ID A0A2R9AM41_PANPA Unreviewed; 7557 AA.
AC A0A2R9AM41;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Microtubule actin crosslinking factor 1 {ECO:0000313|Ensembl:ENSPPAP00000018426.1};
GN Name=MACF1 {ECO:0000313|Ensembl:ENSPPAP00000018426.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000018426.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000018426.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000018426.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; AJFE02051263; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02051264; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02051265; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02051266; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02051267; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02051268; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02051269; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02051270; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02051271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02051272; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPPAT00000041158.1; ENSPPAP00000018426.1; ENSPPAG00000032133.1.
DR GeneTree; ENSGT00940000155824; -.
DR Proteomes; UP000240080; Chromosome 1.
DR Bgee; ENSPPAG00000032133; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd21240; CH_MACF1_rpt2; 1.
DR CDD; cd21188; CH_PLEC-like_rpt1; 1.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00176; SPEC; 16.
DR Gene3D; 1.20.58.1060; -; 1.
DR Gene3D; 1.20.58.60; -; 33.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.920.20; Gas2-like domain; 1.
DR Gene3D; 3.90.1290.10; Plakin repeat; 5.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR003108; GAR_dom.
DR InterPro; IPR036534; GAR_dom_sf.
DR InterPro; IPR049538; PCN-like_spectrin-like_rpt.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF23; SHORT STOP, ISOFORM H; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF02187; GAS2; 1.
DR Pfam; PF00681; Plectin; 10.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF00435; Spectrin; 17.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21019; Spectrin_3; 1.
DR Pfam; PF21020; Spectrin_4; 1.
DR Pfam; PF21097; SR_plectin_7; 1.
DR SMART; SM00033; CH; 2.
DR SMART; SM01129; DELLA; 1.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00243; GAS2; 1.
DR SMART; SM00250; PLEC; 20.
DR SMART; SM00150; SPEC; 34.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF143575; GAS2 domain-like; 1.
DR SUPFAM; SSF75399; Plakin repeat; 6.
DR SUPFAM; SSF46966; Spectrin repeat; 32.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS51460; GAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 41..176
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 189..293
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 863..920
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 7144..7179
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 7180..7215
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 7220..7298
FT /note="GAR"
FT /evidence="ECO:0000259|PROSITE:PS51460"
FT REGION 2043..2080
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3007..3030
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3100..3173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3318..3347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5689..5709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7054..7084
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7301..7392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7412..7557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 472..524
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1398..1428
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1492..1537
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3565..3603
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3693..3727
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3857..3887
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4251..4318
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4680..4755
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4993..5034
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 6194..6221
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2047..2071
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3121..3153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3154..3173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5693..5708
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7308..7324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7356..7392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7427..7472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7504..7557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 7557 AA; 857340 MW; 78182DEB8BF8462B CRC64;
MPLLDSSYLP PTIFILTHVL GVAGVLYWKR HARGRADERD RVQKKTFTKW VNKHLMKVRK
HINDLYEDLR DGHNLISLLE VLSGIKLEPA GLKTLRLVSM PSWRHTNNEE QMEEDDDDVP
REKGRMRFHR LQNVQIALDF LKQRQVKLVN IRNDDITDGN PKLTLGLIWT IILHFQISDI
YISGESGDMS AKEKLLLWTQ KVTAGYTGIK CTNFSSCWSD GKMFNALIHR YRPDLVDMER
VQIQSNRENL EQAFEVAERL GVTRLLDAED VDVPSPDEKS VITYVSSIYD AFPKVPEGGE
GISATEVDSR WQEYQSRVDS LIPWIKQHTI LMSDKTFPQN PVELKALYNQ YIHFKETEIL
AKEREKGRIE ELYKLLEVWI EFGRIKLPQG YHPNDVEEEW GKLIIEMLER EKSLRPAVER
LELLLQIANK IQNGALNCEE KLTLAKNTLQ ADAAHLESGQ PVQCESDVIM YIQECEGLIR
QLQVDLQILR DENYYQLEEL AFRVMRLQDE LVTLRLECTN LYRKGHFTSL ELVPPCTLTT
THLKAEPLTK ATHSSSTSWF RKPMTRAELV AISSSEDEGN LRFVYELLSW VEEMQMKLER
AEWGNDLPSV ELQLETQQHI HTSVEELGSS VKEARLYEGK MSQNFHTSYA ETLGKLETQY
CKLKETSSFR MRHLQSLHKF VSRATAELIW LNEKEEEELA YDWSDNNSNI SAKRNYFSEL
TMELEEKQDV FRSLQDTAEL LSLENHPAKQ TVEAYSAAVQ SQLQWMKQLC LCVEQHVKEN
TAYFQFFSDA RELESFLRNL QDSIKRKYSC DHNTSLSRLE DLLQDSMDEK EQLIQSKSSV
ASLVGRSKTI VQLKPRSPDH VLKNTISVKA VCDYRQIEIT ICKNDECVLE DNSQRTKWKV
ISPTGNEAMV PSVCFLIPPP NKDAIEMASR VEQSYQKVMA LWHQLHVNTK SLISWNYLRK
DLDLVQTWNL EKLRSSAPGE CHQIMKNLQA HYEDFLQDSR DSVLFSVADR LRLEEEVEAC
KARFQHLMKS MENEDKEETV AKMYISELKN IRLRLEEYEQ RVVKRIQSLA SSRTDRDARQ
DNALRIAEQE HTQEDLQQLR SDLDAVSMKC DSFLHQSPSS SSVPTLRSEL NLLVEKMDHV
YGLSTVYLNK LKTVDVIVRS IQDAELLVKG YEIKLSQEEV VLADLSALEA HWSTLRHWLS
DVKDKNSVFS VLDEEIAKAK AVAEQMSRLT PERNLDLERY QEKGSQLQER WHRVIAQLEI
RQSELESIQE VLGDYRACHG TLIKWIEETT AQQEMMKPGQ AEDSRVLSEQ LSQQTALFAE
IERNQTKLDQ CQKFSQQYST IVKDYELQLM TYKAFVESQQ KSPGKRRRML SSSDAITQEF
MDLRTRYTAL VTLTTQHVKY ISDALRRLEE EEKVVEEEKQ EHVEKVKELL GWVSTLARNT
QGKATSSETK ESTDIEKAIL EQQVLSEELT TKKEQVSEAI KTSQIFLAKH GHKLSEKEKK
QISEQLNALN KAYHDLCDGS ANQLQQLQSQ LAHQTEQKEC RAVAGVIDLG TVEIFPIFKA
MQKGLLDQDT GLVLLESQVI MSGLIAPETG ENLSLEEGIA RNLINPQMYQ QLRELQDALA
LISRLTESRG PLSVVEAIEK RIISERVGLK ILEAHLATGG FSLSPSENCI NLEEAFHQGL
ISAWLHSVLE SYLRTSKNLI DPNTAEKIGL LDLMQRCIVH QESGFKLLPV KQLAGGMVSL
KSGLKVSIFR AVQEGLIDRQ VTVRLLEAQL FAGGIVDPRT GHRLTVEEAV RHNLIDQDMA
CAILIRQLQT GGIIDTVTGQ RLTIDEAVSN DLVAAKIALV ILESLWSFMG LLWPESGEIL
PITDALEQGI VSTELAHKIL SNRQHIKALF LPATTEILSW KKAIESGILD RDLANNLKSI
CIPDVMPHMQ LADSAEQNIN PGAAVLPCSK SHPKAIASQS ENLLFQLMTH SYINVQNGQR
LLLLDKELME TLTSRDEYQT SPPKMVEIGH QRQKTPEGLQ ESANVKISGT FSDGWTVRLP
EFQFSSQNKE HPDREDCTTE KGKKTTVETE DSSVENPEQD LFVEQKERNP NVDALKVINK
VKLEVQRQLI GTKREDQTAV SIRENASRGH LLTIPPAEAE GVPLVVDKDV FSVETPKKEH
QPLRNTSFTC QNEQAHTLET EYIHDETGGS HIKPQSKKSQ VQVKKTLGIK LELKSETDGN
VHPLDKKEML KKTFLAKDDH KESQEAQNIA GGSMMMSEKT DEEDSGREIF LSFSHPLELL
EEATLNVLSA QLLDGGIFHE QTGQKLLLNE AISRGIVPSH TAVKLMEKLN MFQGFFDSQT
CESLTTEEVI NEGLMDEKLL HNVLMADKAI SGVLDPRTQT LCSVKDAVTV GLLDKETATR
ILERQVVTGG IIDLKRGKKV SVTLASTLGL VDVADQPELI NLEKASKGRD AEKTVRERLI
SLQIETTGLI DPDSKAPLTV VQSIDRGLLE REEAVRLLTK QVVDGGIIHH ISGMRLSVDN
AFRHGLIGED LAEKLKRVEN LNIHQIFNPE TKENVSLPKA IKLDLITPDL KREIQEVQAF
TGNFVDLISG QRLTLAEAKK EGLLTNEAVL SPGMMHGIVD PENCRIVPYS ELVKKCKIDI
ESGQRYLEVI PFSDIKDGVS DKVLTLSQAI QLGKVDFAST LKVLEAQANT GGIIDTATGK
RLTLASALEE KLVDENMVRI IASHQVLNGG IVDIFSDQRV TLVEAIEKRL ISPELANMIQ
IDSSEFSNHR AQIEKQAGIE VCALQNEFLR KDMLIACNQT AEMSCNKVEE SERLFQVENQ
SAQEKVKVRV SDGEQAKKSR EISLKEFGCK DQRKPRMSSD AKEFISIINP HNLKGKSLGQ
VSLTHPYSEV CDFKLKEVAR NNMGNDTNEE QEKAVTKIEI ISHMKQSTSC LDSEEIRENQ
GEVILEVQET YCETSGKLPS EQVLQQPMNA GVKSKREKRE VIVEESIRTC KPAFLSEEKL
YQETAIRDEH DSHIKSQPRE MTSSEKGKEA DTEMGFSITF KIEESSSQVV PQGISVKHLD
ALTLFSSKQA NEGKVNNLSL CLTLKPEENL SREIACGAQS EPFPCMTPRP EGLHYQESDG
KAQVTGPSQI SKTDKSFQGT TRQETNYHQD SWVTSKTKET KHQISSSNEC KEKSYQEVSF
DPARGLKLEE ITVSRPDSKE VRYLEFSDRK DLHHQGSKSD DKLCGTLKSE IATQELTGEK
FLEMANPNVA GLEAGSIEDI VTQRGSRVLG SFLPEKLFKG VSQKENTGQQ NAIISPTVLE
TSEERTVSLT VCSAVKTEKT PQEKLRESPG SEQTPFMTAP EGKGNGGVNP EPFRATQNVF
TRQLCLEHDE KLVSYLSLLR NIEMRTKQIQ PLELNLAELQ DLLCQAKVLD RELKDLTTLV
SQELECVNQI IISQPQEVPA QLLKALEKDA KNLQKSLSSV SDTWNSRLLH FQNAVEIEKT
KVLNQHTQLE GRLQDLRAWV GNKNLILNSK GSNSEIDVDS LNRCLQQYED LKQPMAERKA
QLDALAFDIQ FFISEHAQDL SPQQNRQMLR LLNELQRSFQ DILEQTAAQV DALQGHLQQM
EQEALVKTLQ KQQNTCHQQL EDLCSWVGQA ERALAGHQGR TTQRDLSALQ KNQSDLKDLQ
DDIQNRATSF ATVVKDIEGF MEENQTKLSP RELTALREKL HQAKEQYEAL QEETRVAQKE
LEEAVTSALQ QETEKSKAAK ELAENKKKID ALLDWVTSVG SSGGQLLTNL PGMEQLSGAS
LEKGALDTTD GYMGVNQAPE KLDKQCEMMK ARHQELLSQQ QNFILATQSA QAFLDQHGHN
LTPEEQQMLQ QKLGELKEQY STSLAQSEAE LKQVQTLQDE LQKFLQDHRE FESWLERSEK
ELENMHKGGS SPEALPSLLK WQGSFSEDVI SHKGDLRFVT ISGQKVLDME NSFKEGKEPS
EIGNLVKDKL KDATERYTAL HSKCTRLGSH LNMLLGQYHQ FQNSADSLQA WMQACEANVE
KLLSDTVASD PGVLQEQLAT TKQLQEELAE HQVPVEKLQK VARDIMEIEG EPAPDHRHVQ
ETTDSILSHF QSLSYSLAER SSLLQKAIAQ SQSVQESLES LLQSIGEVEQ NLEGKQVSSL
SSGVIQEALA TNMKLKQDIA RQKSSLEATR EMVTRFMETA DSTTAAVLQG KLAEVSQRFE
QLCLQQQEKE SSLKKLLPQA EMFEHLSGKL QQFMENKSRM LASGNQPDQD ITHFFQQIQE
LNLEMEDQQE NLDTLEHLVT ELSSCGFALD LCQHQDRVQN LRKDFTELQK TVKEREKDAS
SCQEQLDEFR KLVRTFQKWL KETEGSIPPT ETSMSAKELE KQIEHLKSLL DDWASKGTLV
EEINCKGTSL ENLIMEITAP DSQGKTGSIL PSVGSSVGSV NGYHTCKDLT EIQCDMSDVN
LKYEKLGGVL HERQESLQAI LNRMEEVHKE ANSVLQWLES KEEVLKSMDA MSSPTKTETV
KAQAESNKAF LAELEQNSPK IQKVKEALAG LLVTYPNSQE AENWKKIQEE LNSRWERATE
VTVARQRQLE ESASHLACFQ AAESQLRPWL MEKELMMGVL GPLSIDPNML NAQKQQVQFM
LKEFEARRQQ HEQLNEAAQG ILTGPGDVSL STSQVQKELQ SINQKWVELT DKLNSRSSQI
DQAIVKSTQY QELLQDLSEK VRAVGQRLSV QSAISTQPEA VKQQLEETSE IRSDLEQLDH
EVKEAQTLCD ELSVLIGEQY LKDELKKRLE TVALPLQGLE DLAADRMNRL QAALASTQQF
QQMFDELRTW LDDKQSQQAK NCPISAKLER LQSQLQENEE FQKSLNQHSG SYEVIVAEGE
SLLLSVPPGE EKRTLQNQLV ELKNHWEELS KKTADRQSRL KDCMQKAQKY QWHVEDLVPW
IEDCKAKMSE LRVTLDPVQL ESSLLRSKAM LSEVEKRRSL LEILNSAADI LINSSEADED
GIRDEKAGIN QNMDAVTEEL QAKTGSLEEM TQRLKEFQES FKNIEKKVEG AKHQLEIFDA
LGSQACSNKN LEKLRAQQEV LQALEPQVDY LRNFTQGLVE DAPDGSDASQ LLHQAEVAQQ
EFLEVKQRVN SGCVMMENKL EGIGQFHCRV REMFSQLADL DDELDGMGAI GRDTDSLQSQ
IEDVRLFLNK IHILKLDIEA SEAECRHMLE EEGTLDLLGL KRELEALNKQ CGKLTERGKA
RQEQLELTLG RVEDFYRKLK GLNDATTAAE EAEALQWVVG TEVEIINQQL ADFKMFQKEQ
VDPLQMKLQQ VNGLGQGLIQ SAGKDCDVQG LEHDMEEINA RWNTLNKKVA QRIAQLQEAL
LHCGKFQDAL EPLLSWLADT EELIANQKPP SAEYKVVKAQ IQEQKLLQRL LDDRKATVDM
LQAEGGRIAQ SAELADREKI TGQLESLESR WTELLSKAAA RQKQLEDILV LAKQFHETAE
PISDFLSVTE KKLANSEPVG TQTAKIQQQI IRHKALEEDI ENHATDVHQA VKIGQSLSSL
TSPAEQGVLS EKIDSLQARY SEIQDRCCRK AALLDQALSN ARLFGEDEVE VLNWLAEVED
KLSSVFIKDF KQDVLHRQHA DHLALNEEIV NRKKNVDQAI KNGQALLKQT TGEEVLLIQE
KLDGIKTRYA DITVTSSKAL RTLEQARQLA TKFQSTYEEL TGWLREVEEE LATSGGQSPT
GEQIPQFQQR QKELKKEVME HRLVLDTVNE VSRALLELVP WRAREGLDKL VSDANEQYKL
VSDTIGQRVD EIDAAIQRSQ QYEQAADAEL AWVAETKRKL MALGPIRLEQ DQTTAQLQVQ
KAFSIDIIRH KDSMDELFSH RSEIFGTCGE EQKTVLQEKT ESLIQEYEAI SLLNSERYAR
LERAQVLVNQ FWETYEELSP WIEETRALIA QLPPPAIDHE QLRQQQEEMR QLRESIAEHK
PHIDKLLKIG PQLKELNPEE GEMVEEKYQK AENMYAQIKE EVRQRALALD EAVSQSTQFH
DKIEPMLETL ENLSSRLRMP PLIPAEVDKI RECISDNKSA TVELEKLQPS FEALKRRGEE
LIGRSQGADK DLAAKEIQDK LDQMVFFWED IKARAEEREI KFLDVLELAE KFWYDMAALL
TTIKDTQDIV HDLESPGIDP SIIKQQVEAA ETIKEETDGL HEELEFIRIL GADLIFACGE
TEKPEVRKSI DEMNNAWENL NKTWKERLEK LEDAMQAAVQ YQDTLQAMFD WLDNTVIKLC
TMPPVGTDLN TVKDQLNEMK EFKVEVYQQQ IEMEKLNHQG ELMLKKATDE TDRDIIREPL
TELKHLWENL GEKIAHRQHK LEGALLALGQ FQHALEELMS WLTHTEELLD AQRPISGDPK
VIEVELAKHH VLKNDVLAHQ ATVETVNKAG NELLESSAGD DASSLRSRLE TMNQCWESVL
QKTEEREQQL QSTLQQAQGF HSEIEDFLLE LTRMESQLSA SKPTGGLPET AREQLDTHME
LYSQLKAKEE TYNQLLDKGR LMLLSRDDSG SGSKTEQSVA LLEQKWHVVS SKMEERKSKL
EEALNLATEF QNSLQEFINW LTLAEQSLNI ASPPSLILNT VLSQIEEHKV FANEVNAHRD
QIIELDQTGN QLKFLSQKQD VVLIKNLLVS VQSRWEKVVQ RSIERGRSLD DARKRAKQFH
EAWKKLIDWL EDAESHLDSE LEISNDPDKI KLQLSKHKEF QKTLGGKQPV YDTTIRTGRA
LKEKTLLPED TQKLDNFLGE VRDKWDTVCG KSVERQHKLE EALLFSGQFM DALQALVDWL
YKVEPQLAED QPVHGDLDLV MNLMDAHKVF QKELGKRTGT VQVLKRSGRE LIENSRDDTT
WVKGQLQELS TRWDTVCKLS VSKQSRLEQA LKQAEVFRDT VHMLLEWLSE AEQTLRFRGA
LPDDTEALQS LIDTHKEFMK KVEEKRVDVN SAVAMGEVIL AVCHPDCITT IKHWITIIRA
RFEEVLTWAK QHQQRLETAL SELVANAELL EELLAWIQWA ETTLIQRDQE PIPQNIDRVK
ALIAEHQTFM EEMTRKQPDV DRVTKTYKRK NIEPTHAPFI EKSRSGGRKS LSQPTPPPMP
ILSQSEAKNP RINQLSARWQ QVWLLALERQ RKLNDALDRL EELKEFANFD FDVWRKKYMR
WMNHKKSRVM DFFRRIDKDQ DGKITRQEFI DGILASKFPT TKLEMTAVAD IFDRDGDGYI
DYYEFVAALH PNKDAYRPTT DADKIEDEVT RQVAQCKCAK RFQVEQIGEN KYRFFLGNQF
GDSQQLRLVR ILRSTVMVRV GGGWMALDEF LVKNDPCRVH HPGSKIKRSD SSSSISSQSP
IARGRTNIEL REKFILPEGA SQGMTPFRSR GRRSKPSSRA ASPTRSSSSA SQSNHSCTSM
PSSPATPASG TKTSLQFSRC YDKPWLVNSK AGTPIRDSHS PDLQLPTPEV IPSSGSKLKR
PTPTFHSSRT SLAGDTSNSS SPASTGAKTN RADPKKSASR PGSRAGSRAG SRASSRRGSD
ASDFDLLETQ SACSDTSESS AAGGQGNSRR GLNKPSKIPT MSKKTTTASP RTPGPKR
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