GenomeNet

Database: UniProt
Entry: A0A2R9ALR1_PANPA
LinkDB: A0A2R9ALR1_PANPA
Original site: A0A2R9ALR1_PANPA 
ID   A0A2R9ALR1_PANPA        Unreviewed;       235 AA.
AC   A0A2R9ALR1;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Zinc transporter ZIP9 {ECO:0000256|ARBA:ARBA00026135, ECO:0000256|RuleBase:RU369011};
DE            Short=ZIP-9 {ECO:0000256|RuleBase:RU369011};
DE   AltName: Full=Solute carrier family 39 member 9 {ECO:0000256|ARBA:ARBA00031674, ECO:0000256|RuleBase:RU369011};
DE   AltName: Full=Zrt- and Irt-like protein 9 {ECO:0000256|ARBA:ARBA00031377, ECO:0000256|RuleBase:RU369011};
GN   Name=SLC39A9 {ECO:0000313|Ensembl:ENSPPAP00000015914.1};
OS   Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000015914.1, ECO:0000313|Proteomes:UP000240080};
RN   [1] {ECO:0000313|Ensembl:ENSPPAP00000015914.1, ECO:0000313|Proteomes:UP000240080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22722832; DOI=10.1038/nature11128;
RA   Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA   Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA   Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA   Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA   Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA   Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA   Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA   Paabo S.;
RT   "The bonobo genome compared with the chimpanzee and human genomes.";
RL   Nature 486:527-531(2012).
RN   [2] {ECO:0000313|Ensembl:ENSPPAP00000015914.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Transports zinc ions across cell and organelle membranes into
CC       the cytoplasm and regulates intracellular zinc homeostasis.
CC       Participates in the zinc ions efflux out of the secretory compartments.
CC       Also functions as membrane androgen receptor that mediates, through a G
CC       protein, the non-classical androgen signaling pathway, characterized by
CC       the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1
CC       or ATF1. Moreover, has dual functions as membrane-bound androgen
CC       receptor and as an androgen-dependent zinc transporter both of which
CC       are mediated through an inhibitory G protein (Gi) that mediates both
CC       MAP kinase and zinc signaling leading to the androgen-dependent
CC       apoptotic process. {ECO:0000256|RuleBase:RU369011}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351,
CC         ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00034634};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU369011};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU369011}. Cytoplasm,
CC       perinuclear region {ECO:0000256|ARBA:ARBA00004556,
CC       ECO:0000256|RuleBase:RU369011}. Golgi apparatus, trans-Golgi network
CC       membrane {ECO:0000256|ARBA:ARBA00004198,
CC       ECO:0000256|RuleBase:RU369011}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC       {ECO:0000256|ARBA:ARBA00004173, ECO:0000256|RuleBase:RU369011}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU369011}.
CC   -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC       {ECO:0000256|RuleBase:RU369011}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU369011}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJFE02084737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJFE02084738; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJFE02084739; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJFE02084740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A2R9ALR1; -.
DR   Ensembl; ENSPPAT00000038607.1; ENSPPAP00000015914.1; ENSPPAG00000031046.1.
DR   GeneTree; ENSGT00390000010094; -.
DR   Proteomes; UP000240080; Chromosome 14.
DR   Bgee; ENSPPAG00000031046; Expressed in liver and 6 other cell types or tissues.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005385; F:zinc ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   InterPro; IPR003689; ZIP.
DR   InterPro; IPR045891; ZIP9.
DR   PANTHER; PTHR16133; SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED; 1.
DR   PANTHER; PTHR16133:SF5; ZINC TRANSPORTER ZIP9; 1.
DR   Pfam; PF02535; Zip; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Glycoprotein {ECO:0000256|RuleBase:RU369011};
KW   Ion transport {ECO:0000256|RuleBase:RU369011};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU369011};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU369011};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU369011}; Transport {ECO:0000256|RuleBase:RU369011};
KW   Zinc {ECO:0000256|RuleBase:RU369011};
KW   Zinc transport {ECO:0000256|RuleBase:RU369011}.
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369011"
FT   TRANSMEM        104..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369011"
FT   TRANSMEM        138..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369011"
FT   TRANSMEM        169..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369011"
FT   TRANSMEM        211..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369011"
SQ   SEQUENCE   235 AA;  24957 MW;  C416B40A3440D95F CRC64;
     MNMSTATTTH SCMPILVFPS FWASFSCCWW TRLVTPMCIL LTPTQCEDDE DENLYDDPLP
     LNNPEAARSS NSKITTTLGL VVHAAADGVA LGAAASTSQT SVQLIVFVAI MLHKAPAAFG
     LVSFLMHAGL ERNRIRKHLL VFALAAPVMS MVTYLGLSKS SKEALSEVNA TGVAMLFSAG
     TFLYVATVHV LPEVGGIGHS HKPDATGGRG LSRLEVAALV LGCLIPLILS VGHQH
//
DBGET integrated database retrieval system