ID A0A2R9ARN5_PANPA Unreviewed; 584 AA.
AC A0A2R9ARN5;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=EWS RNA binding protein 1 {ECO:0000313|Ensembl:ENSPPAP00000019838.1};
GN Name=EWSR1 {ECO:0000313|Ensembl:ENSPPAP00000019838.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000019838.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000019838.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000019838.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RRM TET family.
CC {ECO:0000256|ARBA:ARBA00008448}.
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DR EMBL; AJFE02038004; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02038005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02038006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02038007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02038008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02038009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02038010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9ARN5; -.
DR Ensembl; ENSPPAT00000042615.1; ENSPPAP00000019838.1; ENSPPAG00000032867.1.
DR GeneTree; ENSGT00940000154191; -.
DR Proteomes; UP000240080; Chromosome 22.
DR Bgee; ENSPPAG00000032867; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd12533; RRM_EWS; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 4.10.1060.10; Zinc finger, RanBP2-type; 1.
DR InterPro; IPR034869; EWS_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR034870; TET_fam.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR PANTHER; PTHR23238; RNA BINDING PROTEIN; 1.
DR PANTHER; PTHR23238:SF3; RNA-BINDING PROTEIN EWS; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF00641; zf-RanBP; 1.
DR SMART; SM00360; RRM; 1.
DR SMART; SM00547; ZnF_RBZ; 1.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
DR PROSITE; PS50199; ZF_RANBP2_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00322}.
FT DOMAIN 289..375
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 446..477
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT REGION 124..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 471..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..195
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..404
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..490
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..584
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 584 AA; 61433 MW; 9681285AD78A5BE8 CRC64;
MASTDYSTYS QAAAQQGYSA YTAQPTQGYA QTTQQAYGQQ SYGTYGQPTD VSYTQAQTTA
TYGQTAYATS YGQPPTGYTT PTAPQAYSQP VQGYGTGAYD TTTATVTTTQ ASYAAQSAYG
TQPAYPAYGQ QPAATAPTRP QDGNKPTETS QPQSSTGGYN QPSLGYGQSN YSYPQVPGSY
PMQPVTAPPS YPPTSYSSTQ PTSYDQSSYS QQNTYGQPSS YGQQSSYGQQ SSYGQQPPTS
YPPQTGSYSQ APSQYSQQSS SYGQQRPMDE GPDLDLGPPV DPDEDSDNSA IYVQGLNDSV
TLDDLADFFK QCGVVKMNKR TGQPMIHIYL DKETGKPKGD ATVSYEDPPT AKAAVEWFDG
KDFQGSKLKV SLARKKPPMN SMRGGMPPRE GRGMPPPLRG GPGGPGGPGG PMGRMGGRGG
DRGGFPPRGP RGSRGNPSGG GNVQHRAGDW QCPNPGCGNQ NFAWRTECNQ CKAPKPEGFL
PPPFPPPGGD RGRGGPGGMR GGRGGLMDRG GPGGMFRGGR GGDRGGFRGG RGMDRGGFGG
GRRGGPGGPP GPLMEQMGGR RGGRGGPGKM DKGEHRQERR DRPY
//
