ID A0A2R9AI37_PANPA Unreviewed; 279 AA.
AC A0A2R9AI37;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Caspase 8 {ECO:0000313|Ensembl:ENSPPAP00000015218.1};
GN Name=CASP8 {ECO:0000313|Ensembl:ENSPPAP00000015218.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000015218.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000015218.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AJFE02071110; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9AI37; -.
DR Ensembl; ENSPPAT00000037907.1; ENSPPAP00000015218.1; ENSPPAG00000030711.1.
DR GeneTree; ENSGT00940000160319; -.
DR Proteomes; UP000240080; Unplaced.
DR Bgee; ENSPPAG00000030711; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08333; DED_Caspase_8_r1; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR InterPro; IPR033170; Caspase-8_DED1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001875; DED_dom.
DR InterPro; IPR001309; Pept_C14_p20.
DR PANTHER; PTHR48169:SF3; CASP8 AND FADD-LIKE APOPTOSIS REGULATOR A-RELATED; 1.
DR PANTHER; PTHR48169; DED DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01335; DED; 2.
DR SMART; SM00031; DED; 2.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR PROSITE; PS50208; CASPASE_P20; 1.
DR PROSITE; PS50168; DED; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT DOMAIN 2..80
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 100..177
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 217..252
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
SQ SEQUENCE 279 AA; 32616 MW; 5B1544421F728FEF CRC64;
MDFSRNLYDI GEQLDSEDLA SLKFLSLDYI PQRKQEPIKD ALMLFQRLQE KRMLEESNLS
FLKELLFRIN RLDLLITYLN TRKEEMEREL QTPGRAQISA YRVMLYQISE EVSRSELRSF
KFLLQEEISK CKLDDDMNLL DIFIEMEKRV ILGEGKLDIL KRVCAQINRS LLKIINDYEE
FSKGEELCGV MTISDSPREQ DSESQTLDKV YQMKSKPRGY CLIINNHNFA KAREKVPKLH
SIRDRNGTHL DAGTSHSVAQ AGVQWCDLSS LQPPPPWFK
//
