ID A0A2R9AMF1_PANPA Unreviewed; 280 AA.
AC A0A2R9AMF1;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Trans-2,3-enoyl-CoA reductase {ECO:0000313|Ensembl:ENSPPAP00000016870.1};
GN Name=TECR {ECO:0000313|Ensembl:ENSPPAP00000016870.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000016870.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000016870.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000016870.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the steroid 5-alpha reductase family.
CC {ECO:0000256|ARBA:ARBA00007742}.
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DR EMBL; AJFE02020193; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02020194; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02020195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02020196; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02020197; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02020198; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9AMF1; -.
DR Ensembl; ENSPPAT00000039569.1; ENSPPAP00000016870.1; ENSPPAG00000031488.1.
DR GeneTree; ENSGT00950000182886; -.
DR OMA; WAWKKEK; -.
DR Proteomes; UP000240080; Chromosome 19.
DR Bgee; ENSPPAG00000031488; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR Gene3D; 1.20.120.1630; -; 1.
DR InterPro; IPR001104; 3-oxo-5_a-steroid_4-DH_C.
DR InterPro; IPR039357; SRD5A/TECR.
DR InterPro; IPR049127; TECR-like_N.
DR PANTHER; PTHR10556; 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE; 1.
DR PANTHER; PTHR10556:SF31; VERY-LONG-CHAIN ENOYL-COA REDUCTASE; 1.
DR Pfam; PF02544; Steroid_dh; 1.
DR Pfam; PF21696; TECR_N; 1.
DR PROSITE; PS50244; S5A_REDUCTASE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 57..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 169..255
FT /note="Steroid 5-alpha reductase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50244"
SQ SEQUENCE 280 AA; 32594 MW; 1A34066784340853 CRC64;
LRHSPVEILD AKTREKLCFL DKVELGQGKS LKDEDVLQKL PVGTTATLYF RDLGAQISWV
TVFLTEYAGP LFIYLLFYFR VPFIYGHKYD FTSSRHTVVH LACICHSFHY IKRLLETLFV
HRFSHGTMPL RNIFKNCTYY WGFAAWMAYY INHPLYTPPT YGAQQVKLAL AIFVICQLGN
FSIHMALRDL RPAGSKTRKI PYPTKNPFTW LFLLVSCPNY TYEVGSWIGF AIMTQCLPVA
LFSLVGFTQM TIWAKGKHRS YLKEFRDYPP LRMPIIPFLL
//
