ID A0A2R9ATW6_PANPA Unreviewed; 932 AA.
AC A0A2R9ATW6;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
GN Name=GRIK1 {ECO:0000313|Ensembl:ENSPPAP00000018354.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000018354.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000018354.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000018354.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC channel in the central nervous system and plays an important role in
CC excitatory synaptic transmission. L-glutamate acts as an excitatory
CC neurotransmitter at many synapses in the central nervous system.
CC {ECO:0000256|RuleBase:RU367118}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC Postsynaptic cell membrane {ECO:0000256|RuleBase:RU367118}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|RuleBase:RU367118}.
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DR EMBL; AJFE02041974; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02041975; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02041976; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02041977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02041978; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02041979; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9ATW6; -.
DR STRING; 9597.ENSPPAP00000018354; -.
DR Ensembl; ENSPPAT00000041084.1; ENSPPAP00000018354.1; ENSPPAG00000032151.1.
DR GeneTree; ENSGT00940000156253; -.
DR Proteomes; UP000240080; Chromosome 21.
DR Bgee; ENSPPAG00000032151; Expressed in prefrontal cortex and 3 other cell types or tissues.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0007215; P:glutamate receptor signaling pathway; IEA:UniProt.
DR CDD; cd06382; PBP1_iGluR_Kainate; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF36; GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367118};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU367118};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU367118};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|RuleBase:RU367118};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367118};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367118};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118}.
FT TRANSMEM 561..580
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 637..659
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 818..842
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT DOMAIN 431..799
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 441..505
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 932 AA; 106113 MW; E5C9A58BEF788B0E CRC64;
LHVAHPGIWD LLYYSIYHLG SLIWIFETVE NEPVNVEELA FKFAVTSINR NRTLMPNTTL
TYDIQRINLF DSFEASRRAC DQLALGVAAL FGPSHSSSVS AVQSICNALE VPHIQTRWKH
PSVDNKDLFY INLYPDYAAI SRAILDLVLY YNWKTVTVVY EDSTGLIRLQ ELIKAPSRYN
IKIKIRQLPS GNKDAKPLLK EMKKGKEFYV IFDCSHETAA EILKQILFMG MMTEYYHYFF
TTLDLFALDL ELYRYSGVNM TGFRLLNIDN PHVSSIIEKW SMERLQAPPR PETGLLDGMM
TTEAALMYDA VYMVAIASHR ASQLTVSSLQ CHRHKPWRLG PRFMNLIKEA RWDGLTGHIT
FNKTNGLRKD FDLDIISLKE EGTEKAAGEV SKHLYKVWKK IGIWNSNSGL NMTDSNKDKS
SNITDSLANR TLIVTTILEE PYVMYRKSDK PLYGNDRFEG YCLDLLKELS NILGFIYDVK
LVPDGKYGAQ NDKGEWNGMV KELIDHRADL AVAPLTITYV REKVIDFSKP FMTLGISILY
RKPNGTNPGV FSFLNPLSPD IWMYVLLACL GVSCVLFVIA RFTPYEWYNP HPCNPDSDVV
ENNFTLLNSF WFGVGALMQQ GSELMPKALS TRIVGGIWWF FTLIIISSYT ANLAAFLTVE
RMESPIDSAD DLAKQTKIEY GAVRDGSTMT FFKKSKISTY EKMWAFMSSR QQTALVRNSD
EGIQRVLTTD YALLMESTSI EYVTQRNCNL TQIGGLIDSK GYGVGTPIGS PYRDKITIAI
LQLQEEGKLH MMKEKWWRGN GCPEEDNKEA SALGVENIGG IFIVLAAGLV LSVFVAIGEF
IYKSRKNNDI EQKGKSSRIR FYFRNKVRFH GRKKQSLGVE KCLSFNAIME ELGISLKNQK
KIKKKSRTKG KSSFTSILTC HQRRTQRKET VA
//