ID A0A2R9ARZ3_PANPA Unreviewed; 165 AA.
AC A0A2R9ARZ3;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Baculoviral IAP repeat-containing protein 5 {ECO:0000256|ARBA:ARBA00039922};
DE AltName: Full=Apoptosis inhibitor survivin {ECO:0000256|ARBA:ARBA00042407};
GN Name=BIRC5 {ECO:0000313|Ensembl:ENSPPAP00000018535.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000018535.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000018535.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000018535.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}. Midbody
CC {ECO:0000256|ARBA:ARBA00004214}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the IAP family. {ECO:0000256|ARBA:ARBA00006672}.
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DR EMBL; AJFE02062458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02062459; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02062460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9ARZ3; -.
DR STRING; 9597.ENSPPAP00000018535; -.
DR Ensembl; ENSPPAT00000041267.1; ENSPPAP00000018535.1; ENSPPAG00000032377.1.
DR GeneTree; ENSGT00510000047537; -.
DR OMA; IKMYFYE; -.
DR Proteomes; UP000240080; Chromosome 17.
DR Bgee; ENSPPAG00000032377; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0007127; P:meiosis I; IEA:Ensembl.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0061178; P:regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0061469; P:regulation of type B pancreatic cell proliferation; IEA:Ensembl.
DR CDD; cd00022; BIR; 1.
DR InterPro; IPR001370; BIR_rpt.
DR PANTHER; PTHR46771:SF3; BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 5; 1.
DR PANTHER; PTHR46771; DETERIN; 1.
DR Pfam; PF00653; BIR; 1.
DR SMART; SM00238; BIR; 1.
DR SUPFAM; SSF57924; Inhibitor of apoptosis (IAP) repeat; 1.
DR PROSITE; PS50143; BIR_REPEAT_2; 1.
PE 3: Inferred from homology;
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Thiol protease inhibitor {ECO:0000256|ARBA:ARBA00022704}.
FT COILED 129..164
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 165 AA; 18527 MW; 85F824A012E8CC69 CRC64;
MGAPTLPPAW QPFLKDHRIS TFKNWPFLEG CACTPERMAE AGFIHCPTEN EPDLAQCFFC
FKELEGWEPD DDPIGPGAVA HACNTSTLGG RGGRITREEH KKHSSGCAFL SVKKQFEELT
LGEFLKLDRE RAKNKIAKET NNKKKEFEET AKKVRCAIEQ LAAMD
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