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Database: UniProt
Entry: A0A2R9AJF5_PANPA
LinkDB: A0A2R9AJF5_PANPA
Original site: A0A2R9AJF5_PANPA 
ID   A0A2R9AJF5_PANPA        Unreviewed;       660 AA.
AC   A0A2R9AJF5;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=THO complex subunit 1 {ECO:0000313|Ensembl:ENSPPAP00000017501.1};
GN   Name=THOC1 {ECO:0000313|Ensembl:ENSPPAP00000017501.1};
OS   Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000017501.1, ECO:0000313|Proteomes:UP000240080};
RN   [1] {ECO:0000313|Ensembl:ENSPPAP00000017501.1, ECO:0000313|Proteomes:UP000240080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22722832; DOI=10.1038/nature11128;
RA   Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA   Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA   Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA   Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA   Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA   Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA   Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA   Paabo S.;
RT   "The bonobo genome compared with the chimpanzee and human genomes.";
RL   Nature 486:527-531(2012).
RN   [2] {ECO:0000313|Ensembl:ENSPPAP00000017501.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   EMBL; AJFE02052181; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A2R9AJF5; -.
DR   STRING; 9597.ENSPPAP00000017501; -.
DR   Ensembl; ENSPPAT00000040208.1; ENSPPAP00000017501.1; ENSPPAG00000031812.1.
DR   GeneTree; ENSGT00390000016232; -.
DR   OMA; VDPAFEW; -.
DR   Proteomes; UP000240080; Chromosome 18.
DR   Bgee; ENSPPAG00000031812; Expressed in placenta and 6 other cell types or tissues.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR   GO; GO:0000445; C:THO complex part of transcription export complex; IEA:Ensembl.
DR   GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR   GO; GO:0006406; P:mRNA export from nucleus; IEA:Ensembl.
DR   GO; GO:2000002; P:negative regulation of DNA damage checkpoint; IEA:Ensembl.
DR   GO; GO:0048297; P:negative regulation of isotype switching to IgA isotypes; IEA:Ensembl.
DR   GO; GO:0032786; P:positive regulation of DNA-templated transcription, elongation; IEA:Ensembl.
DR   GO; GO:0031297; P:replication fork processing; IEA:Ensembl.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   GO; GO:0046784; P:viral mRNA export from host cell nucleus; IEA:Ensembl.
DR   CDD; cd08318; Death_NMPP84; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR021861; THO_THOC1.
DR   PANTHER; PTHR13265; THO COMPLEX SUBUNIT 1; 1.
DR   PANTHER; PTHR13265:SF2; THO COMPLEX SUBUNIT 1; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF11957; efThoc1; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT   DOMAIN          573..656
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
FT   REGION          197..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          536..572
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        544..558
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   660 AA;  75979 MW;  5321BA534A274E27 CRC64;
     AEKMSPTPPL FSLPEARTRF TKSTREALNN KNIKPLLSTF SQVPGSENEK KCTLDQAFRG
     ILEEEIINHS SCENVLAIIS LAIGGVTEGI CTASTPFVLL GDVLDCLPLD QCDTIFTFVE
     KNVATWKSNT FYSAGKNYLL RMCNDLLRRL SKSQNTVFCG RIQLFLARLF PLSEKSGLNL
     QSQFNLENVT VFNTNEQEST LGQKHTEDRE EGMDVEEGEM GDEEAPTTCS IPIDYNLYRK
     FWSLQDYFRN PVQCYEKISW KTFLKYSEEV LAVFKSYKLD DTQASRKKME ELKTGGEHVY
     FAKFLTSEKL MDLQLSDSNF RRHILLQYLI LFQYLKGQVK FKSSNYVLTD EQSLWIEDTT
     KSVYQLLSEN PPDGERFSKM VEHILNTEEN WNSWKNEGCP SFVKERTSDT KPTRIIRKRT
     APEDFLGKGP SKKILMGNEE LTRLWNLCPD NMEACKSETR EYMPTLEEFF EEAIEQADPE
     NMVENEYKAV NNSNYGWRAL RLLARRSPHF FQPTNQQFKS LPEYLENMVI KLAKELPPPS
     EEIKTGEDED EEDNDALLKE NESPDVRQDK PVTGEQIEVF ANKLGEQWKI LAPYLEMKDS
     EIRQIECDSE DMKMRAKQLL VAWQDQEGVH ATPENLINAL NKSGLSDLAE SLTNDNETNS
//
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