ID A0A2R9AQV3_PANPA Unreviewed; 560 AA.
AC A0A2R9AQV3;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=RasGEF domain family member 1B {ECO:0000313|Ensembl:ENSPPAP00000019543.1};
GN Name=RASGEF1B {ECO:0000313|Ensembl:ENSPPAP00000019543.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000019543.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000019543.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000019543.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AJFE02115023; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02115024; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02115025; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02115026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02115027; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02115028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02115029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02115030; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02115031; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02115032; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008955897.1; XM_008957649.1.
DR AlphaFoldDB; A0A2R9AQV3; -.
DR Ensembl; ENSPPAT00000042311.1; ENSPPAP00000019543.1; ENSPPAG00000032967.1.
DR GeneID; 100976234; -.
DR CTD; 153020; -.
DR GeneTree; ENSGT00940000155816; -.
DR OrthoDB; 7992at2759; -.
DR Proteomes; UP000240080; Chromosome 4.
DR Bgee; ENSPPAG00000032967; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF197; RAS-GEF DOMAIN-CONTAINING FAMILY MEMBER 1B; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT DOMAIN 121..248
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 292..540
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 560 AA; 64913 MW; 767C781195C3CF76 CRC64;
MAKFLAELLG CTLPSKGASP MFESKSHSRV GLKSSTKQKT TIFSTLASEK SLSDCKKEQQ
WKPSMYSSIT PVCFPSPLIE KPIDKESMPQ TPPFSAMFDS SGYNRNLYQS AEDSCGGLYY
HDNNLLSGSL EALIQHLVPN VDYYPDRTYI FTFLLSSRLF MHPYELMAKV CHLCVEHQRL
SDPDSDKNQM RKIAPKILQL LTEWTETFPY DFRDERMMRN LKDLAHRIAS GEEQTYRKNV
QQMMQCLIRK LAALSQYEEV LAKISSTSTD RLTVLKTKPQ SIQRDIITVC NDPYTLAQQL
THIELERLNY IGPEEFVQAF VQKDPLDNDK SCYSERKKTR NLEAYVEWFN RLSYLVATEI
CMPVKKKHRA RMIEYFIDVA RECFNIGNFN SLMAIISGMN MSPVSRLKKT WAKVKTAKFD
ILEHQMDPSS NFYNYRTALR GAAQRSLTAH SSREKIVIPF FSLLIKDIYF LNEGCANRLP
NGHVNFEKFW ELAKQVSEFM TWKQVECPFE RDRKILQYLL TVPVFSEDAL YLASYESEGP
ENHIEKDRWK SLRSSLLGRV
//
