ID A0A2R9ANM0_PANPA Unreviewed; 585 AA.
AC A0A2R9ANM0;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Acyl-CoA thioesterase 11 {ECO:0000313|Ensembl:ENSPPAP00000018951.1};
GN Name=ACOT11 {ECO:0000313|Ensembl:ENSPPAP00000018951.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000018951.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000018951.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000018951.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=butanoyl-CoA + H2O = butanoate + CoA + H(+);
CC Xref=Rhea:RHEA:40111, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17968, ChEBI:CHEBI:57287, ChEBI:CHEBI:57371;
CC Evidence={ECO:0000256|ARBA:ARBA00000295};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40112;
CC Evidence={ECO:0000256|ARBA:ARBA00000295};
CC -!- PATHWAY: Lipid metabolism; fatty acid metabolism.
CC {ECO:0000256|ARBA:ARBA00004872}.
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DR EMBL; AJFE02049426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02049427; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02049428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02049429; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02049430; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02049431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02049432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9ANM0; -.
DR Ensembl; ENSPPAT00000041699.1; ENSPPAP00000018951.1; ENSPPAG00000032622.1.
DR GeneTree; ENSGT00940000156460; -.
DR UniPathway; UPA00199; -.
DR Proteomes; UP000240080; Chromosome 1.
DR Bgee; ENSPPAG00000032622; Expressed in adult mammalian kidney and 5 other cell types or tissues.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0016790; F:thiolester hydrolase activity; IEA:InterPro.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd03442; BFIT_BACH; 2.
DR CDD; cd08913; START_STARD14-like; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 2.
DR InterPro; IPR040170; Cytosol_ACT.
DR InterPro; IPR033120; HOTDOG_ACOT.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR InterPro; IPR006683; Thioestr_dom.
DR PANTHER; PTHR11049; ACYL COENZYME A THIOESTER HYDROLASE; 1.
DR PANTHER; PTHR11049:SF1; ACYL-COENZYME A THIOESTERASE 11; 1.
DR Pfam; PF03061; 4HBT; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 2.
DR PROSITE; PS51770; HOTDOG_ACOT; 2.
DR PROSITE; PS50848; START; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01106};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine esterase {ECO:0000256|ARBA:ARBA00022487}.
FT DOMAIN 42..144
FT /note="HotDog ACOT-type"
FT /evidence="ECO:0000259|PROSITE:PS51770"
FT DOMAIN 205..318
FT /note="HotDog ACOT-type"
FT /evidence="ECO:0000259|PROSITE:PS51770"
FT DOMAIN 390..565
FT /note="START"
FT /evidence="ECO:0000259|PROSITE:PS50848"
SQ SEQUENCE 585 AA; 66008 MW; B5F34909826C44DE CRC64;
ILRAVGSHQR GLASVFSNRT SRKSALRAGN DSAMADGEGY RNPTEVQMSQ LVLPCHTNQR
GELSIGQLLK WIDTTACLSG NAALPMVPYL PHSVGQVVNI KAKVNRAFNS SMEVGIQVAS
EDLCSEKQWN VCKALATFVA RREITKVKLK QITPRTEEEK MEHSVAAERR RMRLVYADTI
KDLLANCAIQ DDLESRDCSR MVPAEKTRVE SVELVLPPHA NHQGNTFGGQ IMAWMENVAT
IAASRLCRAH PTLKTIEMFH FRGPSQVGDR LVLKAIVNNA FKHSMEVGVC VEAYRQEAET
HRRHINSAFM TFVVLDADDQ PQLLPWIRPQ PGDGERRYRE ASARKKIRLD RKYIVSCKQT
EVPLSVPWDP SNQVCLSYNN VSSLKMLVAK DNWVLSSEIS QVRLYTLEDD KFLSFHMEMV
VHVDAAQAFL LLSDLRQRPE WDKHYRSVEL VQQVDEDDAI YHVTSPALGG HTKPQDFVIL
ASRRKPCDNG CVDPYVIALR SVTLPTHRET PEYRRGETLC SGFCLWREGD QLTKVSYYNQ
ATPGVLNYVT TNVAGLSSEF YTTFKACEQF LLDNRNDLAP SLQTL
//
