ID A0A2R9ANP6_PANPA Unreviewed; 1173 AA.
AC A0A2R9ANP6;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=NLR family pyrin domain containing 5 {ECO:0000313|Ensembl:ENSPPAP00000017310.1};
GN Name=NLRP5 {ECO:0000313|Ensembl:ENSPPAP00000017310.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000017310.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000017310.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000017310.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR EMBL; AJFE02030596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030597; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030600; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9ANP6; -.
DR Ensembl; ENSPPAT00000040012.1; ENSPPAP00000017310.1; ENSPPAG00000031725.1.
DR GeneTree; ENSGT00940000162898; -.
DR OMA; HEHYKES; -.
DR Proteomes; UP000240080; Chromosome 19.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF7; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 5; 1.
DR Pfam; PF13516; LRR_6; 6.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM00368; LRR_RI; 11.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 2.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT DOMAIN 69..148
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 257..387
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 142..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1173 AA; 131650 MW; A956D9154B460E1C CRC64;
MKVAGGLELG AVNLLQDPLL SLVTLSTGPT CSILPKNPLF PQNLSSQPCI KMEGDKSLTF
SSYGLQWCLY ELDKEEFQTF KELLKKKSSE STTCSIPQFE IENANVECLA LLLHEYYGAS
LAWATSISIF ENMNLRTLSE KARDDMKRHS PEDPEATTTD QGPSKEKVPG YNKHKYVGIH
SSFAEISQAM EQEGATAAET EEQGHGGDTW DYKSHVMTKF AEEQDVRRSF EKTAADWPEM
QTLAGAFNSD QWGFRPRTVV LHGKSGIGKS ALARRIVLCW AQGGLYQGMF SYVFFLPVRE
MQRKKESSVT EFISREWPDS QAPVTEIMSR PERLLFIIDG FDDLGSVLSS DTKLCKDWAE
KQPPFILIRS LLRKVLLPES FLIITVRDVG IEKLKSEVVS PRYLLVRGIS GEQRIHLLLE
RGIGEHQKTQ GLRAIMNNRK LFDQCQVPAV GSLICVALQL QDVVGESVAP FNQTLTGLYA
AFVFHQLTPR GVARRCLNLE ERVVLKRFCR MAVEGVWNRK SVFDGDDLMV QGLGESELRA
LFHMNILLPD SHCEEHYTFF HLSLQDFCAA LYYVLEGLEI EPALCPLYVE KTKRSMELKQ
AGFHIHSLWM KRFLFGLVSE DVRRPLEVLL GCPVPLGVKQ KLLHWVSLLG QQQKAPGDTL
DAFHCLFETQ DKEFVRLALN GFQEVWLPIN QNLDLIASSF CLQHCPYLRK IRVDVKGIFP
RDESTEACPV VPLWMRGKTL IEEQWEDFCS VLGTHPHLRQ LDLGSSILTE RAMKTLCAKL
RHSTCKIQTL MFRNAQITPG VQHLWRILMA NRNLRSLNLG GTHLKEEDVR MACEALKHPK
CLLESLRLDC CGLTHACYLK ISQILTTSPS LKSLSLAGNK VTDQGVTPLS DALRVSQCAL
QKLILEDCGI TATGCQSLAS ALVSNRSLTH LCLSNNSLGN EGVNLLCRSM RLPHCSLQRL
NQCHLDTAGC GFLALALMGN SWLTHLSLSM NPVEDNGVKL LCEVMREPSC HLQDLELVKC
HLTAACCESL SCVISRSRHL KSLDLTDNAL GDGGVAALCE GLKQKNSVLT RLGLKACGLT
SDCCEALSLA LSCNRHLTSL NLVQNNFSPK GMMKLCSAFA CPTSNLQIIG LWKWQYPVQI
RKLLEEVQLL KPQIVIDGSW HSFDEDDRYW WKN
//
