ID A0A2R9AIA8_PANPA Unreviewed; 1300 AA.
AC A0A2R9AIA8;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Zinc finger protein 532 {ECO:0000313|Ensembl:ENSPPAP00000015308.1};
GN Name=ZNF532 {ECO:0000313|Ensembl:ENSPPAP00000015308.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000015308.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000015308.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000015308.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC {ECO:0000256|ARBA:ARBA00003767}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR EMBL; AJFE02095687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02095688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02095689; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02095690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02095691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9597.ENSPPAP00000015308; -.
DR Ensembl; ENSPPAT00000037998.1; ENSPPAP00000015308.1; ENSPPAG00000030764.1.
DR GeneTree; ENSGT00940000154437; -.
DR OMA; HIKQNVH; -.
DR Proteomes; UP000240080; Chromosome 18.
DR Bgee; ENSPPAG00000030764; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 7.
DR InterPro; IPR045914; Zn532-like.
DR InterPro; IPR041697; Znf-C2H2_11.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR47222:SF3; ZINC FINGER PROTEIN 532; 1.
DR PANTHER; PTHR47222; ZINC FINGER PROTEIN 532-RELATED; 1.
DR Pfam; PF16622; zf-C2H2_11; 1.
DR Pfam; PF13912; zf-C2H2_6; 1.
DR SMART; SM00355; ZnF_C2H2; 15.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 5.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 615..633
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 753..783
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 869..897
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 904..931
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 935..963
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1054..1082
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1202..1230
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1263..1285
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 26..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 982..1014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1229..1262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..53
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..245
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 993..1012
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1245..1262
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1300 AA; 141588 MW; 2B23A7F25B6716ED CRC64;
MTMGDMKTPD FDDLLAAFDI PDMVDPKAAI ESGHDDHESH MKQNAHGEDD SHAPSSSDVG
VSVIVKNVRN IDSSEGGEKD GHNPTGNGLH NGFLTASSLD SYSKDGAKSL KGDVPASEVT
LKDSTFSQFS PISSAEEFDD DEKIEVDDPP DKEDVRSSFR SNVLTGSAPQ QDYDKLKALG
GENSSKTGLS TSGNVEKNKV VKRETEANSI NLSVYEPFKV RKAEDKLKES SDKVLENRVL
DGKPSSEKND TSLPTVAPSK TKSSSKLSSC IAAIAALSAK KAASDSCKEP VANSRESSPL
PKEVNDSPRA ADKSPESQNL IDGTKKPSLK QPDSPRSISS ENSSKGSPSS PAGSTPAIPK
VRIKTIKTSS GEIKRTVTRV LPEVDLDSGK KPSEQTASVM ASVTSLLSSP ASAAVLSSPP
RAPLQSAVVT NAVSPAELTP KQVTIKPVAT AFLPVSAVKT AGSQVINLKL ANNTTVKATV
ISAASVQSAS SAIIKAANAI QQQTVVVPAS SLANAKLVPK TVHLANLNLL PQGAQATSEL
RQVLTKPQQQ IKQAIINAAA SQPKKVSRVQ VVSSLQSSVV EAFNKVLSSV NPVPVYIPNL
SPPANAGITL PTRGYKCLEC GDSFALEKSL TQHYDRRSVR IEVTCNHCTK NLVFYNKCSL
LSHARGHKEK GVVMQCSHLI LKPVPADQMI VSPSSNTSTS TSTLQSPVGA GTHTVTKIQS
GITGTVISAP SSTPITPAMP LDEDPSKLCR HSLKCLECNE VFQDETSLAT HFQQAADTSG
QKTCTICQML LPNQCSYASH QRIHQHKSPY TCPECGAICR SVHFQTHVTK NCLHYTRRVG
FRCVHCNVVY SDVAALKSHI QGSHCEVFYK CPICPMAFKS APSTHSHAYT QHPGIKIGEP
KIIYKCSMCD TVFTLQTLLY RHFDQHIENQ KVSVFKCPDC SLLYAQKQLM MDHIKSMHGT
LKSIEGPPNL GINLPLSIKP ATQNSANQNK EDTKSMNGKE KLEKKSPSPV KKSVETKKVA
SPGWTCWECD CLFMQRDVYI SHVRKEHGKQ MKKHPCRQCD KSFSSSHSLC RHNRIKHKGI
RKVYACSHCP DSRRTFTKRL MLEKHVQLMH GIKDPDLKEM TDATNEEETE IKEDTKVPSP
KRKLEEPVLE FRPPRGAITQ PLKKLKINVF KVHKCAVCGF TTENLLQFHE HIPQHKSDGS
SYQCRECGLC YTSHVSLSRH LFIVHKLKEP QPVSKQNGAG EDNQQENKPS HEDESPDGAV
SDRKCKVCAK TFETEAALNT HMRTHGMAFI KSKRMSSAEK
//
