ID A0A2R9ANV3_PANPA Unreviewed; 853 AA.
AC A0A2R9ANV3;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Dynamin-binding protein {ECO:0000256|ARBA:ARBA00018186};
DE AltName: Full=Scaffold protein Tuba {ECO:0000256|ARBA:ARBA00032587};
GN Name=DNMBP {ECO:0000313|Ensembl:ENSPPAP00000016644.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000016644.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000016644.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000016644.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Golgi apparatus, Golgi stack
CC {ECO:0000256|ARBA:ARBA00004348}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
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DR EMBL; AJFE02089623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02089624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02089625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02089626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02089627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02089628; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02089629; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02089630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02089631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02089632; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9ANV3; -.
DR Ensembl; ENSPPAT00000039342.1; ENSPPAP00000016644.1; ENSPPAG00000031406.1.
DR GeneTree; ENSGT00950000183088; -.
DR OMA; REGEKWY; -.
DR Proteomes; UP000240080; Chromosome 10.
DR Bgee; ENSPPAG00000031406; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005795; C:Golgi stack; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07589; BAR_DNMBP; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11798; SH3_DNMBP_C1; 1.
DR CDD; cd12141; SH3_DNMBP_C2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR035820; DNMBP_SH3_C1.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR22834:SF19; DYNAMIN-BINDING PROTEIN; 1.
DR PANTHER; PTHR22834; NUCLEAR FUSION PROTEIN FUS2; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR01887; SPECTRNALPHA.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 66..243
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 284..493
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 561..624
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 789..852
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 624..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..681
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 853 AA; 96521 MW; DB06548C4697D537 CRC64;
MPTLFKGHSR ALGRFCPACL PSGPHLHTQP TLGTAEMTLL SSQSSSLVAP SGSVSAENPE
QRMLEKRAKV IEELLQTERD YIRDLEMCIE RIMVPMQQAQ VPNIDFEGLF GNMQMVIKVS
KQLLAALEIS DAVGPVFLGH RDELEGTYKI YCQNHDEAIA LLEIYEKDEK IQKHLQDSLA
DLKGCTNYIN LGSFLIKPVQ RVMRYPLLLM ELLNSTPESH PDKVPLTNAV LAVKEITVNI
NEYKRRKDLV LKYRKGDEDS LMEKISKLNI HSIIKKSNRV SSHLKHLTGF APQIKDEVFE
ETEKNFRMQE RLIKSFIRDL SLYLQHIRES ACVKVVAAVS MWDVCMERGH WDLEQFERVH
RYISDQLFTN FKERTERLVI SPLNQLLSMF TGPHKLVQKR FDKLLDFYNC TERAEKLKDK
KTLEELQSAR NNYEALNAQL LDELPKFHQY AQGLFTNCVH GYAEAHCDFV HQALEQLKPL
LSLLKVAGRE GNLIAIFHEE HSRVLQQLQV FTFFPESLPA TKKPFERKTI DRQSARKPLL
GLPSYMLQSE ELRASLLARY PPEKLFQAER NFNAAQDLDV SLLEGDLVGV IKKKDPMGSQ
NRWLIDNGVT KGFVYSSFLK PYNPRRSHSD ASVGSHSSTE SEHGSSSPRF PRQNSGSTLT
FNPSSMAVSF TSGSCQKQPQ DASPPPKECD QGTLSASLNP SNSESSPSRC PSDPDSTSQP
RSGDSADVAR DVNQPTATPR SYRNFRHPEI VGYSVPGRNG QSQDLVKGCA RTAQAPEDRS
TEPDGSEAEG NQVYFAVYTF KARNPNELSV SANQKLKILE FKDVTGNTEW WLAEVNGKKG
YVPSNYIRKT EYT
//
