ID A0A2R9AJQ1_PANPA Unreviewed; 1181 AA.
AC A0A2R9AJQ1;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=NLR family pyrin domain containing 5 {ECO:0000313|Ensembl:ENSPPAP00000017303.1};
GN Name=NLRP5 {ECO:0000313|Ensembl:ENSPPAP00000017303.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000017303.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000017303.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000017303.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR EMBL; AJFE02030596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030597; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030600; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9AJQ1; -.
DR STRING; 9597.ENSPPAP00000017303; -.
DR Ensembl; ENSPPAT00000040005.1; ENSPPAP00000017303.1; ENSPPAG00000031725.1.
DR GeneTree; ENSGT00940000162898; -.
DR Proteomes; UP000240080; Chromosome 19.
DR GO; GO:0060473; C:cortical granule; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0106333; C:subcortical maternal complex; IEA:Ensembl.
DR GO; GO:0015631; F:tubulin binding; IEA:Ensembl.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF7; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 5; 1.
DR Pfam; PF13516; LRR_6; 6.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM00368; LRR_RI; 11.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 2.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT DOMAIN 69..148
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 265..395
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 142..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1181 AA; 132474 MW; 2362577009CBFB8F CRC64;
MKVAGGLELG AVNLLQDPLL SLVTLSTGPT CSILPKNPLF PQNLSSQPCI KMEGDKSLTF
SSYGLQWCLY ELDKEEFQTF KELLKKKSSE STTCSIPQFE IENANVECLA LLLHEYYGAS
LAWATSISIF ENMNLRTLSE KARDDMKRHS PEDPEATTTD QGPSKEKLIL GVSDISDLNN
KHKYVGIHSS FAEISQAMEQ EGATAAETEE QGHGGDTWDY KSHVMTKFAE EQDVRRSFEK
TAADWPEMQT LAGAFNSDQW GFRPRTVVLH GKSGIGKSAL ARRIVLCWAQ GGLYQGMFSY
VFFLPVREMQ RKKESSVTEF ISREWPDSQA PVTEIMSRPE RLLFIIDGFD DLGSVLSSDT
KLCKDWAEKQ PPFILIRSLL RKVLLPESFL IITVRDVGIE KLKSEVVSPR YLLVRGISGE
QRIHLLLERG IGEHQKTQGL RAIMNNRKLF DQCQVPAVGS LICVALQLQD VVGESVAPFN
QTLTGLYAAF VFHQLTPRGV ARRCLNLEER VVLKRFCRMA VEGVWNRKSV FDGDDLMVQG
LGESELRALF HMNILLPDSH CEEHYTFFHL SLQDFCAALY YVLEGLEIEP ALCPLYVEKT
KRSMELKQAG FHIHSLWMKR FLFGLVSEDV RRPLEVLLGC PVPLGVKQKL LHWVSLLGQQ
QKAPGDTLDA FHCLFETQDK EFVRLALNGF QEVWLPINQN LDLIASSFCL QHCPYLRKIR
VDVKGIFPRD ESTEACPVVP LWMRGKTLIE EQWEDFCSVL GTHPHLRQLD LGSSILTERA
MKTLCAKLRH STCKIQTLMF RNAQITPGVQ HLWRILMANR NLRSLNLGGT HLKEEDVRMA
CEALKHPKCL LESLRLDCCG LTHACYLKIS QILTTSPSLK SLSLAGNKVT DQGVTPLSDA
LRVSQCALQK LILEDCGITA TGCQSLASAL VSNRSLTHLC LSNNSLGNEG VNLLCRSMRL
PHCSLQRLNQ CHLDTAGCGF LALALMGNSW LTHLSLSMNP VEDNGVKLLC EVMREPSCHL
QDLELVKCHL TAACCESLSC VISRSRHLKS LDLTDNALGD GGVAALCEGL KQKNSVLTRL
GLKACGLTSD CCEALSLALS CNRHLTSLNL VQNNFSPKGM MKLCSAFACP TSNLQIIGLW
KWQYPVQIRK LLEEVQLLKP QIVIDGSWHS FDEDDRYWWK N
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