ID A0A2R9AKX2_PANPA Unreviewed; 1105 AA.
AC A0A2R9AKX2;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=EvC ciliary complex subunit 2 {ECO:0000313|Ensembl:ENSPPAP00000018012.1};
GN Name=EVC2 {ECO:0000313|Ensembl:ENSPPAP00000018012.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000018012.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000018012.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000018012.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; AJFE02055960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02055961; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02055962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9AKX2; -.
DR Ensembl; ENSPPAT00000040736.1; ENSPPAP00000018012.1; ENSPPAG00000032088.1.
DR GeneTree; ENSGT00940000154127; -.
DR OMA; IFFAQIK; -.
DR Proteomes; UP000240080; Chromosome 4.
DR Bgee; ENSPPAG00000032088; Expressed in adult mammalian kidney and 5 other cell types or tissues.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:InterPro.
DR InterPro; IPR022076; Limbin.
DR InterPro; IPR026501; Limbin/EVC.
DR PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR Pfam; PF12297; EVC2_like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 219..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 704..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1085..1105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 383..410
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 927..961
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1105 AA; 125832 MW; 53252215FEF26F1B CRC64;
MIWPKVECCH FKTAVEAPLG MKLDKKMEVF IPLSTSAASS GPWAHSLFAF IPSWPKKNLF
KRESPITYRL YGDISREVQG TSENGVIFQK CALVSESSEA QTARIWLLVN NTKTTSSANL
SELLLLDSIA GLTIWDSIGN RTSEGFQAFS KKFLQVGDAF AVSYAATLQA GDLRNGESLK
LPAQLTFQSS SRNRTQLKAL FSITAEENIT VLPHHGLHAA GFFIAFLLSL VLTWAALFLM
VRYQCLKGNM LTRHRVWQYE SKLEPLPFTS ADGVNEDLSL NDQMIDILSS EDPGSMLQAL
EELEIATLNR ADADLEACRT QISKDIIALL LKSLTSSGHL SPQVERKMSA VFKKQFLLLE
SEIQEEYDRK MVALTAECDL ETRKKMENQY QREMMAMEEA EELLKRASER SAVECSNLLR
TLHGLEQEHL RKSLALQQEE DFANAHRQLA VFQRNELHSI FFTQIKSAIF KGELKPEAAK
TLLQNYSKIQ ENVEELMDFF QASKRYHLSK RFGHREYLVQ NLQSSETRVQ GLLSTAAAQL
THLIQKHERA GYLDEDQMEV LLERAQTEVF SIKQKLDNDL KQEKKKLHQK LITKRRRELL
QKHREQRREQ VSVGEAFRAV EDAGQYLHQR RSLMEEHGAA LEELQERLDQ AALDDLRTLT
LSLFEKATDE LRRLQNSAMT QELLKRGVPW LFLQQILEEH GKEMAARAEQ LEGEERDRDQ
EGVQSVRQRL KDDAPEAVTE EQAELRRWEH LIFMKLCSSV FSLSEEELLR MRQEVHGCFA
QMDRSLALPK IRSRVLLQQF QTAWREAEFV KLDQAVAALE LQQQSKVRKS RSKSKSKGEL
LKKCIEDKIH LCEEQASEDL VEKVRGELLR ERVQRMEAQE GGFAQSLVAL QFQKASRVTE
TLSAYTALLS IQDLLLEELS ASEMLTKSAC TQILESHSRE LQELERKLED QLVQQEAAQQ
QQALASWQQW VADGPGILNE PGEVDSERQV STVLQQALSK SQTLLEQHQQ CLREEQQNSV
VLEDLLENME ADTFATLCSQ ELRLASYLAR MAMVPGATLR RLLSVVLPTA SQPQLLALLD
SATERHADHA AESDGGAEQA DVGRR
//