ID A0A2R9ALH7_PANPA Unreviewed; 3229 AA.
AC A0A2R9ALH7;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Vitellogenin domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000018003.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000018003.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000018003.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00557}.
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DR EMBL; AJFE02024647; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02024648; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02024649; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02024650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02024651; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02024652; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02024653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02024654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02024655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9597.ENSPPAP00000018003; -.
DR Ensembl; ENSPPAT00000040725.1; ENSPPAP00000018003.1; ENSPPAG00000032094.1.
DR GeneTree; ENSGT00440000038757; -.
DR OMA; VLWDGQE; -.
DR Proteomes; UP000240080; Chromosome 16.
DR Bgee; ENSPPAG00000032094; Expressed in testis.
DR GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR Gene3D; 2.20.80.10; Lipovitellin-phosvitin complex, chain A, domain 4; 1.
DR Gene3D; 2.20.50.20; Lipovitellin. Chain A, domain 3; 1.
DR Gene3D; 1.25.10.20; Vitellinogen, superhelical; 1.
DR InterPro; IPR015819; Lipid_transp_b-sht_shell.
DR InterPro; IPR011030; Lipovitellin_superhlx_dom.
DR InterPro; IPR048484; LOC400499-like.
DR InterPro; IPR015816; Vitellinogen_b-sht_N.
DR InterPro; IPR015255; Vitellinogen_open_b-sht.
DR InterPro; IPR015817; Vitellinogen_open_b-sht_sub1.
DR InterPro; IPR001747; Vitellogenin_N.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR37860; AGAP008810-PA; 1.
DR PANTHER; PTHR37860:SF1; VITELLOGENIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08742; C8; 1.
DR Pfam; PF21013; LOC400499; 1.
DR Pfam; PF09172; Vit_open_b-sht; 1.
DR Pfam; PF01347; Vitellogenin_N; 1.
DR Pfam; PF00094; VWD; 1.
DR SMART; SM01169; DUF1943; 1.
DR SMART; SM00638; LPD_N; 1.
DR SUPFAM; SSF48431; Lipovitellin-phosvitin complex, superhelical domain; 1.
DR PROSITE; PS51211; VITELLOGENIN; 1.
DR PROSITE; PS51233; VWFD; 1.
PE 4: Predicted;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transport {ECO:0000256|ARBA:ARBA00023055}.
FT DOMAIN 12..619
FT /note="Vitellogenin"
FT /evidence="ECO:0000259|PROSITE:PS51211"
FT DOMAIN 2978..3148
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT REGION 658..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3229 AA; 354546 MW; ED5EB0C648D5F166 CRC64;
MTACTGSAGP HLPVGTRYTY HFSTNTSTSL QEVLVEGSGL GLQGLAVLDV LGLCQMALWL
QDFQVTSILG AKVELLKESE SLSAALGRNP LRFILHSGRV AHLCPHPTEP RWVLNVKRAV
LSLLQGHPGA HSPKTFDEVD ILGRCPTTYQ RHGDWLHKTK DLARCFLRRG RSSLHSQALP
GVAPGLTSRL TCVQSFRAGV LREASCTELD SAGPLSAKAS AVQTRTLSSL SLLHEMLQDP
AGTDPDDRDD EDMTPSSLLY EWEETPSQAM VATAATLVRR LCLAQTTSLE AMDLFLTLVS
QLQGLSGGEL MELWQYSSFK CRDNGQPLLD ALPSCGTEHC VGLMKELIAS AAVEADEAEV
WLSSLAFLPQ PTDAMVHMLL PLLQTPMASP GAFLGISALV HNLCASLDGP CGQLPGVGSL
VRILGDALGE NCTIQEPSDD DKLQLVLKAV GNAGLAAMAL TPTLSACASL RSSTPEIRLG
AIQAFRRVPC SADRSVLSRL YQSLEEDAEI RINAYLALMR CPSEEVFAQV RRTQAGELST
QVGSFVWSHL LQLLETHDPL KRALRDTLPE DILSQEFHPE MWKHSSYSDV TFRSASGSLG
ANLEGTLLFS PASFLPRSAT VNLTVHTMGR AFNLLELGLR LENAEEIAHR LFGRKSFWGQ
EDRREPEPEK PPGPEPGPAP QPASPKCPGD RDRRMRYLQQ KVTRRRGARQ ALRCELSVKL
LGQELSFVNC GATGSHVNHW PLNLAELAIK LMKGQEVQMN RRLSLAAEEL VFPTVSGLPA
RLTLNASAAI SIRVRGTTDF QQRSDFSVNG YVKPSALLQI SAQMGTAGIL GQAGLRWVTS
VRSAASLDGG IQVQKGRDLK VHLNTPEEAV ELLSFSSQLY LITRDGVRSL RHVPGPSEVQ
SCTGEEVSYT WGWRLCTGVT WPVPGQPYLL SLPVFAAVTL QKRDPGLRQY LLEAAYTLQP
QKDSWFPQEA TAHVFMGTPG SEVLRDVGVD ISYSLPQNKF RLKLLHPKKK IELDGKMEAL
GSAHTGHLEL VLDDRDVYYI KGWSDLQPAM GGEAERFQAQ VEVKLVTGGS PVVFTGNLTR
QAGSKLAFSA SLSHLLSDQA NVTALLERKE ENGRWVAALG AELFVPGLVG LRALGLLQQR
GQLWTNSLRI QYSLLGQAKQ AAHECSTSQK LRADSGSDGA YRLELRHELH CTQIPAFSHK
VQLWHEEDSD HLHSQLEVSY GKHWDKNSNK RHLRVSQTFK NDSGPALSNH FMEFVLQVPE
RQVDCRVQLH HLSLRLPYME SSSHLKVQYN GRPLFVAGGQ WKDTSRATLW KWEGALNLDS
PWLMVSAAHR LYWPHRAVFQ AVLELTLGKA WTLKDLVVSV GCRSQGPNRE GKIQVYTAAT
TYLRVSTVTV LAQSLFHSWS ELESAWNAAV QGEIHAENSR DRKILNCWLK GPQQELNLTA
AYRHLERPRK TQVSLTAVRI GAQGQPRGLQ LEGELEELRQ DRTLYRKRGA LLLRHPLHLP
IPQSLLLQET FTADRRHQRY SLETRVVLNG REETLQTVVL GCQAGHPYVC AGLTHPYDGK
VIPRNTEGCL VTWNQHTAKN REVEATLKVD RKVVLHLKGL HHDRSQHGEI RHSLALDLAH
SYQLSFPQAL SLDGGIIFRH SPQGTFNFGM DARAAVNHNV TSQASVHLNG SDSDFAFFFQ
LRHPHGPTFP PNFQVQAAAG RYRVRSLNGS LSVQMSGREL VLLEVDASQD TRRSSRGWGV
SVLLHQAVLS APRAVRLQLS AKITPARIWL FSKALLDQNT AQLLLKASEE WRGGRILTFQ
SQTRHTVAGW AAMPRLLTLT GRLKQKETLQ EGTLRVTADS AVLGFLLRDK HEKAGNGTSV
RSVTCVLAQN SSQALPGELQ LKGRLQAQTR NLRAQASIRA HAASLALGGA CSWGPRHGQL
AGGLTHNIST LSDAGLPSEA GMLLSLTHMA SNCSARLALR NAGGQLDAAI GLEDLTPESP
GLQLHASFRH THTMPSLKHW GLPFSLDGHG HFQVNCSGDA SPTQLSGRCR GDIAGQPLEV
SVDIHNGSSG FEHSGRILMG PTFLNYSVSC CYHDEHLELS GRSWHNSEAL LWAGFPGEAC
LSAELQIHET QTQARVALHG GDSGVTMDLA ALVAWPRRGP LQLVANASHT VPALQRLGLP
FTNQLMFQGL WEAEEMSSSL QLTCDSQATL VLDVHGQNQA VSKELLFSGR HRLPFLLGLC
PSSASASAKL HYSKGEVQSM FALGMEERHF HISTWQVAAK AGLNNFIKLE QTFLQLSALP
RELFLQTTYE RARGTRVLRQ VVLWDGQEVA LTGSLSGPFP KPTRNLSLQV ELTHPLPLPL
PRHCSLRLSS EHLGGSHRDG LVVGWDGRDQ VLVSSSLWLG KSELAARLAL AHPFNLSWRQ
AEASGLAESR GGRQSRQVQL TWNRGQPATL QLTWADGSLA HSTAWDGCLA ASPGQLQETW
GLNTLQACGA FMQTPAVFVE QLDVSWGQHR MRQNLTYERH WPSQPDKIIM EATLEHVLGA
SCTRQSFWGE VQTDYARWLR HSLHLGLCDL PRALLVVGEH TLGQGGLLLR SRCHLGLAPD
PDHGLHLSLT LQNHSRPRSA DFSGALELRG SKAQRVGLLG RVSTSTSQSL VRLEGSVDNR
EEKVRLSVFR APSCLQASVA HEEGGREESV VLRACAHGWT AEAEVLFRDG RQPSQPLGRL
TLQAANQSLL LAARGCQGDL LGHVESRIAA VGSQVQARLE EKVQGLGASV RRFQQLVQPA
GTLDGVAGLL LQLSQAGREA MQASGWAVAT LWARSQALTQ HLPLYLEWLQ VGLEQLREEL
EWPLATLKDA YLEVTLRPLE EVWRERAEEA MRRLQAWVPG MPGNGGPRPI RAALGAMKGA
LELAAHQMLS WAEATFSRAL KRLCKPLLDL YSLSARNRSV VVTLPLLPAG DEPLDVARVT
SYLVEEKLLR PLRELSGANV LAEYYWLRRR LLAGPWEYHA LVAGAQHVVT FDGRVWDLSA
QCGSILLAQD FAHNTFSLML SRTGSGLTAL FVELNRKTLI LYPSLQAYRL YNSSLPGDSC
PDLKLHPATT RKDVSRIELA SEDGVSVSCD MPTGLCSLTL GLWQHGISAG LLGTNDNEAG
NELMLPDGSM AHSLEELSLA WQVGGDCRAT EKPQQACPGQ LPTCRAFFED PHSSLRNCFR
VVDPTPFLSL CVQDPCGTQE LQPACNLVAT YIHLCARGFV PLAPPPQCV
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