ID A0A2R9AU79_PANPA Unreviewed; 745 AA.
AC A0A2R9AU79;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Adhesion G protein-coupled receptor E1 {ECO:0000313|Ensembl:ENSPPAP00000020866.1};
GN Name=ADGRE1 {ECO:0000313|Ensembl:ENSPPAP00000020866.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000020866.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000020866.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000020866.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJFE02066336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02066337; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02066338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02066339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02066340; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02066341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02066342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003819402.1; XM_003819354.1.
DR AlphaFoldDB; A0A2R9AU79; -.
DR Ensembl; ENSPPAT00000043663.1; ENSPPAP00000020866.1; ENSPPAG00000033638.1.
DR GeneTree; ENSGT00940000161354; -.
DR OrthoDB; 1114672at2759; -.
DR Proteomes; UP000240080; Chromosome 19.
DR Bgee; ENSPPAG00000033638; Expressed in liver and 3 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15439; 7tmB2_EMR; 1.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR001740; GPCR_2_EMR1-like_rcpt.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR12011:SF449; ADHESION G PROTEIN-COUPLED RECEPTOR E1; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR01128; EMR1HORMONER.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023040};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..745
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015321109"
FT TRANSMEM 459..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 496..515
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 527..551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 572..590
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 610..635
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 655..677
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 683..706
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..68
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 80..115
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 127..164
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 461..707
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 721..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 84..94
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 745 AA; 82833 MW; 480659D5B1B3D1F5 CRC64;
MRGFNLLLFW GCCVMHSWER HIRPTRKPNT KGNNCRDSTL CPAYATCTNT VDSYYCTCKR
GFLSSNGQNH FKGPGVQCKD IDECTEMCPI NSTCTNTPGS YFCTCHPGFA PSNGHLNFTD
QEVECRDIDE CHQDPSTCGP NSICTNALGS YSCGCIAGFH PNPEGSQKDS NFSCQRVLFK
CKEDMIPDKK QIQQCQEGTA VKPAYVSFCA QINNIFSVLD KVCENKTTVV SLKNTTESFV
PVLKQISTWT KFTKEETSSL ATVFLESVES MTLASFWKPS ANVTPAVRTE YLDIESKVIN
KECSEENVTL NLVAKGDKMK IGCSTIEESE STETTGVAFV SFVGMESVLN ERFFQDHQAP
LTTSEIKLKM NSRVVGGIMT GEKKDGFSDP VIYTLENIQP KQKFERPICV SWSTDVKGGR
WTSFGCVILE ASETYTVCSC NQMANLAVIM ASGELTMDFS LYIISHVGII ISLVCLVLAI
ATFLLCRSIR NHNTYLHLHL CVCLLSAKTL FLAGIHKTDN KTGCAIIAGF LHYLFLACFF
WMLVEAVILF LMVRNLKVVN YFSSRNIKML HICAVGYGLP MLVVVISASV QPQGYGMHNR
CWLNTETGFI WSFLGPVCTV IVINSLLLTW TLWILRQRLS SVNAEVSTLK DTRLLTFKAF
AQLFILGCSW VLGIFQIGPV AGVMAYLFTI INSLQGAFIF LIHCLLNGQV REEYKRWITG
KTKPSSQSQT SRILLSSMPS ASKTG
//
