ID A0A2R9AJF5_PANPA Unreviewed; 660 AA.
AC A0A2R9AJF5;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=THO complex subunit 1 {ECO:0000313|Ensembl:ENSPPAP00000017501.1};
GN Name=THOC1 {ECO:0000313|Ensembl:ENSPPAP00000017501.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000017501.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000017501.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000017501.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AJFE02052181; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9AJF5; -.
DR STRING; 9597.ENSPPAP00000017501; -.
DR Ensembl; ENSPPAT00000040208.1; ENSPPAP00000017501.1; ENSPPAG00000031812.1.
DR GeneTree; ENSGT00390000016232; -.
DR OMA; VDPAFEW; -.
DR Proteomes; UP000240080; Chromosome 18.
DR Bgee; ENSPPAG00000031812; Expressed in placenta and 6 other cell types or tissues.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0000445; C:THO complex part of transcription export complex; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR GO; GO:0006406; P:mRNA export from nucleus; IEA:Ensembl.
DR GO; GO:2000002; P:negative regulation of DNA damage checkpoint; IEA:Ensembl.
DR GO; GO:0048297; P:negative regulation of isotype switching to IgA isotypes; IEA:Ensembl.
DR GO; GO:0032786; P:positive regulation of DNA-templated transcription, elongation; IEA:Ensembl.
DR GO; GO:0031297; P:replication fork processing; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0046784; P:viral mRNA export from host cell nucleus; IEA:Ensembl.
DR CDD; cd08318; Death_NMPP84; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR021861; THO_THOC1.
DR PANTHER; PTHR13265; THO COMPLEX SUBUNIT 1; 1.
DR PANTHER; PTHR13265:SF2; THO COMPLEX SUBUNIT 1; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF11957; efThoc1; 1.
DR SMART; SM00005; DEATH; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT DOMAIN 573..656
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 197..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 536..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..558
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 660 AA; 75979 MW; 5321BA534A274E27 CRC64;
AEKMSPTPPL FSLPEARTRF TKSTREALNN KNIKPLLSTF SQVPGSENEK KCTLDQAFRG
ILEEEIINHS SCENVLAIIS LAIGGVTEGI CTASTPFVLL GDVLDCLPLD QCDTIFTFVE
KNVATWKSNT FYSAGKNYLL RMCNDLLRRL SKSQNTVFCG RIQLFLARLF PLSEKSGLNL
QSQFNLENVT VFNTNEQEST LGQKHTEDRE EGMDVEEGEM GDEEAPTTCS IPIDYNLYRK
FWSLQDYFRN PVQCYEKISW KTFLKYSEEV LAVFKSYKLD DTQASRKKME ELKTGGEHVY
FAKFLTSEKL MDLQLSDSNF RRHILLQYLI LFQYLKGQVK FKSSNYVLTD EQSLWIEDTT
KSVYQLLSEN PPDGERFSKM VEHILNTEEN WNSWKNEGCP SFVKERTSDT KPTRIIRKRT
APEDFLGKGP SKKILMGNEE LTRLWNLCPD NMEACKSETR EYMPTLEEFF EEAIEQADPE
NMVENEYKAV NNSNYGWRAL RLLARRSPHF FQPTNQQFKS LPEYLENMVI KLAKELPPPS
EEIKTGEDED EEDNDALLKE NESPDVRQDK PVTGEQIEVF ANKLGEQWKI LAPYLEMKDS
EIRQIECDSE DMKMRAKQLL VAWQDQEGVH ATPENLINAL NKSGLSDLAE SLTNDNETNS
//