ID A0A2R9ATN2_PANPA Unreviewed; 266 AA.
AC A0A2R9ATN2;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=DNA damage regulated autophagy modulator 2 {ECO:0000313|Ensembl:ENSPPAP00000020676.1};
GN Name=DRAM2 {ECO:0000313|Ensembl:ENSPPAP00000020676.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000020676.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000020676.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000020676.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the DRAM/TMEM150 family.
CC {ECO:0000256|ARBA:ARBA00006565}.
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DR EMBL; AJFE02033032; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02033033; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003810723.1; XM_003810675.3.
DR RefSeq; XP_008961249.1; XM_008963001.2.
DR RefSeq; XP_008961250.1; XM_008963002.2.
DR AlphaFoldDB; A0A2R9ATN2; -.
DR STRING; 9597.ENSPPAP00000020676; -.
DR Ensembl; ENSPPAT00000043472.1; ENSPPAP00000020676.1; ENSPPAG00000033552.1.
DR GeneID; 100976405; -.
DR KEGG; pps:100976405; -.
DR CTD; 128338; -.
DR GeneTree; ENSGT01030000234578; -.
DR OMA; CVYIRHR; -.
DR OrthoDB; 2896974at2759; -.
DR Proteomes; UP000240080; Chromosome 1.
DR Bgee; ENSPPAG00000033552; Expressed in placenta and 6 other cell types or tissues.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:0001917; C:photoreceptor inner segment; IEA:Ensembl.
DR GO; GO:0045494; P:photoreceptor cell maintenance; IEA:Ensembl.
DR GO; GO:0010506; P:regulation of autophagy; IEA:Ensembl.
DR GO; GO:0007601; P:visual perception; IEA:Ensembl.
DR InterPro; IPR019402; Frag1/DRAM/Sfk1.
DR PANTHER; PTHR21324:SF10; DNA DAMAGE-REGULATED AUTOPHAGY MODULATOR PROTEIN 2; 1.
DR PANTHER; PTHR21324; FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED; 1.
DR Pfam; PF10277; Frag1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 55..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 94..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 266 AA; 29766 MW; 4F91D5C212D458E5 CRC64;
MWWFQQGLSF LPSALVIWTS AAFIFSYITA VTLHHIDPAL PYISDTGTVA PEKCLFGAML
NIAAVLCIAT IYVRYKQVHA LSPEENVIIK LNKAGLVLGI LSCLGLSIVA NFQKTTLFAA
HVSGAVLTFG MGSLYMFVQT ILSYQMQPKI HGKQVFWIRL LLVIWCGVSA LSMLTCSSVL
HSGNFGTDLE QKLHWNPEDK GYVLHMITTA AEWSMSFSFF GFFLTYIRDF QKISLRVEAN
LHGLTLYDTA PCPINNERTR LLSRDI
//
