ID A0A2R9AKU5_PANPA Unreviewed; 355 AA.
AC A0A2R9AKU5;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Major histocompatibility complex, class I, G {ECO:0000313|Ensembl:ENSPPAP00000016260.1};
GN Name=HLA-G {ECO:0000313|Ensembl:ENSPPAP00000016260.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000016260.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000016260.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000016260.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MHC class I family.
CC {ECO:0000256|RuleBase:RU004439}.
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DR EMBL; AJFE02104378; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9AKU5; -.
DR STRING; 9597.ENSPPAP00000016260; -.
DR Ensembl; ENSPPAT00000038954.1; ENSPPAP00000016260.1; ENSPPAG00000031248.1.
DR GeneTree; ENSGT00980000198488; -.
DR Proteomes; UP000240080; Chromosome 6.
DR Bgee; ENSPPAG00000031248; Expressed in placenta and 6 other cell types or tissues.
DR GO; GO:0033106; C:cis-Golgi network membrane; IEA:Ensembl.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0042610; F:CD8 receptor binding; IEA:Ensembl.
DR GO; GO:0042605; F:peptide antigen binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0002476; P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib; IEA:Ensembl.
DR GO; GO:0002767; P:immune response-inhibiting cell surface receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:2001199; P:negative regulation of dendritic cell differentiation; IEA:Ensembl.
DR GO; GO:0070317; P:negative regulation of G0 to G1 transition; IEA:Ensembl.
DR GO; GO:0051898; P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0001915; P:negative regulation of T cell mediated cytotoxicity; IEA:Ensembl.
DR GO; GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl.
DR GO; GO:0002451; P:peripheral B cell tolerance induction; IEA:Ensembl.
DR GO; GO:2000774; P:positive regulation of cellular senescence; IEA:Ensembl.
DR GO; GO:2000353; P:positive regulation of endothelial cell apoptotic process; IEA:Ensembl.
DR GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
DR GO; GO:0060907; P:positive regulation of macrophage cytokine production; IEA:Ensembl.
DR GO; GO:0002729; P:positive regulation of natural killer cell cytokine production; IEA:Ensembl.
DR GO; GO:0045591; P:positive regulation of regulatory T cell differentiation; IEA:Ensembl.
DR GO; GO:0002666; P:positive regulation of T cell tolerance induction; IEA:Ensembl.
DR GO; GO:0042270; P:protection from natural killer cell mediated cytotoxicity; IEA:Ensembl.
DR GO; GO:0070207; P:protein homotrimerization; IEA:Ensembl.
DR CDD; cd21022; IgC1_MHC_Ia_HLA-G; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011161; MHC_I-like_Ag-recog.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR001039; MHC_I_a_a1/a2.
DR PANTHER; PTHR16675:SF169; HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN G; 1.
DR PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00129; MHC_I; 1.
DR PRINTS; PR01638; MHCCLASSI.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..355
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015308480"
FT TRANSMEM 317..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 218..296
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 355 AA; 40005 MW; 60E97A5F7387E6E9 CRC64;
MDWRGPTPRM VVMAPRTLFL LLSGALTLTE TWAGSHSMRY FSAAVSRPGR GEPRFIAMGY
VDDTQFVWFD SDSACPRMEP RAPWVEQEGP EYWEEETRNT KAHAQTDRIN LQTLRGYYNQ
SEASSHTLQW MIGCDLGSDG RLLRGYEQYA YDGKDYLALN EDLRSWTAAD TAAQISKRKC
EAANAAEQRR AYLEGTCVEW LHRYLENGKE MLQRADPPKT HVTHHPVFDY EATLRCWALG
FYPAEIILTW QRDGEDQTQD VELVETRPAG DGTFQKWAAV VVPSGEEQRY TCHVQHEGLP
EPLMLRWKQS SLPTIPIMGI VAGLVVLAAV VTGAAVAAVL WRKKSSGKEG VTSGV
//
