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02036133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02036134; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008962117.1; XM_008963869.2.
DR Ensembl; ENSPPAT00000037560.1; ENSPPAP00000014872.1; ENSPPAG00000030555.1.
DR GeneTree; ENSGT00940000154422; -.
DR OrthoDB; 5402707at2759; -.
DR Proteomes; UP000240080; Chromosome 9.
DR Bgee; ENSPPAG00000030555; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016462; F:pyrophosphatase activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 3.10.310.20; DHHA2 domain; 1.
DR Gene3D; 3.90.1640.10; inorganic pyrophosphatase (n-terminal core); 1.
DR InterPro; IPR022181; Bcl2-/adenovirus-E1B.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR038763; DHH_sf.
DR InterPro; IPR004097; DHHA2.
DR InterPro; IPR038222; DHHA2_dom_sf.
DR PANTHER; PTHR12112; BNIP - RELATED; 1.
DR PANTHER; PTHR12112:SF11; PROTEIN PRUNE HOMOLOG 2; 1.
DR Pfam; PF12496; BNIP2; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF02833; DHHA2; 1.
DR SMART; SM01131; DHHA2; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF64182; DHH phosphoesterases; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT DOMAIN 2895..3059
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT REGION 433..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 672..795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 847..909
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 949..1083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1192..1211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1231..1371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1413..1591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1626..1699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1735..1814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2023..2046
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2087..2147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2173..2215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2240..2263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2512..2542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2589..2666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2685..2710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2814..2833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2841..2875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..582
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 608..643
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 682..696
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..738
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 884..898
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 949..979
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 980..1004
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1005..1028
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1047..1068
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1069..1083
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1234..1279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1318..1345
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1353..1370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1439..1453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1500..1591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1629..1668
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1676..1691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1753..1777
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1792..1814
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2023..2045
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2107..2123
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2177..2207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2240..2259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2589..2604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2615..2633
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2853..2867
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3062 AA; 337454 MW; 7023EB85CA9C78FE CRC64;
MEEFLQRAKS KLNRSKRLEK VHVVIGPKSC DLDSLISTFT YAYFLDKVSP PGVLCLPVLN
IPRTEFNYFT ETRFILEELN ISESFHIFRD EINLHQLNDE GKLSITLVGS SVLASEDKTL
ESAVVKVINP VEQSDANVEF RESSSSLVLK EILQEAPELI TEQLAHRLRG SILFKWMTME
SEKISEKQEE ILSILEEKFP NLPPREDIIN VLQETQFSAQ GLSIEQTMLK DLKELSDGEI
KVAISTVSMN LENCLFHSNI TSDLKAFTDK FGFDVLILFS SYLSEEQQPR RQIAVYSENM
ELCSQICCEL EECQNPCLEL EPFDCGCDEI LVYQQEDPSV TCDQVVLVVK EVINRRCPEM
VSNSRTSSTE AVAGSAPLSQ GSSGIMELYG SDIEPQPSSV NFIENPPDLN DSNQAQVDAN
VDLVSPDSGL ATIRSSRSSK ESSVFLSDDS PVGEGAGPHH TLLPGLDSYS PIPEGAVAEE
HAWSGEHGEH FDLFSFDPAP MASGQSQQSS HSADYSPADD FFPNSDLSEG QLPAGPEGLD
GMGTNMSNYS SSSLLSGAGK DSLVEHDEEF VQRQDSPRDN SERNLSLTDF VGDESPSPER
LKNTGKRIPP TPMNSLVESS PSTEEPASLY TEDMTQKATD TGHMGPPQTH ARCSSWWGGL
EIDSKNIADA WSSSEQESVF QSPESWKKHK PSSIDRRASD SVFQPKSLEF TKSGPWESEF
GQPELGSNDI QDKNEESLPF QNLPMEKSPL PNTSPQGTNH LIEDFASLWH SGHSPTAMPE
PWGNPTDDGE PAAVAPFPAW SAFGKEDHAE ALKNTWNLHP TSSKTPSVRD PNEWAMAKSG
FAFSSSELLD NSPSEINNEA APEIWGKKNN DSRDHIFAPG NPSSDLDHTW TNSKPPKEDQ
NGLVDPKTRG KVYEKVDSWN LFEENMKKGG SDVLVPWEDS FLSYKCSDYS ASNLGEDSVP
SPLDTNYSTS DSYTSPTFAG DEKETEHKPF AKEEGFESKD GNSTAEETDI PPQSLQQSSR
NRISSGPGNL DMWASPHTGN SSEINTTHDL DENELETEHT DGKNISMEDD VGESSQSSYD
DPSMMQLYNE TNRQLTLLHS STNSRQTASD SLDLWNRVIL EDTQSTATIS DMDNDLDWDD
CSGGVAIPSD GQTEGYMAEG SEPETRFTVR QLEPWGLEYQ EANQVDWELP ASDEHTKDSA
PSEHHTLNEK SGQLIANSIW DSVMRDKDMS SFMLPGSSHI TDSEQSELPP EIPSHSANVK
DTHSPDAPAA SGTSESEALI SHLDKQDTER ETLQSDAASL ATRLENPGYF AHPDPWKGHG
DAQSESEKEA QGATDRGHLD EEEVIASGVE NASGISEKGQ SDQELSSLVA SEHQEICIKS
GKISSLAVTF SPQTEEPEEV LEYEEGSYDL DSRDVQTGMS ADNLQPKDTH EKHLMSQRNS
GETTETSDGM NFTKYVSVPE KDLEKTEECN FLEPENVGGG PPHRVPRSLD FGDVPIDSDV
HVSSTRSEIT KNLDIKGSEN SLPGAGSSGN FDRDTISSEY THSSASSPEL NDSSVALSSW
GQQPSSGYQE ENQGNWSEQN HQESELITTD GQVEIVTKMK DLEKNRINEF EKSFDRKTPT
FLEIWNDSVD GDSFSSLSSP ETGKYSEHSG THQESNLIAS YQEKNEHDIS ATVQPEDARV
ISTSSGSDDD SVSGEESIEE EIQVANCHFA EDESRAWDSL NESNKFLVTA DPKSENIYDY
LDSSEPAESE NKSDSFCDNQ QSSPDPWTFS PLTETEMQIT AVEKEKRSSP ETGTTGDVAW
QISPKASFPK NEDNSQLEML GFSADSTEWW KASPQEGRLI ESPFERELSD SSGLLEINSS
VYQNASPLGV PVQGDFEPVE THYTNPFSDN HQSPFLEGNG ENSHEQLWNI QPRQPDPDAD
KFSQLVKLDQ IKGKDSREQT FVSAAGDELT PETPTQEQCQ DTMLSVCDHP DAAFTHAEEN
SCVTSNVSTN EGQETNQWEQ EKSYLGEMTN SSIATENFPA VSSPTQLITK PGSEWDGSTP
SEDSRGTFVP DILHGNFQEG GQLASAAPDL WIDAKKPFSL KADGENPDIL THCEHDSNSQ
ASDSPDICHD SEAKQETEKH LSACMGPEVE SSELCLTEPE IDEEPIYEPG REFVPSNAEL
DSENVTLLPP IGYQADIKGS SQPTSHKGSP EPSEINGDNS TGLQVSEKGA SPDMAPILEP
VDRRIPRIEN VATSIFVTHQ EPTPEGDSSW ISDSFSPESQ PGARALFDGD PHLSTENPAL
VPDALLASDT CLDISEAAFD HSFSDASGLN TSTGTIDDMS KLTLSEGHPE TPVDGDLGKQ
DICSSEASWG DFEYDVMGQN IDEDLLREPE HFLYGGDPPL EEDSLKQSLA PYTPPFDLSY
LTEPAQSAET MEEAGSPEDE SLGCRAAEIV LSALPDRRSE GNQAETKNRL PGSQLAVLHI
HEDPESVYLP VGAGSNILSP SNVDWEVETD NSDLPAGGDI GPPNGASKEI TELEEEKTIP
TKEPEQIKSE YKEERCTEKN EDRHALHMDY ILVNREENSH SKPETCEERE SIAELELYVG
SKETGLQGTQ LASFPDTCQP ASLNERKGLS AEKMSSKGDT RSSFESPAQD QSWMFLGHSE
VGDPSLDARD SGPGWSGKTV EPFSELSLGE GPQLQILEEM KPLESLALEE ASGPVSQSQK
SKSRGRAGPD AVTLQAVTHD NEWEMLSPQP VQKNMIPGTE MEEETEFLEL GTRISRPNGL
LSEDVGMDIP FEEGVLSPSA ADMRPEPPNS LDLNDTHPRR IKLTAPNINL SLDQSEGSIL
SDDNLDSPDE IDINVDELDT PDEADSFEYT GHDPTANKDS GQESESIPEY TAEEEREDNR
LWRTVVIGEQ EQRIDMKVIE PYRRVISHGG DSGYYGDGLN AIIVFAACFL PDSSRADYHY
VMENLFLYVI STLELMVAED YMIVYLNGAT PRRRMPGLGW MKKCYQMIDR RLRKNLKSFI
IVHPSWFIRT ILAVTRPFIS SKFSSKIKYV NSLSELSGLI PMDCIHIPES IINIDLKLKE
KP
//
