ID A0A2R9ALT6_PANPA Unreviewed; 1164 AA.
AC A0A2R9ALT6;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Calcium-activated potassium channel subunit alpha-1 {ECO:0000256|ARBA:ARBA00018044};
DE AltName: Full=BK channel {ECO:0000256|ARBA:ARBA00029579};
DE AltName: Full=BKCA alpha {ECO:0000256|ARBA:ARBA00030518};
DE AltName: Full=Calcium-activated potassium channel, subfamily M subunit alpha-1 {ECO:0000256|ARBA:ARBA00030288};
DE AltName: Full=K(VCA)alpha {ECO:0000256|ARBA:ARBA00031597};
DE AltName: Full=KCa1.1 {ECO:0000256|ARBA:ARBA00030652};
DE AltName: Full=Maxi K channel {ECO:0000256|ARBA:ARBA00031999};
DE AltName: Full=Slo-alpha {ECO:0000256|ARBA:ARBA00029583};
DE AltName: Full=Slo1 {ECO:0000256|ARBA:ARBA00030326};
DE AltName: Full=Slowpoke homolog {ECO:0000256|ARBA:ARBA00033447};
GN Name=KCNMA1 {ECO:0000313|Ensembl:ENSPPAP00000018108.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000018108.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000018108.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000018108.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the potassium channel family. Calcium-activated
CC (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
CC {ECO:0000256|ARBA:ARBA00008648}.
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DR EMBL; AJFE02041474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02041475; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02041476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02041477; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02041478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02041479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02041480; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02041481; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02041482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02041483; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9ALT6; -.
DR Ensembl; ENSPPAT00000040837.1; ENSPPAP00000018108.1; ENSPPAG00000031977.1.
DR GeneTree; ENSGT00940000154935; -.
DR Proteomes; UP000240080; Chromosome 10.
DR Bgee; ENSPPAG00000031977; Expressed in prefrontal cortex and 6 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022839; F:monoatomic ion-gated channel activity; IEA:UniProt.
DR GO; GO:0005267; F:potassium channel activity; IEA:UniProt.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR048735; Slowpoke-like_C.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF28; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1; 1.
DR Pfam; PF03493; BK_channel_a; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF21014; Slowpoke_C; 1.
DR PRINTS; PR01449; BKCHANNELA.
DR PRINTS; PR00169; KCHANNEL.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 73..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 354..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 168..383
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 533..620
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
FT DOMAIN 984..1104
FT /note="Ca2+-activated K+ channel Slowpoke-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21014"
FT REGION 24..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 691..715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1114..1164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 695..712
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1114..1145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1146..1164
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1164 AA; 129956 MW; 65AA3A8A260FC968 CRC64;
GGGGGGGGSS LRMSSNIHAN HLSLDASSSS SSSSSSSSSS SSSSSSSVHE PKMDALIIPV
TMEVPCDSRG QRMWWAFLAS SMVTFFGGLF IILLWRTLKY LWTVCCHCGG KTKEAQKINN
GSSQADGTLK PVDEKEEAVA AEVGWMTSVK DWAGVMISAQ TLTGRVLVVL VFALSIGALV
IYFIDSSNPI ESCQNFYKDF TLQIDMAFNV FFLLYFGLRF IAANDKLWFW LEVNSVVDFF
TVPPVFVSVY LNRSWLGLRF LRALRLIQFS EILQFLNILK TSNSIKLVNL LSIFISTWLT
AAGFIHLVEN SGDPWENFQN NQALTYWECV YLLMVTMSTV GYGDVYAKTT LGRLFMVFFI
LGGLAMFASY VPEIIELIGN RKKYGGSYSA VSGRKHIVVC GHITLESVSN FLKDFLHKDR
DDVNVEIVFL HNISPNLELE ALFKRHFTQV EFYQGSVLNP HDLARVKIES ADACLILANK
YCADPDAEDA SNIMRVISIK NYHPKIRIIT QMLQYHNKAH LLNIPSWNWK EGDDAICLAE
LKLGFIAQSC LAQGLSTMLA NLFSMRSFIK IEEDTWQKYY LEGVSNEMYT EYLSSAFVGL
SFPTVCELCF VKLKLLMIAI EYKSANRESR ILINPGNHLK IQEGTLGFFI ASDAKEVKRA
FFYCKACHDD ITDPKRIKKC GCKRLEDEQP STLSKKKQRN GGMRNSPNTS PKLMRHDPLL
IPGNDQIDNM DSNVKKYDST GMFHWCAPKE IEKVILTRSE AAMTVLSGHV VVCIFGDVSS
ALIGLRNLVM PLRASNFHYH ELKHIVFVGS IEYLKREWET LHNFPKVSIL PGTPLSRADL
RAVNINLCDM CVILSANQNN IDDTSLQDKE CILASLNIKS MQFDDSIGVL QANSQGFTPP
GMDRSSPDNS PVHGMLRQPS ITTGVNIPII TELVNDTNVQ FLDQDDDDDP DTELYLTQPF
ACGTAFAVSV LDSLMSATYF NDNILTLIRT LVTGGATPEL EALIAEENAL RGGYSTPQTL
ANRDRCRVAQ LALLDGPFAD LGDGGCYGDL FCKALKTYNM LCFGIYRLRD AHLSTPSQCT
KRYVITNPPY EFELVPTDLI FCLMQFDHNA GQSRASLSHS SHSSQSSSKK SSSVHSIPST
ANRQNRPKSR ESRDKQNRKE MVYR
//
